Michael
Middle Name
Francis
Wangler, M.D.
Middle Name
Francis
Picture
Positions
- Assistant Professor
-
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX US
- Faculty Member
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Graduate Programs in Development, Disease Models & Therapeutics and Genetics & Genomics
Baylor College of Medicine
Addresses
- Texas Children's Genetics Clinic (Clinic)
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Texas Children's Clinical Care Center
6701 Fannin St., 16th Floor
Houston, TX 77030
United States
Phone: (832) 822-4280
Texas Children's Genetics Clinic
- Duncan Neurological Research Institute (Lab)
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Room: DNRI-1050
Houston, TX 77030
United States
Phone: (832) 822-1240
michael.wangler@bcm.edu
Education
- MD from Baylor College Of Medicine
- Houston, TX United States
- Internship at Baylor College Of Medicine Affiliate Hospitals
- Houston, TX United States
- Pediatrics
- Residency at Baylor College Of Medicine Affiliate Hospitals
- Houston, TX
- Pediatrics
- Residency at Baylor College Of Medicine Affiliate Hospitals
- Houston, TX
- Clinical Genetics
Certifications
- American Board of Pediatrics
- American Board of Medical Genetics
Professional Interests
- Pediatric genetics
- Peroxisomal disorders
Professional Statement
Molecular and Developmental Mechanisms of Mendelian DisordersOur lab studies rare human disease phenotypes in order to gain insight into general principles of human health. Methods include clinical observations, genomics and studies in model organisms, particularly Drosophila melanogaster. We are currently using Drosophila to study Mendelian disorders and their underlying genetic and developmental mechanisms in two major efforts:
1) Model Organisms and the Molecular Pathogenesis of Mendelian Disorders: We use Drosophila models for diagnostic paradigms. We are part of the Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN). We have also started a similar effort in underserved populations.
2) Mendelian Disorders of the Peroxisome and Organelle Dynamics: Peroxisomes are fundamental sub-cellular organelles present in all eukaryotic cells. We use clinical and Drosophila studies in the elucidation of mechanisms of Peroxisomal Biogenesis Disorders- Zellweger Spectrum disorders (PBD-ZSD). These diseases are expanding from autosomal recessive disorders to a broad range of human disease related to peroxisomes.
Websites
Selected Publications
- Schulze KV, Hanchard NA, Wangler MF* "Biases in arginine codon usage correlate with genetic disease risk.." Genet Med. 2020 22 : 1407-1412.
- Assia Batzir N, Kishor Bhagwat P, Larson A, Coban Akdemir Z, Bagłaj M, (…) Baylor-Hopkins Center for Mendelian Genomics, Posey JE, Lupski JR, Beaudet AL, Wangler MF* "Recurrent arginine substitutions in the ACTG2 gene are the primary driver of disease burden and severity in visceral myopathy.." Hum Mutat.. 2020 41 : 641-654.
- Graves HK, Jangam S, Tan KL, Pignata A, Seto ES, Yamamoto S, Wangler MF* "A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease.." G3 (Bethesda). 2020 10 : 69-77.
- Assia Batzir N, Bhagwat PK, Eble TN, Liu P, Eng CM, (…) Wangler MF* "De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.." Cold Spring Harb Mol Case Stud.. 2019 5 : a003673.
- Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, (…) Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA "Undiagnosed Diseases Network. Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.." N Engl J Med.. 2018 379 : 2131-2139.
- Wangler MF*, Hubert L, Donti TR, Ventura MJ, Miller MJ, (…) Elsea SH "A metabolomic map of Zellweger spectrum disorders reveals novel disease biomarkers.." Genet Med.. 2018 20 : 1274-1283.
- Wangler MF, Yamamoto S, Chao HT, Posey JE, Westerfield M, (…) Bellen HJ "Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research.." Genetics. 2017 207 : 9-27.
- Luo X, Rosenfeld JA, Yamamoto S, Harel T, Pastore M, (...), Members of the UDN, Lotze T, Lupski JR, Lalani S, Yang Y, Lee B, Bellen HJ, Wangler MF "Missense de novo variants in the CACNA1A associated with severe early onset ataxias can be gain or loss of function in Drosophila.." PLoS Genet.. 2017 13 : e1006905.
- Schoch K, Meng L, Szelinger S, Bearden DR, Stray-Pedersen A, (...), Wangler MF*, Shashi V* "A Recurrent de novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts and Profound Developmental Delay." Am J Hum Genet.. 2017 100 : 343-351.
- Wangler MF*, Chao YH, Bayat V, Giagtzoglu N, Putluri, N, (...), Bellen HJ "Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.." PLoS Genet. 2017 13 : e1006825.
- Yoon WH, Sandoval H, Nagarkar Jaiswal S, Jaiswal M, Yamamoto S, (...), Wangler MF, Karaca E, Lupski JR, Bellen HJ "Nardilysin chaperones mitochondrial Oxoglutarate dehydrogenase and protects against the demise of neurons in flies and human." Neuron. 2017 93 : 115-131.
- Chao H-T, Davids M, Burke E, Pappas JG, Rosenfeld JA, (...), Wangler MF* Malicdan MC* "A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3." Am J Hum Genet.. 2017 100 : 128-137.
- Ventura MJ, Wheaton D, Xu M, Birch D, Bowne SJ, (...), Wangler MF "Diagnosis of a mild peroxisomal phenotype with next-generation sequencing.." Mol Genet Metab Rep. 2016 9 : 75-78.
- Chao Y-H, Robak L, Xia F, Koenig M, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF "Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila." Hum Mol Genet. 2016 25 : 1846-56. Pubmed PMID: 26931468
- Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF, Hacia JG, Bose M "Peroxisome Biogenesis Disorders in the Zellweger Spectrum: an overview of current diagnosis, clinical manifestations and treatment guidelines." Mol Genet Metab. 2015 117 : 313-21. Pubmed PMID: 26750748
- Bacino C, Chao Y-H, Seto E, Lotze T, Xia F, Moser A, Wangler MF "A homozygous mutation in PEX16 identified by whole-exome sequencing ending a diagnostic odyssey." Mol Genet Metab Rep. 2015 5 : 15-18. Pubmed PMID: 26644994
- Wangler MF, Beaudet AL "ACTG2-Related Disorders." GeneReviews [Internet]. 2015 :
- Wangler, MF, Yamamoto S, Bellen, H "Fruit flies in Biomedical Research." Genetics. 2015 199 : 639-53. Pubmed PMID: 25624315
- Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, (...), Gibbs RA, Chen R, Lupski JR, Wangler MF*, Bellen HJ* "A Drosophila genetic resource to study human disease genes and its use for gene discovery in human exome data." Cell. 2014 159 : 200-14. Pubmed PMID: 25259927
- Faust, JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler MF, Stern M, McNew JA "Peroxisomes are Required for Lipid Metabolism and Muscle Function in Drosophila melanogaster." PLOS One. 2014 9 : e100213. Pubmed PMID: 24945818
- Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, (...), Gibbs RA, Lupski JR, Beaudet A "Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome." PLOS Genet. 2014 10 : e1004258. Pubmed PMID: 24676022
- Wangler MF, Chavan R, Hicks MJ, Nuchtern JG, Hegde M, Plon SE, Thompson PA "Unusually early presentation of small-bowel adenocarcinoma in a patient with Peutz-Jeghers syndrome." J Pediatr Hematol Oncol. 2013 May ; 35 (4): 323-8. Pubmed PMID: 23426006
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