Murugesan Palaniappan
Picture
Murugesan Palaniappan
Assistant Professor
Positions
- Assistant Professor
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Pathology & Immunology
Center for Drug Discovery
Baylor College of Medicine
Houston, Texas United States
- Group Leader
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DNA encoded chemical library screening
Center for Drug Discovery
Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Education
- PhD from University of Madras
- 11/2007 - Chennai, India
- Postdoctoral Training at University of Michigan
- 08/2011 - Ann Arbor, Michigan United States
Professional Interests
- Breast cancer
- DNA encoded chemical library screening
- Drug Discovery and Development
Websites
Selected Publications
- Palaniappan M and Bohren KM. "Purification and Biochemical Characterization of Mutant Ligand Binding Domain of Human Estrogen Receptor α protein." J Steroid Biochem Mol Biol.. 2025 Jul; Pubmed PMID: 40245990
- Palaniappan M "Current Therapeutic Opportunities for Estrogen Receptor Mutant Breast Cancer." Biomedicines. 2024 Dec;12(Estrogen for the Treatment and Prevention of Breast Cancer):1-17.
- Palaniappan M*, Nguyen L, Grimm SL Xi Y, Xia Z, Li W, Coarfa C "The Genomic Landscape of Estrogen Receptor α Binding in Mouse Mammary Gland." PloS One. 2019; Pubmed PMID: 31408468
- Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OM. "Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells.." PLoS One. 2018 Mar; Pubmed PMID: 29590203
- Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM. "Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening." J Med Chem. 2023; Pubmed PMID: 36719862
- Judge A, Sankaran B, Hu L, Palaniappan M, Birgy A, Prasad BVV, Palzkill T. "Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning." PNAS. 2024 Mar 19;121(12)::e2313513121. Pubmed PMID: 38483989
- Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Young DW, Teng M, Kim C, Matzuk MM. "Reversible male contraception by targeted inhibition of serine/threonine kinase 33." Science. 2024 May 23;384(6698):885-890. Pubmed PMID: 38781365
- Lu S, Hu L, Lin H, Judge A, Rivera P, Palaniappan M, Sankaran B, Wang J, Prasad BVV, Palzkill T. "An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes." Nat Commun. 2022; Pubmed PMID: 36344533
- Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, Wang J, Tan Z, Judge A, Hu L, Sankaran B, Li F, Prasad BVV, Matzuk MM, Palzkill T. "Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library." J Med Chem.. 2024 Jan 11;67(1):620-642.. Pubmed PMID: 38117688
- Li JY, Miklossy G, Modukuri RK, Bohren KM, Yu Z, Palaniappan M, Faver JC, Riehle K, Matzuk MM, Simmons N. "Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis.." Bioconjug Chem.. 2019 Aug; Pubmed PMID: 31329429
- Du HC, Simmons N, Faver JC, Yu Z, Palaniappan M, Riehle K, Matzuk MM. "A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4.." Org Lett. 2019; Pubmed PMID: 30860855
- Palaniappan M, Menon KM. "Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway.." Mol Endocrinol. 2010; Pubmed PMID: 20660299
- Palaniappan M, Menon KM "Luteinizing hormone/human chorionic gonadotropin--mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells.." Mol Endocrinol. 2012 Jul; Pubmed PMID: 22827930
- Will MA, Palaniappan M, Peegel H, Kayampilly P, Menon KM "Metformin: direct inhibition of rat ovarian theca-interstitial cell proliferation." Fertil Steril. 2012 Jul; Pubmed PMID: 22608319
- Palaniappan M, Menon KM. "Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells.." Biol Reprod. 2009; Pubmed PMID: 19299314
- Muthusamy T, Murugesan P, Srinivasan C, Balasubramanian K. "Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat.." Mol Cell Biochem. 2011 Jun; Pubmed PMID: 21301931
- Palaniappan M, Menon B, Menon KM "Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway.." Mol Cell Endocrinol.. 2013; Pubmed PMID: 23261705
- Taylor DM, Anglin J, Park S, Ucisik MN, Faver JC, Simmons N, Jin Z, Palaniappan M, Nyshadham P, Li F, Campbell J, Hu L, Sankaran B, Prasad BVV, Huang H, Matzuk MM, Palzkill T. "Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries." ACS Infect Dis.. 2020 May;6 Pubmed PMID: 32182432
- Ye Q, Belabed H, Wang Y, Yu Z, Palaniappan M, Li JY, Kalovidouris SA, MacKenzie KR, Teng M, Young DW, Fujihara Y, Matzuk MM. "Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections." Andrology. 2022; Pubmed PMID: 36209044
- Madasu C, Liao Z, Parks SE, Sharma KL, Bohren KM, Ye Q, Li F, Palaniappan M, Tan Z, Yuan F, Creighton CJ, Tang S, Masand RP, Guan X, Young DW, Monsivais D, Matzuk MM. "Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology." PNAS. 2024 May 8;121(19):e2322934121.
Memberships
- The Endocrine Society
- American Association for Cancer Research (AACR)
- Active Member
Funding
- Development of Next-Generation Estrogen Receptor Mutant Inhibitors for Endocrine Resistant Metastatic Breast Cancer - #RP220524
- $769,179.00 (03/01/2022 - 02/28/2025) Grant funding from CPRIT
- Development of a Precision Drug to target Y537S Mutant Estrogen Receptor in Metastatic Breast Cancer - #R03CA259664
- $160,000.00 (12/13/2021 - 11/30/2023) Grant funding from NIH/NCI
Skills
- SCIENTIST
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