Shixia Huang, Ph.D.
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Shixia Huang, Ph.D.
Professor
Positions
- Professor
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Mol & Cell Biology
Baylor College of Medicine
- Director, Antibody-Based Proteomics Core
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Advanced Technology Cores
Baylor College of Medicine
Houston, Texas United States
- Professor
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Education, Innovation & Technology
Baylor College of Medicine
- Faculty Senator
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Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
- Program Director, BRITE
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Baylor College of Medicine
Biotechnology Research Incubator for Teachers and Students (BRITE) www.bcm.edu/BRITE
Education
- PhD from Michigan State University
- East Lansing, Michigan United States
- Genetics
- Postdoctoral Fellowship at National Cancer Institute
- Bethesda, Maryland United States
- Postdoctoral Fellowship at Memorial Sloan-Kettering Cancer Center
- New York, New York United States
- MS from Yangzhou University
- Yangzhou, Jiangsu China, People's Rep
- Infectious Disease & Preventive Veterinary Medicine
- BS from Hunan Agricultural University
- Changsha, Hunan China, People's Rep
- Veterinary Medicine
Professional Statement
Developing high-throughput antibody-based proteomic platforms for protein biomarker discovery and validation, especially for low abundance regulatory proteins and their activation states such as phosphorylation and histone translational modifications.Combining my advanced technology expertise and passion for education to build biotechnology research education programs.
Websites
The Antibody-based Proteomics Core provides cutting-edge antibody-based proteomic platforms for both validation and protein biomarker discovery, particularly for low abundance regulatory proteins and activation states of proteins with phosphorylated antibodies.
Leveraging Baylor College of Medicine's advanced technology and cancer research resources, the Biotechnology Research Education Programs include NIH-funded training programs for teachers and college students, as well as internally funded programs for high school students by the Lester and Sue Smith Center.
Selected Publications
- Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE, Varmus HE "Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice.." Genome Biol.. 2005;6(10):R84. Pubmed PMID: 16207355
- Huang S, Flanders KC, Roberts AB "Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues.." Gene. 2000 Nov 27;258(41276):43-53. Pubmed PMID: 11111041
- Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE "Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.." Proc. Natl. Acad. Sci. U.S.A.. 2003 Dec 23;100(26):15853-8. Pubmed PMID: 14668450
- Lu, H.-Y., Xiong, j., Perera, D. N., Rajapakshe, K., Wang, X., Costello M., Holloway K. R., Ramos, C., Grimm, S. L., Wulfkuhle, J., Coarfa, C., Edwards, D. P., Zhu, M. X., and Huang, S. "High-throughput Evaluation of Metabolic Activities Using Reverse Phase Protein Array (RPPA) Technology." Book chapter in: Tong, Q., 1st ed. Neuronal Signaling in Metabolism. 2021 Jun;1st Edition:25.
- Coarfa C, Grimm SL, Rajapakshe K, Perera D, Lu HY, Wang X, Christensen KR, Mo Q, Edwards DP, Huang S. "Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration." J Biomol Tech.. 2021 Apr;32(1):15-29. Pubmed PMID: 34025221
- Dong J, Huang S, Caikovski M, Ji S, McGrath A, Custorio MG, Creighton CJ, Maliakkal P, Bogoslovskaia E, Du Z, Zhang X, Lewis MT, Sablitzky F, Brisken C, Li Y "ID4 regulates mammary gland development by suppressing p38MAPK activity.." Development. 2011 Dec;138(23):5247-56. Pubmed PMID: 22069192
- Huang S, Chen Y, Podsypanina K, Li Y "Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice.." Neoplasia. 2008 Feb;10(2):118-24. Pubmed PMID: 18283333
- Huang S, Tang B, Usoskin D, Lechleider RJ, Jamin SP, Li C, Anzano MA, Ebendal T, Deng C, Roberts AB "Conditional knockout of the Smad1 gene.." Genesis. 2002 Feb;32(2):76-9. Pubmed PMID: 11857782
Memberships
- Human Proteome Organization
- Education and Training Committee (03/2023)
- Association of Biomolecular Resource Facilities (ABRF)
- Education Committee (03/2021)
Funding
- Biotechnology Research Incubator for Teachers (BRITE)
- $1,250,000.00 ( 07/01/2024 - 04/30/2029 ) NIH R25 Science Educatin Partnership Award (SEPA)
- The Biotechnology Research Incubator for Teachers (BRITE) program provides middle school teachers in the Houston area with summer research opportunities, aligning with Next Generation Science Standards and bridging the gap between research experiences, AI guided literature adaptation,, and classroom instruction. BRITE aims to enhance science education, empower teachers, and inspire students to pursue STEMM fields.
- Cancer Research Education Program (C-REP) for NIH P20 BCM/TSU CURED
- ( 09/21/2023 - 08/31/2027 ) NIH P20 C-REP
- The Collaborative Cancer Research Education Program (C-REP) of the Baylor College of Medicine (BCM)/ Dan L Duncan Comprehensive Cancer Center (DLDCCC) and Texas Southern University (TSU) P20 Collaborative Union for Cancer Research, Education and Disparities (CURED) project will train 20 TSU underrepresented minority students in cancer research, cutting edge technologies, and career pathway. The cohort of 20 CURED scholars will participate in an 8-week mentored cancer research experience that integrates BCM and TSU infrastructures every summer followed by year-long culturally congruent outreach education activities that will increase the awareness, knowledge, and understanding of research, concepts, processes, and careers in cancer research/cancer health disparities.
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