Murugesan Palaniappan
Picture
Murugesan Palaniappan
Assistant Professor
Positions
- Assistant Professor
-
Pathology & Immunology
Center for Drug Discovery
Baylor College of Medicine
Houston, Texas United States
- Group Leader
-
DNA encoded chemical library screening
Center for Drug Discovery
Baylor College of Medicine
- Member
-
Dan L Duncan Comprehensive Cancer Center
Education
- PhD from University of Madras
- 11/2007 - Chennai, India
- Postdoctoral Training at University of Michigan
- 08/2011 - Ann Arbor, Michigan United States
Professional Interests
- Breast cancer
- DNA encoded chemical library screening
- Drug Discovery and Development
Websites
Selected Publications
- Palaniappan M*, Nguyen L, Grimm SL Xi Y, Xia Z, Li W, Coarfa C "The Genomic Landscape of Estrogen Receptor α Binding in Mouse Mammary Gland." PloS One. 2019 : Pubmed PMID: 31408468
- Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OM. "Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells.." PLoS One. 2018 March ; : Pubmed PMID: 29590203
- Li JY, Miklossy G, Modukuri RK, Bohren KM, Yu Z, Palaniappan M, Faver JC, Riehle K, Matzuk MM, Simmons N. "Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis.." Bioconjug Chem.. 2019 August ; : Pubmed PMID: 31329429
- Du HC, Simmons N, Faver JC, Yu Z, Palaniappan M, Riehle K, Matzuk MM. "A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4.." Org Lett. 2019 : Pubmed PMID: 30860855
- Palaniappan M, Menon KM. "Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway.." Mol Endocrinol. 2010 : Pubmed PMID: 20660299
- Palaniappan M, Menon KM "Luteinizing hormone/human chorionic gonadotropin--mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells.." Mol Endocrinol. 2012 July ; : Pubmed PMID: 22827930
- Will MA, Palaniappan M, Peegel H, Kayampilly P, Menon KM "Metformin: direct inhibition of rat ovarian theca-interstitial cell proliferation." Fertil Steril. 2012 July ; : Pubmed PMID: 22608319
- Palaniappan M, Menon KM. "Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells.." Biol Reprod. 2009 : Pubmed PMID: 19299314
- Muthusamy T, Murugesan P, Srinivasan C, Balasubramanian K. "Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat.." Mol Cell Biochem. 2011 June ; : Pubmed PMID: 21301931
- Palaniappan M, Menon B, Menon KM "Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway.." Mol Cell Endocrinol.. 2013 : Pubmed PMID: 23261705
- Taylor DM, Anglin J, Park S, Ucisik MN, Faver JC, Simmons N, Jin Z, Palaniappan M, Nyshadham P, Li F, Campbell J, Hu L, Sankaran B, Prasad BVV, Huang H, Matzuk MM, Palzkill T. "Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries." ACS Infect Dis.. 2020 May ; 6 : Pubmed PMID: 32182432
Memberships
- The Endocrine Society
- (03/2009 - 06/2013)
Funding
- Development of a Precision Drug to target Y537S Mutant Estrogen Receptor in Metastatic Breast Cancer - #R03CA259664
- $160,000.00 (12/13/2021 - 11/30/2023) Grant funding from NIH/NCI
- Development of Next-Generation Estrogen Receptor Mutant Inhibitors for Endocrine Resistant Metastatic Breast Cancer - #RP220524
- $769,179.00 (03/01/2022 - 02/28/2025) Grant funding from CPRIT
Skills
- SCIENTIST
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