Valerie Sandra LeBleu
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Valerie Sandra LeBleu
Education
- BS from Florida Institute of Technology
- 12/2003 - Melbourne, Florida United States
- PhD from Harvard University
- 06/2009 - Boston, Massachusetts United States
- MD from Northwestern Feinberg School of Medicine
- 05/2023 - Chicago, Illinois United States
- MBA from Northwestern Kellogg School of Management
- 05/2023 - Chicago, Illinois United States
Honors & Awards
- James P. and Christine M. Kelly Family Medical Scholarship
- Feinberg School of Medicine, Northwestern University (06/2022)
- National Kidney Foundation of Illinois
- Medical Student Research Grant Award (06/2019)
- Wilson S. Stone Award
- The University of Texas MD Anderson Cancer Center (06/2015)
- Rising STARS Science and Technology Acquisition and Retention
- The University of Texas MD Anderson Cancer Center (06/2014)
- Young Ambassador Award
- Metastasis Research Society (06/2012)
Selected Publications
- Mahadevan KK, LeBleu VS , Ramirez EV [...] DePinho RA, Anirban Maitra A, McAndrews KM, Raghu Kalluri R "Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells." Dev Cell. 2023 Aug 24;58(17):1562-1577. Pubmed PMID: 37625403
- Haltom AR [...] LeBleu VS, Kalluri R "Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma." Extracell Vesicle. 2022 Oct 27;1(100014) Pubmed PMID: 37503329
- McAndrews KM, [...] LeBleu VS, Kalluri R "Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer." Cancer Discov. 2022 Jun 2;12(6):1580-1597.. Pubmed PMID: 35348629
- LeBleu VS [...] Tainer J, Zon LI, Kallur R "Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish." Dev Dyn. 2023 Apr 17;252(7):1046-1060. Pubmed PMID: 37002899
- Mahadeva KK, McAndrews KM, LeBleu VS, [...], Maitra A, Heffernan TP, Kalluri R "KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells." Cancer Cell. 2023 Aug 24;41(9):1606-1620. Pubmed PMID: 37625401
- LeBleu VS "Plasticity Enables Cooperation among Heterogeneous Cancer Cell Populations to Support Metastatic Fitness." Cancer Res. 2022 May 22;82(10):1870-1871. Pubmed PMID: 35570704
- LeBleu VS & Thiery JP "The Continuing Search for Causality between Epithelial-to-Mesenchymal Transition and the Metastatic Fitness of Carcinoma Cells." Cancer Res. 2022 Apr 15;82(8):1467-1469. Pubmed PMID: 35425957
- El-Shennawy L, [...] Lebleu VS, [...] Liu H "Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2." Nat Commun. 2022 Jan 20;13(1):405. Pubmed PMID: 35058437
- McAndrews KM, [...] LeBleu VS, Ge Y, Kalluri R "Dermal αSMA+ myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production." EMBO J. 2022 Feb 25;41(7):e109470. Pubmed PMID: 35212000
- Zhou X, [...] LeBleu VS, [...] Kalluri R "Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer." Mol Ther Methods Clin Dev. 2021 May 29;22:360-376. Pubmed PMID: 34514028
- McAndrews KM, [...] LeBleu VS, Kalluri R "αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression." Oncogene. 2021 Jun 9;40(26):4440-4452. Pubmed PMID: 34108617
- McAndrews KM, [...] LeBleu VS, Kugeratski FG, Kalluri R "Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer." Life Sci Alliance. 2021 Jul 19;4(9):e202000875. Pubmed PMID: 34282051
- Hensel J, [...] LeBleu VS, Kalluri R "Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses." Sci Rep. 2020 Oct 27;10(1):18377. Pubmed PMID: 33110184
- Tang M, [...] LeBleu VS, McAndrews KM, Kalluri R "Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis." FASEB. 2021 May;35(5):e21557. Pubmed PMID: 33855751
- Chen Y, [...] LeBleu VS, Kalluri R "Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer." Cancer Cell. 2021 Apr 12;39(4):548-565. Pubmed PMID: 33667385
- McAndrews KM, Che SPY, LeBleu VS, Kalluri R "Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity." J Biol Chem. 2021 Jan;296:100523. Pubmed PMID: 33711340
Languages
French
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