George Gerald Rodney Jr., Ph.D.

Associate Professor

(713) 798-5797

Email

rodney@bcm.edu

Positions

Associate Professor: Integrative Physiology
Baylor College of Medicine
Houston, TX, US

Education

Post-Doctoral Fellowship at University Of Maryland At Baltimore: 01/2004 - Baltimore, Maryland, United States

PhD from Baylor College Of Medicine: 01/2001 - Houston, Texas, United States

MS from University Of Texas Health Science Center: 01/1996 - San Antonia, Texas, United States

Professional Interests

Biomedical Imaging
Cardiovascular Sciences
Cell and Developmental Biology
Human Disease
Skeletal Muscle Physiology

Professional Statement

Real-time imaging of sub-cellular reactive oxygen species, Ca2+ signaling, and excitation-contraction coupling in skeletal muscle under physiological and pathophysiological conditions.

Websites

Rodney Lab Web Site

VIICTR - Publications

Selected Publications

Pal,Rituraj; Palmieri,Michela; Loehr,James A.; Li,Shumin; Abo-Zahrah,Reem; Monroe,Tanner O.; Thakur,Poulami B.; Sardiello,Marco; Rodney,George G.. " Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy " Nat Commun. 2014 ; 5 : 5425.
Pubmed PMID: 25028121.
Pal,Rituraj; Monroe,Tanner O.; Palmieri,Michela; Sardiello,Marco; Rodney,George G.. " Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells. " FEBS Lett. 2014 Jan ; 588 (3) : 472-481.
Pal R, Basu Thakur P, Li S, Minard C, Rodney GG. " Real-time imaging of NADPH oxidase activity in living cells using a novel fluorescent protein reporter. " PLoS ONE. 2013 ; 8 (5) : e63989.
Pubmed PMID: 23704967.
Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. " AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. " Nat. Med.. 2012 ; 18 (2) : 244-51.
Pubmed PMID: 22231556.
Schneider MF, Rodney GG, Ward CW. " Local Ca2+ release events in skeletal muscle. " J. Muscle Res. Cell. Motil.. 2004 ; 25 (8) : 587-9.
Pubmed PMID: 16118845.
Bisnett T, Anzueto A, Andrade FH, Rodney GG, Napier WR, Levine SM, Maxwell LC, Mureeba P, Derdak SD, Grisham MB, Jenkinson SG. " Effect of nitric oxide synthase inhibitor on diaphragmatic function after resistive loading. " Comp. Biochem. Physiol., Part A Mol. Integr. . 1998 Jan ; 119 (1) : 185-90.
Pubmed PMID: 11253784.
Rodney GG, Schneider MF. " Calmodulin modulates initiation but not termination of spontaneous Ca2+ sparks in frog skeletal muscle. " Biophys. J.. 2003 Aug ; 85 (2) : 921-32.
Pubmed PMID: 12885639.
Rodney GG, Williams BY, Strasburg GM, Beckingham K, Hamilton SL. " Regulation of RYR1 activity by Ca(2+) and calmodulin. " Biochemistry. 2000 Jul 4; 39 (26) : 7807-12.
Pubmed PMID: 10869186.
Moore CP, Rodney G, Zhang JZ, Santacruz-Toloza L, Strasburg G, Hamilton SL. " Apocalmodulin and Ca2+ calmodulin bind to the same region on the skeletal muscle Ca2+ release channel. " Biochemistry. 1999 Jun 29; 38 (26) : 8532-7.
Pubmed PMID: 10387100.
Brown LD, Rodney GG, Hernández-Ochoa E, Ward CW, Schneider MF. " Ca2+ sparks and T tubule reorganization in dedifferentiating adult mouse skeletal muscle fibers. " Am. J. Physiol., Cell Physiol.. 2007 Mar ; 292 (3) : C1156-66.
Pubmed PMID: 17065203.
Rodney GG, Wilson GM, Schneider MF. " A calmodulin binding domain of RyR increases activation of spontaneous Ca2+ sparks in frog skeletal muscle. " J. Biol. Chem.. 2005 Mar 25; 280 (12) : 11713-22.
Pubmed PMID: 15640144.
Rodney GG, Moore CP, Williams BY, Zhang JZ, Krol J, Pedersen SE, Hamilton SL. " Calcium binding to calmodulin leads to an N-terminal shift in its binding site on the ryanodine Receptor. " J. Biol. Chem.. 2001 Jan 19; 276 (3) : 2069-74.
Pubmed PMID: 11035044.
Rodney GG. " Calmodulin in adult mammalian skeletal muscle: localization and effect on sarcoplasmic reticulum Ca2+ release. " Am. J. Physiol., Cell Physiol.. 2008 May ; 294 (5) : C1288-97.
Pubmed PMID: 18322139.
Pate P, Mochca-Morales J, Wu Y, Zhang JZ, Rodney GG, Serysheva II, Williams BY, Anderson ME, Hamilton SL. " Determinants for calmodulin binding on voltage-dependent Ca2+ channels. " J. Biol. Chem.. 2000 Dec 15; 275 (50) : 39786-92.
Pubmed PMID: 11005820.
Ward CW, Rodney GG. " Does a lack of RyR3 make mammalian skeletal muscle EC coupling a 'spark-less' affair? " J. Physiol. (Lond.). 2008 Jan 15; 586 (2) : 313-4.
Pubmed PMID: 18192614.
Zhang Y, Rodney GG, Schneider MF. " Effects of azumolene on Ca2+ sparks in skeletal muscle fibers. " J. Pharmacol. Exp. Ther.. 2005 Jul ; 314 (1) : 94-102.
Pubmed PMID: 15831441.
Xiong LW, Newman RA, Rodney GG, Thomas O, Zhang JZ, Persechini A, Shea MA, Hamilton SL. " Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin. " J. Biol. Chem.. 2002 Oct 25; 277 (43) : 40862-70.
Pubmed PMID: 12185083.
Michaelson LP, Shi G, Ward CW, Rodney GG. " Mitochondrial redox potential during contraction in single intact muscle fibers. " Muscle Nerve. 2010 Oct ; 42 (4) : 522-9.
Pubmed PMID: 20730875.
Zhang JZ, Wu Y, Williams BY, Rodney G, Mandel F, Strasburg GM, Hamilton SL. " Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding. " Am. J. Physiol.. 1999 Jan ; 276 (1) : C46-53.
Pubmed PMID: 9886919.
Schneider MF, Rodney GG. " Peptide and protein modulation of local Ca2+ release events in permeabilized skeletal muscle fibers. " Biol. Res.. 2004 ; 37 (4) : 613-6.
Pubmed PMID: 15709689.
Ziman AP, Ward CW, Rodney GG, Lederer WJ, Bloch RJ. " Quantitative measurement of Ca²(+) in the sarcoplasmic reticulum lumen of mammalian skeletal muscle. " Biophys. J.. 2010 Oct 20; 99 (8) : 2705-14.
Pubmed PMID: 20959112.
Rodney GG, Krol J, Williams B, Beckingham K, Hamilton SL. " The carboxy-terminal calcium binding sites of calmodulin control calmodulin's switch from an activator to an inhibitor of RYR1. " Biochemistry. 2001 Oct 16; 40 (41) : 12430-5.
Pubmed PMID: 11591164.