Na Li, Ph.D.
Na Li, Ph.D.
- Associate Professor
Baylor College of Medicine
- Advanced Training from Baylor College Of Medicine
- 01/2012 - Houston, TX United States
- PhD from China Pharmaceutical University
- 07/2008 - Nanjing, China, People's Rep
- To investigate novel molecular mechanisms underlying cardiac arrhythmias and cardiomyopathy.
Professional StatementCardiac arrhythmias severely affect cardiac performance, and in some cases are lethal. Arrhythmias can result from dysfunctional ion channels located on the plasma membrane or abnormal intracellular calcium handling. We are interested in the following research topics:
One, inflammatory signaling in the pathogenesis of atrial fibrillation (AF).
AF is the most common cardiac arrhythmia in adults with an increasing prevalence. Several projects are designed to investigate the mechanistic link between the risk factors and the AF pathophysiology. Among them, inflammasome signaling is a central focus.
Second, molecular mechanisms of cardiac conduction disorder (CCD).
CCD is very common in patients with heart failure/cardiomyopathy or with a genetic cause. Patients with severe CCD usually require pacemaker implantation. Understanding the molecular underpinning of various forms of CCD may help to develop new therapies for patients suffering from CCD.
Li lab is funded by research grants from the National Institutes of Health.
- "Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.." Circ Arrhythm Electrophysiol.. 2014;
- "Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation.." Int J Cardiol.. 2015;
- "Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.." Circulation. 2018;
- "NLRP3 Inflammasome Is a Key Driver of Obesity-Induced Atrial Arrhythmias." Cardiovasc Res. 2021; Pubmed PMID: 33523143
- "Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation." Circulation. 2020; Pubmed PMID: 32717176
- "Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology." Nat Rev Cardiol. 2023; Pubmed PMID: 36109633
- "Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis." Circ Res. 2023; Pubmed PMID: 37154033
- "Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications." Front Physiol.. 2018;
- "Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation." J Clin Invest. 2023; Pubmed PMID: 37581942
- The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis Grant funding from NIH/NHLBI
- Cardiac fibroblast inflammasome and atrial myopathy Grant funding from NIH/NHLBI
- Mechanisms underlying atrial fibrillation associated with chronic kidney disease Grant funding from NIH/NHLBI
- Arrhythmogenesis associated with the TANGO2-deficiency Grant funding from American Heart Association
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