Michael Francis Wangler, M.D.
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Positions
- Assistant Professor
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Molecular and Human Genetics
Baylor College of Medicine
Houston, TX US
- Faculty Member
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Graduate Programs in Development, Disease Models & Therapeutics and Genetics & Genomics
Baylor College of Medicine
Addresses
- Texas Children's Genetics Clinic (Clinic)
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Texas Children's Clinical Care Center
6701 Fannin St., 16th Floor
Houston, TX 77030
United States
Phone: (832) 822-4280
Texas Children's Genetics Clinic
- Duncan Neurological Research Institute (Lab)
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Room: DNRI-1050
Houston, TX 77030
United States
Phone: (832) 822-1240
michael.wangler@bcm.edu
Education
- MD from Baylor College Of Medicine
- Houston, TX United States
- Internship at Baylor College Of Medicine Affiliate Hospitals
- Houston, TX United States
- Pediatrics
- Residency at Baylor College Of Medicine Affiliate Hospitals
- Houston, TX
- Pediatrics
- Residency at Baylor College Of Medicine Affiliate Hospitals
- Houston, TX
- Clinical Genetics
Certifications
- American Board of Pediatrics
- American Board of Medical Genetics
Professional Interests
- Pediatric genetics
- Peroxisomal disorders
Professional Statement
Molecular and Developmental Mechanisms of Mendelian DisordersOur lab studies rare human disease phenotypes in order to gain insight into general principles of human health. Methods include clinical studies in rare disease, genomics and model organism genetics particularly Drosophila melanogaster. We are currently using Drosophila to study Mendelian disorders and their underlying genetic and developmental mechanisms in two major efforts:
1) Model Organisms and the Molecular Pathogenesis of Mendelian Disorders: We use Drosophila models for diagnostic paradigms. We are part of the Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN). We have also started a similar effort in underserved populations called Community TEXOME.
2) Mendelian Disorders of the Peroxisome and Organelle Dynamics: Peroxisomes are fundamental sub-cellular organelles present in all eukaryotic cells. We use clinical and Drosophila studies in the elucidation of mechanisms of Peroxisomal Biogenesis Disorders- Zellweger Spectrum disorders (PBD-ZSD). These diseases are expanding from autosomal recessive disorders to a broad range of human diseases related to peroxisomes.
Websites
Selected Publications
- Marcogliese PC, Deal SL, Andrews J, Harnish JM, (…) Wangler MF*, Yamamoto S* "Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases.." Cell Rep. 2022;38:110517. Pubmed PMID: 35294868
- Schulze KV, Hanchard NA, Wangler MF* "Biases in arginine codon usage correlate with genetic disease risk.." Genet Med. 2020;22:1407-1412. Pubmed PMID: 32371920
- Assia Batzir N, Kishor Bhagwat P, Larson A, Coban Akdemir Z, Bagłaj M, (…) Baylor-Hopkins Center for Mendelian Genomics, Posey JE, Lupski JR, Beaudet AL, Wangler MF* "Recurrent arginine substitutions in the ACTG2 gene are the primary driver of disease burden and severity in visceral myopathy.." Hum Mutat.. 2020;41:641-654. Pubmed PMID: 31769566
- Graves HK, Jangam S, Tan KL, Pignata A, Seto ES, Yamamoto S, Wangler MF* "A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease.." G3 (Bethesda). 2020;10:69-77. Pubmed PMID: 31767637
- Assia Batzir N, Bhagwat PK, Eble TN, Liu P, Eng CM, (…) Wangler MF* "De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.." Cold Spring Harb Mol Case Stud.. 2019;5:a003673. Pubmed PMID: 30850373
- Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, (…) Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA "Undiagnosed Diseases Network. Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.." N Engl J Med.. 2018;379:2131-2139. Pubmed PMID: 35913761
- Wangler MF*, Hubert L, Donti TR, Ventura MJ, Miller MJ, (…) Elsea SH "A metabolomic map of Zellweger spectrum disorders reveals novel disease biomarkers.." Genet Med.. 2018;20:1274-1283. Pubmed PMID: 29419819
- Wangler MF, Yamamoto S, Chao HT, Posey JE, Westerfield M, (…) Bellen HJ "Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research.." Genetics. 2017;207:9-27. Pubmed PMID: 28874452
- Luo X, Rosenfeld JA, Yamamoto S, Harel T, Pastore M, (...), Members of the UDN, Lotze T, Lupski JR, Lalani S, Yang Y, Lee B, Bellen HJ, Wangler MF "Missense de novo variants in the CACNA1A associated with severe early onset ataxias can be gain or loss of function in Drosophila.." PLoS Genet.. 2017;13:e1006905.
- Schoch K, Meng L, Szelinger S, Bearden DR, Stray-Pedersen A, (...), Wangler MF*, Shashi V* "A Recurrent de novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts and Profound Developmental Delay." Am J Hum Genet.. 2017;100:343-351.
- Wangler MF*, Chao YH, Bayat V, Giagtzoglu N, Putluri, N, (...), Bellen HJ "Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.." PLoS Genet. 2017;13:e1006825.
- Yoon WH, Sandoval H, Nagarkar Jaiswal S, Jaiswal M, Yamamoto S, (...), Wangler MF, Karaca E, Lupski JR, Bellen HJ "Nardilysin chaperones mitochondrial Oxoglutarate dehydrogenase and protects against the demise of neurons in flies and human." Neuron. 2017;93:115-131.
- Chao H-T, Davids M, Burke E, Pappas JG, Rosenfeld JA, (...), Wangler MF* Malicdan MC* "A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3." Am J Hum Genet.. 2017;100:128-137.
- Ventura MJ, Wheaton D, Xu M, Birch D, Bowne SJ, (...), Wangler MF "Diagnosis of a mild peroxisomal phenotype with next-generation sequencing.." Mol Genet Metab Rep. 2016;9:75-78.
- Chao Y-H, Robak L, Xia F, Koenig M, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF "Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila." Hum Mol Genet. 2016;25:1846-56. Pubmed PMID: 26931468
- Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF, Hacia JG, Bose M "Peroxisome Biogenesis Disorders in the Zellweger Spectrum: an overview of current diagnosis, clinical manifestations and treatment guidelines." Mol Genet Metab. 2015;117:313-21. Pubmed PMID: 26750748
- Bacino C, Chao Y-H, Seto E, Lotze T, Xia F, Moser A, Wangler MF "A homozygous mutation in PEX16 identified by whole-exome sequencing ending a diagnostic odyssey." Mol Genet Metab Rep. 2015;5:15-18. Pubmed PMID: 26644994
- Wangler MF, Beaudet AL "ACTG2-Related Disorders." GeneReviews [Internet]. 2015;
- Wangler, MF, Yamamoto S, Bellen, H "Fruit flies in Biomedical Research." Genetics. 2015;199:639-53. Pubmed PMID: 25624315
- Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, (...), Gibbs RA, Chen R, Lupski JR, Wangler MF*, Bellen HJ* "A Drosophila genetic resource to study human disease genes and its use for gene discovery in human exome data." Cell. 2014;159:200-14. Pubmed PMID: 25259927
- Faust, JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler MF, Stern M, McNew JA "Peroxisomes are Required for Lipid Metabolism and Muscle Function in Drosophila melanogaster." PLOS One. 2014;9:e100213. Pubmed PMID: 24945818
- Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, (...), Gibbs RA, Lupski JR, Beaudet A "Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome." PLOS Genet. 2014;10:e1004258. Pubmed PMID: 24676022
- Wangler MF, Chavan R, Hicks MJ, Nuchtern JG, Hegde M, Plon SE, Thompson PA "Unusually early presentation of small-bowel adenocarcinoma in a patient with Peutz-Jeghers syndrome." J Pediatr Hematol Oncol. 2013 May;35(4):323-8. Pubmed PMID: 23426006
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