Positions

Professor

Pediatrics-Cardiology
Baylor College of Medicine
Houston, Texas, United States

Addresses

Texas Children's Hospital (Office)

Legacy Tower
6651 Main Street, Suite E1960.24
Houston, TX, 77030
United States
Phone: (832) 826-5600

Texas Children's Hospital (Clinic)

Legacy Tower
6651 Main Street
Houston, TX, 77030
United States

Education

Fellowship at Baylor College Of Medicine

Houston, Texas, United States

Pediatric Electrophysiology

Fellowship at Baylor College of Medicine

01/2005 - Houston, Texas, United States

Pediatric Cardiology

Residency at University of Illinois at Chicago

01/2002 - Chicago, Illinois, United States

Pediatrics

MD from University Of Illinois, Chicago Circle

01/1999 - Chicago, Illinois, United States

Certifications

American Board of Pediatrics

American Board of Pediatrics-Sub Board of Pediatric Cardiology

Professional Interests

• Molecular mechanisms of sudden death and arrhythmias in heart failure

Websites

Selected Publications

• Pangas SA, Woodruff TK. " Activin signal transduction pathways. " Trends Endocrinol. Metab.. 2000 Oct ; 11 (8) : 309-14.
  Pubmed PMID: 10996525.
• Macicek SM, Macias CG, Jefferies JL, Kim JJ, Price JF. " Acute heart failure syndromes in the pediatric emergency department. " Pediatrics. 2009 Nov ; 124 (5) : e898-904.
  Pubmed PMID: 19841123.
• Kim JJ, Dreyer WJ, Chang AC, Breinholt JP, Grifka RG. " Arterial pulse wave analysis: An accurate means of determining cardiac output in children. " Pediatr Crit Care Med. 2006 Nov ; 7 (6) : 532-5.
  Pubmed PMID: 17006382.
• Rossano JW, Denfield SW, Kim JJ, Price JF, Jefferies JL, Decker JA, Smith EO, Clunie SK, Towbin JA, Dreyer WJ. " Assessment of the Cylex ImmuKnow cell function assay in pediatric heart transplant patients. " J. Heart Lung Transplant.. 2009 Jan ; 28 (1) : 26-31.
  Pubmed PMID: 19134527.
• Sinha A, Fernandes CJ, Kim JJ, Fenrich AL, Enciso J. " Atrial flutter following placement of an umbilical venous catheter. " Am J Perinatol. 2005 Jul ; 22 (5) : 275-7.
  Pubmed PMID: 16041639.
• Rossano JW, Denfield SW, Kim JJ, Price JF, Jefferies JL, Decker JA, Smith EO, Clunie SK, Towbin JA, Dreyer WJ. " B-type natriuretic peptide is a sensitive screening test for acute rejection in pediatric heart transplant patients. " J. Heart Lung Transplant.. 2008 Jun ; 27 (6) : 649-54.
  Pubmed PMID: 18503965.
• Tripurani SK, Cook RW, Eldin KW, Pangas SA. " BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors. " Oncogene. 2012 Sep 10;
  Pubmed PMID: 22964636.
• Pangas SA. " Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells. " Mol. Cell. Endocrinol.. 2012 Jun 5; 356 (41276) : 40-7.
  Pubmed PMID: 21763749.
• Suzumori N, Pangas SA, Rajkovic A. " Candidate genes for premature ovarian failure. " Curr. Med. Chem.. 2007 ; 14 (3) : 353-7.
  Pubmed PMID: 17305537.
• Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, Wang D, Martin JF, Jamin SP, Behringer RR, Robertson EJ, Matzuk MM. " Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. " Mol. Cell. Biol.. 2008 Jan ; 28 (1) : 248-57.
  Pubmed PMID: 17967875.
• Shah AM, Cannon BC, Kertesz NJ, Kim JJ. " Cross-stimulation: a rare complication of chronic epicardial leads. " J. Cardiovasc. Electrophysiol.. 2009 Sep ; 20 (9) : 1065-7.
  Pubmed PMID: 19207786.
• Nagaraja AK, Middlebrook BS, Rajanahally S, Myers M, Li Q, Matzuk MM, Pangas SA. " Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice. " Endocrinology. 2010 Oct ; 151 (10) : 4994-5006.
  Pubmed PMID: 20739397.
• Rossano JW, Grenier MA, Dreyer WJ, Kim JJ, Price JF, Jefferies JL, Smith EO, Clunie SK, Moulik M, Decker JA, Breinholt JP, Morales DL, McKenzie ED, Towbin JA, Denfield SW. " Effect of body mass index on outcome in pediatric heart transplant patients. " J. Heart Lung Transplant.. 2007 Jul ; 26 (7) : 718-23.
  Pubmed PMID: 17613403.
• Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. " Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. " Heart Rhythm. 2010 Oct ; 7 (10) : 1484-8.
  Pubmed PMID: 20601155.
• Wilmot I, Morales DL, Price JF, Rossano JW, Kim JJ, Decker JA, McGarry MC, Denfield SW, Dreyer WJ, Towbin JA, Jefferies JL. " Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. " J. Card. Fail.. 2011 Jun ; 17 (6) : 487-94.
  Pubmed PMID: 21624737.
• Bryant R, Aboutalebi A, Kim JJ, Kertesz N, Morales DL. " Epicardial implantable cardioverter-defibrillator system placed in a 4.9-kg infant. " Tex Heart Inst J. 2011 ; 38 (4) : 421-3.
  Pubmed PMID: 21841874.
• Pangas SA, Matzuk MM. " Genetic models for transforming growth factor beta superfamily signaling in ovarian follicle development. " Mol. Cell. Endocrinol.. 2004 Oct 15; 225 (41276) : 83-91.
  Pubmed PMID: 15451572.
• Edson MA, Nalam RL, Clementi C, Franco HL, Demayo FJ, Lyons KM, Pangas SA, Matzuk MM. " Granulosa Cell-Expressed BMPR1A and BMPR1B Have Unique Functions in Regulating Fertility but Act Redundantly to Suppress Ovarian Tumor Development. " Mol. Endocrinol.. 2010 Jun ; 24 (6) : 1251-66.
  Pubmed PMID: 20363875.
• Pangas SA, Jorgez CJ, Matzuk MM. " Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin. " J. Biol. Chem.. 2004 Jul 30; 279 (31) : 32281-6.
  Pubmed PMID: 15133038.
• Pangas SA. " Growth factors in ovarian development. " Semin. Reprod. Med.. 2007 Jul ; 25 (4) : 225-34.
  Pubmed PMID: 17594603.
• Knudson JD, Cannon BC, Kim JJ, Moffett BS. " High-dose sotalol is safe and effective in neonates and infants with refractory supraventricular tachyarrhythmias. " Pediatr Cardiol. 2011 Oct ; 32 (7) : 896-903.
  Pubmed PMID: 21553267.
• Lopez KN, Decker JA, Friedman RA, Kim JJ. " Homozygous mutation in SCN5A associated with atrial quiescence, recalcitrant arrhythmias, and poor capture thresholds. " Heart Rhythm. 2011 Mar ; 8 (3) : 471-3.
  Pubmed PMID: 20950709.
• McKenzie LJ, Pangas SA, Carson SA, Kovanci E, Cisneros P, Buster JE, Amato P, Matzuk MM. " Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. " Hum. Reprod.. 2004 Dec ; 19 (12) : 2869-74.
  Pubmed PMID: 15471935.
• Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. " Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: an analysis of the United Network for Organ Sharing database. " J. Thorac. Cardiovasc. Surg.. 2010 Sep ; 140 (3) : 694-9, 699.e1-2.
  Pubmed PMID: 20537356.
• Thomas PE, Carlo WF, Decker JA, Cannon BC, Kertesz NJ, Friedman RA, Kim JJ. " Impact of the American Heart Association scientific statement on screening electrocardiograms and stimulant medications. " Arch Pediatr Adolesc Med. 2011 Feb ; 165 (2) : 166-70.
  Pubmed PMID: 21300657.
• Pangas SA, Jorgez CJ, Tran M, Agno J, Li X, Brown CW, Kumar TR, Matzuk MM. " Intraovarian activins are required for female fertility. " Mol. Endocrinol.. 2007 Oct ; 21 (10) : 2458-71.
  Pubmed PMID: 17609433.
• Kim JJ, Valdes SO, Kertesz NJ, Cannon BC. " Isolated junctional tachycardia in a patient with pheochromocytoma: an unusual presentation of an uncommon disease. " Pediatr Cardiol. 2008 Sep ; 29 (5) : 986-8.
  Pubmed PMID: 17990020.
• Kim JJ, Dreyer WJ, O'Brian Smith E, Price JF, Clunie S, Dimas VV, Jefferies JL, Rosenblatt H, Radovancevic B, Towbin JA, Denfield SW. " Leukocyte suppression is associated with improved clinical outcomes in children's status after orthotopic heart transplantation. " J. Heart Lung Transplant.. 2006 Feb ; 25 (2) : 195-9.
  Pubmed PMID: 16446220.
• Kyle WB, Macicek SL, Lindle KA, Kim JJ, Cannon BC. " Limited utility of exercise stress tests in the evaluation of children with chest pain. " Congenit Heart Dis. 2012 Sep ; 7 (5) : 455-9.
  Pubmed PMID: 22883642.
• Pangas SA, Rademaker AW, Fishman DA, Woodruff TK. " Localization of the activin signal transduction components in normal human ovarian follicles: implications for autocrine and paracrine signaling in the ovary. " J. Clin. Endocrinol. Metab.. 2002 Jun ; 87 (6) : 2644-57.
  Pubmed PMID: 12050229.
• Myers M, Tripurani SK, Middlebrook B, Economides AN, Canalis E, Pangas SA. " Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice. " Biol. Reprod.. 2011 Dec ; 85 (6) : 1175-82.
  Pubmed PMID: 21832168.
• Myers M, Middlebrook BS, Matzuk MM, Pangas SA. " Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis. " Dev. Biol.. 2009 Oct 15; 334 (2) : 458-67.
  Pubmed PMID: 19666016.
• Kim JJ, Macicek SL, Decker JA, Kertesz NJ, Friedman RA, Cannon BC. " Magnetic versus manual catheter navigation for ablation of free wall accessory pathways in children. " Circ Arrhythm Electrophysiol. 2012 Aug 1; 5 (4) : 804-8.
  Pubmed PMID: 22628518.
• Kim JJ, Valdes SO, Kertesz NJ, Friedman RA, Lewellen M, Domino M, Cannon BC. " Maintenance of AV synchrony in a small child utilizing two pacemakers and the triggered VVT mode: triggered pacing in small children. " Pacing Clin Electrophysiol. 2007 Nov ; 30 (11) : 1404-7.
  Pubmed PMID: 17976108.
• Kim JJ, Denfield SW, McKenzie ED, Fraser CD, Heinle JS, Goldstein S, Towbin JA, Dreyer WJ. " Mechanical circulatory support as a bridge to combined dual organ transplantation in children. " J. Heart Lung Transplant.. 2006 Dec ; 25 (12) : 1480-2.
  Pubmed PMID: 17178345.
• Yan W, Ma L, Stein P, Pangas SA, Burns KH, Bai Y, Schultz RM, Matzuk MM. " Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. " Mol. Cell. Biol.. 2005 Jun ; 25 (11) : 4615-24.
  Pubmed PMID: 15899864.
• Li X, Tripurani SK, James R, Pangas SA. " Minimal fertility defects in mice deficient in oocyte-expressed smad4. " Biol. Reprod.. 2012 ; 86 (1) : 41280.
  Pubmed PMID: 21900682.
• Brescia ST, Rossano JW, Pignatelli R, Jefferies JL, Price JF, Decker JA, Denfield SW, Dreyer WJ, Smith O, Towbin JA, Kim JJ. " Mortality and sudden death in pediatric left ventricular noncompaction in a tertiary referral center. " Circulation. 2013 Jun 4; 127 (22) : 2202-8.
  Pubmed PMID: 23633270.
• Richards JS, Pangas SA. " New insights into ovarian function. " Handb Exp Pharmacol. 2010 ; 198 : 41360.
  Pubmed PMID: 20839083.
• Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. " NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. " Science. 2004 Aug 20; 305 (5687) : 1157-9.
  Pubmed PMID: 15326356.
• Pangas SA, Saudye H, Shea LD, Woodruff TK. " Novel approach for the three-dimensional culture of granulosa cell-oocyte complexes. " Tissue Eng.. 2003 Oct ; 9 (5) : 1013-21.
  Pubmed PMID: 14633385.
• Su YQ, Sugiura K, Wigglesworth K, O'Brien MJ, Affourtit JP, Pangas SA, Matzuk MM, Eppig JJ. " Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells. " Development. 2008 Jan ; 135 (1) : 111-21.
  Pubmed PMID: 18045843.
• Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ. " Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. " Development. 2007 Jul ; 134 (14) : 2593-603.
  Pubmed PMID: 17553902.
• Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A. " Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. " Proc. Natl. Acad. Sci. U.S.A.. 2006 May 23; 103 (21) : 8090-5.
  Pubmed PMID: 16690745.
• Shamszad P, Cabrera AG, Kim JJ, Moffett BS, Graves DE, Heinle JS, Rossano JW. " Perioperative atrial tachycardia is associated with increased mortality in infants undergoing cardiac surgery. " J. Thorac. Cardiovasc. Surg.. 2012 Aug ; 144 (2) : 396-401.
  Pubmed PMID: 22306216.
• Jurivich DA, Pangas S, Qiu L, Welk JF. " Phospholipase A2 triggers the first phase of the thermal stress response and exhibits cell-type specificity. " J. Immunol.. 1996 Aug 15; 157 (4) : 1669-77.
  Pubmed PMID: 8759754.
• Pangas SA, Li X, Robertson EJ, Matzuk MM. " Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice. " Mol. Endocrinol.. 2006 Jun ; 20 (6) : 1406-22.
  Pubmed PMID: 16513794.
• Pangas SA, Woodruff TK. " Production and purification of recombinant human inhibin and activin. " J. Endocrinol.. 2002 Jan ; 172 (1) : 199-210.
  Pubmed PMID: 11786387.
• Kim JJ, Denfield SW, Dreyer WJ, Price JF, Cannon BC, Towbin JA, Minor M, Clunie S, Kertesz NJ. " Radio-frequency catheter ablation of accessory pathway mediated tachycardia in a child after orthotopic heart transplantation. " J. Heart Lung Transplant.. 2005 Sep ; 24 (9) : 1444.
  Pubmed PMID: 16143270.
• Li Q, Pangas SA, Jorgez CJ, Graff JM, Weinstein M, Matzuk MM. " Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. " Mol. Cell. Biol.. 2008 Dec ; 28 (23) : 7001-11.
  Pubmed PMID: 18809571.
• Pangas SA. " Regulation of the ovarian reserve by members of the transforming growth factor beta family. " Mol. Reprod. Dev.. 2012 Jul 27;
  Pubmed PMID: 22847922.
• Myers M, Pangas SA. " Regulatory roles of transforming growth factor beta family members in folliculogenesis. " Wiley Interdiscip Rev Syst Biol Med. 2010 Jan ; 2 (1) : 117-25.
  Pubmed PMID: 20836015.
• Pangas SA, Yan W, Matzuk MM, Rajkovic A. " Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. " Gene Expr. Patterns. 2004 Dec ; 5 (2) : 257-63.
  Pubmed PMID: 15567723.
• Maskatia SA, Decker JA, Spinner JA, Kim JJ, Price JF, Jefferies JL, Dreyer WJ, Smith EO, Rossano JW, Denfield SW. " Restrictive Physiology is Associated With Poor Outcomes in Children With Hypertrophic Cardiomyopathy. " Pediatr Cardiol. 2012 Jan ; 33 (1) : 141-9.
  Pubmed PMID: 21892651.
• Morales DL, Zafar F, Heinle JS, Ocampo EC, Kim JJ, Relyea K, Fraser CD. " Right Ventricular Infundibulum Sparing (RVIS) Tetralogy of Fallot Repair: A Review of Over 300 Patients. " Ann. Surg.. 2009 Oct ; 250 (4) : 611-7.
  Pubmed PMID: 19734777.
• Decker JA, Rossano JW, Smith EO, Cannon B, Clunie SK, Gates C, Jefferies JL, Kim JJ, Price JF, Dreyer WJ, Towbin JA, Denfield SW. " Risk factors and mode of death in isolated hypertrophic cardiomyopathy in children. " J. Am. Coll. Cardiol.. 2009 Jul 14; 54 (3) : 250-4.
  Pubmed PMID: 19589438.
• Middlebrook BS, Eldin K, Li X, Shivasankaran S, Pangas SA. " Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors. " Endocrinology. 2009 Dec ; 150 (12) : 5208-17.
  Pubmed PMID: 19819941.
• Szigeti R, Pangas SA, Nagy-Szakal D, Dowd SE, Shulman RJ, Olive AP, Popek EJ, Finegold MJ, Kellermayer R. " SMAD4 Haploinsufficiency Associates with Augmented Colonic Inflammation in Select Humans and Mice. " Ann. Clin. Lab. Sci.. 2012 ; 42 (4) : 401-8.
  Pubmed PMID: 23090737.
• Ballow DJ, Xin Y, Choi Y, Pangas SA, Rajkovic A. " Sohlh2 is a germ cell-specific bHLH transcription factor. " Gene Expr. Patterns. 2006 Oct ; 6 (8) : 1014-8.
  Pubmed PMID: 16765102.
• Chong H, Pangas SA, Bernard DJ, Wang E, Gitch J, Chen W, Draper LB, Cox ET, Woodruff TK. " Structure and expression of a membrane component of the inhibin receptor system. " Endocrinology. 2000 Jul ; 141 (7) : 2600-7.
  Pubmed PMID: 10875264.
• Pangas SA, Matzuk MM. " The art and artifact of GDF9 activity: cumulus expansion and the cumulus expansion-enabling factor. " Biol. Reprod.. 2005 Oct ; 73 (4) : 582-5.
  Pubmed PMID: 15917343.
• Richards JS, Pangas SA. " The ovary: basic biology and clinical implications. " J. Clin. Invest.. 2010 Apr 1; 120 (4) : 963-72.
  Pubmed PMID: 20364094.
• Jefferies JL, Kim JJ, Belmont JW, Friedman RA. " The Twiddling Andersen. " Tex Heart Inst J. 2009 ; 36 (4) : 349-51.
  Pubmed PMID: 19693314.
• Pangas SA, Rajkovic A. " Transcriptional regulation of early oogenesis: in search of masters. " Hum. Reprod. Update. ; 12 (1) : 65-76.
  Pubmed PMID: 16143663.
• Crittendon I, Dreyer WJ, Decker JA, Kim JJ. " Ultrasound dilution: An accurate means of determining cardiac output in children*. " Pediatr Crit Care Med. 2012 Jan ; 13 (1) : 42-6.
  Pubmed PMID: 21499176.
• Kim JJ, Friedman RA, Eidem BW, Cannon BC, Arora G, Smith EO, Fenrich AL, Kertesz NJ. " Ventricular function and long-term pacing in children with congenital complete atrioventricular block. " J. Cardiovasc. Electrophysiol.. 2007 Apr ; 18 (4) : 373-7.
  Pubmed PMID: 17394451.

Show 62 more publications

Memberships

Pediatric & Congenital Electrophysiology Society

Heart Rhythm Society

Heart Failure Society of America

American College of Cardiology

American Academy of Pediatrics