George Carrum, M.D.

Professor

Email

gcarrum@bcm.edu

Positions

Professor: Center for Gene Therapy
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Houston Methodist Hospital (Clinic): 6565 Fannin St., Suite 800
Houston, TX, 77030
United States
Phone: (713) 441-1450

Professional Interests

Peripheral blood stem cell and bone marrow transplantation

Professional Statement

Dr. Carrum's current clinical interests include high dose chemotherapy and stem cell rescue for multiple myeloma, amyloidosis, lymphoma and leukemia. He is interested in post-transplant immunotherapy for multiple myeloma and submyeloablative regimens with allogenic stem cell rescue for patients with malignant diseases.

Websites

VIICTR Publications List

Selected Publications

Lamba R, Carrum G, Myers GD, Bollard CM, Krance RA, Heslop HE, Brenner MK, Popat U. " Cytomegalovirus (CMV) infections and CMV-specific cellular immune reconstitution following reduced intensity conditioning allogeneic stem cell transplantation with Alemtuzumab. " Bone Marrow Transplant.. 2005 Nov ; 36 (9) : 797-802.
Pubmed PMID: 16151431.
Kamble RT, Guo S, Ramos CA, Carrum G. " Acute gout at engraftment following hematopoietic transplantation. " Am. J. Hematol.. 2011 Nov ; 86 (11) : 961-2.
Pubmed PMID: 21948346.
Bollard CM, Huls MH, Buza E, Weiss H, Torrano V, Gresik MV, Chang J, Gee A, Gottschalk SM, Carrum G, Brenner MK, Rooney CM, Heslop HE. " Administration of latent membrane protein 2-specific cytotoxic T lymphocytes to patients with relapsed Epstein-Barr virus-positive lymphoma. " 2006 Jan ; 6 (4) : 342-7.
Pubmed PMID: 16507214.
Roskrow MA, Rooney CM, Heslop HE, Brenner MK, Krance RA, Gresik MV, McClain K, Aguilar LK, Grilley B, Rob E, Carrum G. " Administration of neomycin resistance gene marked EBV specific cytotoxic T-lymphocytes to patients with relapsed EBV-positive Hodgkin disease. " Hum. Gene Ther.. 1998 May 20; 9 (8) : 1237-50.
Pubmed PMID: 9625264.
Heslop H, Rooney C, Brenner M, Krance R, Carrum G, Gahn B, Bollard C, Khan S, Gee A, Popat U, Gresik M, Przepiorka D, Kuehnle I, Grilley B. " Administration of neomycin resistance gene-marked EBV-specific cytotoxic T-lymphocytes as therapy for patients receiving a bone marrow transplant for relapsed EBV-positive Hodgkin disease. " Hum. Gene Ther.. 2000 Jul 1; 11 (10) : 1465-75.
Pubmed PMID: 10910143.
Samuelson S, Sandmaier BM, Heslop HE, Popat U, Carrum G, Champlin RE, Storb R, Prchal JT, Gooley TA, Joachim Deeg H. " Allogeneic haematopoietic cell transplantation for myelofibrosis in 30 patients 60-78 years of age. " Br. J. Haematol.. 2011 Apr ; 153 (1) : 76-82.
Pubmed PMID: 21323890.
Savoldo B, Ramos CA, Liu E, Mims MP, Keating MJ, Carrum G, Kamble RT, Bollard CM, Gee AP, Mei Z, Liu H, Grilley B, Rooney CM, Heslop HE, Brenner MK, Dotti G. " CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. " J. Clin. Invest.. 2011 May 2; 121 (5) : 1822-6.
Pubmed PMID: 21540550.
Popat U, Carrum G, May R, Lamba R, Krance RA, Heslop HE, Brenner MK. " CD52 and CD45 monoclonal antibodies for reduced intensity hemopoietic stem cell transplantation from HLA matched and one antigen mismatched unrelated donors. " Bone Marrow Transplant.. 2005 Jun ; 35 (12) : 1127-32.
Pubmed PMID: 15834432.
Kamble RT, Chang CC, Sanchez S, Carrum G. " Central nervous system graft-versus-host disease: report of two cases and literature review. " Bone Marrow Transplant.. 2007 Jan ; 39 (1) : 49-52.
Pubmed PMID: 17099715.
Sun W, Popat U, Hutton G, Zang YC, Krance R, Carrum G, Land GA, Heslop H, Brenner M, Zhang JZ. " Characteristics of T-cell receptor repertoire and myelin-reactive T cells reconstituted from autologous haematopoietic stem-cell grafts in multiple sclerosis. " Brain. 2004 May ; 127 : 996-1008.
Pubmed PMID: 14985264.
Kennedy-Nasser AA, Leung KS, Mahajan A, Weiss HL, Arce JA, Gottschalk S, Carrum G, Khan SP, Heslop HE, Brenner MK, Bollard CM, Krance RA. " Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia. " Biol. Blood Marrow Transplant.. 2006 Dec ; 12 (12) : 1277-84.
Pubmed PMID: 17162209.
Okur FV, Yvon E, Biagi E, Dotti G, Carrum G, Heslop H, Mims MP, Fratantoni JC, Peshwa MV, Li L, Brenner MK. " Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia. " Cytotherapy. 2011 Oct ; 13 (9) : 1128-39.
Pubmed PMID: 21745159.
Bollard CM, Gottschalk S, Leen AM, Weiss H, Straathof KC, Carrum G, Khalil M, Wu MF, Huls MH, Chang CC, Gresik MV, Gee AP, Brenner MK, Rooney CM, Heslop HE. " Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. " Blood. 2007 Oct 15; 110 (8) : 2838-45.
Pubmed PMID: 17609424.
Yavorkovsky LL, Carrum G, Bruce S, McCarthy PL. " Cutaneous sarcoidosis in a patient with Philadelphia-positive chronic myelogenous leukemia treated with interferon-alpha. " Am. J. Hematol.. 1998 May ; 58 (1) : 80-1.
Pubmed PMID: 9590155.
Kosarac O, Carrum G, Mody D, Takei H. " Cytologic findings in allogeneic and autologous bone marrow transplant patients with pulmonary symptoms: a 9-year follow-up study. " Acta Cytol.. ; 53 (5) : 565-70.
Pubmed PMID: 19798885.
Bollard CM, Aguilar L, Straathof KC, Gahn B, Huls MH, Rousseau A, Sixbey J, Gresik MV, Carrum G, Hudson M, Dilloo D, Gee A, Brenner MK, Rooney CM, Heslop HE. " Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease. " J. Exp. Med.. 2004 Dec 20; 200 (12) : 1623-33.
Pubmed PMID: 15611290.
Carrum G, Egan JM, Abernethy DR. " Diltiazem treatment impairs hepatic drug oxidation: studies of antipyrine. " Clin. Pharmacol. Ther.. 1986 Aug ; 40 (2) : 140-3.
Pubmed PMID: 3731677.
Popat U, Carrum G, Heslop HE. " Haemopoietic stem cell transplantation for acute lymphoblastic leukaemia. " Cancer Treat. Rev.. 2003 Feb ; 29 (1) : 41343.
Pubmed PMID: 12633575.
Appel SH, Engelhardt JI, Henkel JS, Siklos L, Beers DR, Yen AA, Simpson EP, Luo Y, Carrum G, Heslop HE, Brenner MK, Popat U. " Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. " Neurology. 2008 Oct 21; 71 (17) : 1326-34.
Pubmed PMID: 18936424.
Vu T, Carrum G, Hutton G, Heslop HE, Brenner MK, Kamble R. " Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation. " Bone Marrow Transplant.. 2007 Jun ; 39 (11) : 705-9.
Pubmed PMID: 17401392.
Kamble RT, Bollard C, Demmler G, LaSala PR, Carrum G. " Human metapneumovirus infection in a hematopoietic transplant recipient. " Bone Marrow Transplant.. 2007 Oct ; 40 (7) : 699-700.
Pubmed PMID: 17660843.
Rousseau RF, Biagi E, Dutour A, Yvon ES, Brown MP, Lin T, Mei Z, Grilley B, Popek E, Heslop HE, Gee AP, Krance RA, Popat U, Carrum G, Margolin JF, Brenner MK. " Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation. " Blood. 2006 Feb 15; 107 (4) : 1332-41.
Pubmed PMID: 16249392.
Carrum G, Abernethy DR, Sadhukhan M, Wright CE. " Minoxidil analysis in human plasma using high-performance liquid chromatography with electrochemical detection. Application to pharmacokinetic studies. " J. Chromatogr.. 1986 Aug 22; 381 (1) : 127-35.
Pubmed PMID: 3771710.
Leen AM, Myers GD, Sili U, Huls MH, Weiss H, Leung KS, Carrum G, Krance RA, Chang CC, Molldrem JJ, Gee AP, Brenner MK, Heslop HE, Rooney CM, Bollard CM. " Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. " Nat. Med.. 2006 Oct ; 12 (10) : 1160-6.
Pubmed PMID: 16998485.
Lonial S, Williams L, Carrum G, Ostrowski M, McCarthy P. " Neosartorya fischeri: an invasive fungal pathogen in an allogeneic bone marrow transplant patient. " Bone Marrow Transplant.. 1997 Apr ; 19 (7) : 753-5.
Pubmed PMID: 9156256.
Shafer JA, Heslop HE, Brenner MK, Carrum G, Wu MF, Liu H, Ahmed N, Gottschalk S, Kamble R, Leung KS, Myers GD, Bollard CM, Krance RA. " Outcome of hematopoietic stem cell transplant as salvage therapy for Hodgkin's lymphoma in adolescents and young adults at a single institution. " Leuk. Lymphoma. 2010 Apr ; 51 (4) : 664-70.
Pubmed PMID: 20367182.
Popat U, Heslop HE, Durett A, May R, Krance RA, Brenner MK, Carrum G. " Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation (RISCT) using antilymphocyte antibodies in patients with high-risk acute myeloid leukemia (AML). " Bone Marrow Transplant.. 2006 Mar ; 37 (6) : 547-52.
Pubmed PMID: 16462757.
al-Awami Y, Sears DA, Carrum G, Udden MM, Alter BP, Conlon CL. " Pure red cell aplasia associated with hepatitis C infection. " Am. J. Med. Sci.. 1997 Aug ; 314 (2) : 113-7.
Pubmed PMID: 9258213.
Nasta SD, Carrum GM, Shahab I, Hanania NA, Udden MM. " Regression of a plasmablastic lymphoma in a patient with HIV on highly active antiretroviral therapy. " Leuk. Lymphoma. 2002 Feb ; 43 (2) : 423-6.
Pubmed PMID: 11999580.
Biagi E, Rousseau R, Yvon E, Schwartz M, Dotti G, Foster A, Havlik-Cooper D, Grilley B, Gee A, Baker K, Carrum G, Rice L, Andreeff M, Popat U, Brenner M. " Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia. " Clin. Cancer Res.. 2005 Oct 1; 11 (19) : 6916-23.
Pubmed PMID: 16203783.
Kamble R, Oholendt M, Carrum G. " Rituximab responsive refractory acute graft-versus-host disease. " Biol. Blood Marrow Transplant.. 2006 Nov ; 12 (11) : 1201-2.
Pubmed PMID: 17085314.
Foster AE, Okur FV, Biagi E, Lu A, Dotti G, Yvon E, Savoldo B, Carrum G, Andreeff M, Goodell MA, Heslop HE, Brenner MK. " Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression. " Mol. Cancer. 2009 ; 8 : 106.
Pubmed PMID: 19922650.
Foster AE, Okur FV, Biagi E, Lu A, Dotti G, Yvon E, Savoldo B, Carrum G, Goodell MA, Heslop HE, Brenner MK. " Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine. " Leukemia. 2010 Mar ; 24 (3) : 563-72.
Pubmed PMID: 20072155.
Abernethy DR, Egan JM, Dickinson TH, Carrum G. " Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans. " J. Pharmacol. Exp. Ther.. 1988 Mar ; 244 (3) : 994-9.
Pubmed PMID: 3252045.
Kamble RT, Tin-U CK, Carrum G. " Successful mobilization and transplantation of filgrastim mobilized hematopoietic stem cells in sickle cell-hemoglobin C disease. " Bone Marrow Transplant.. 2006 Jun ; 37 (11) : 1065-6.
Pubmed PMID: 16708064.
Ahmed N, Leung KS, Rosenblatt H, Bollard CM, Gottschalk S, Myers GD, Carrum G, Heslop HE, Brenner MK, Krance RA. " Successful treatment of stem cell graft failure in pediatric patients using a submyeloablative regimen of campath-1H and fludarabine. " Biol. Blood Marrow Transplant.. 2008 Nov ; 14 (11) : 1298-304.
Pubmed PMID: 18940685.
El Fakih R, Obi GA, Scholoff A, Carrum G, Kamble RT. " Systemic effects of oral budesonide in hematopoietic transplant: implications of drug interaction with azoles. " Bone Marrow Transplant.. 2012 Oct ; 47 (10) : 1370-1.
Pubmed PMID: 22327133.
Ganguly S, Carrum G, Nizzi F, Heslop HE, Popat U. " Transfusion-related acute lung injury (TRALI) following allogeneic stem cell transplant for acute myeloid leukemia. " Am. J. Hematol.. 2004 Jan ; 75 (1) : 48-51.
Pubmed PMID: 14695632.
Kamble RT, Clark DA, Leong HN, Heslop HE, Brenner MK, Carrum G. " Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation. " Bone Marrow Transplant.. 2007 Sep ; 40 (6) : 563-6.
Pubmed PMID: 17637686.
Pasquini MC, Voltarelli J, Atkins HL, Hamerschlak N, Zhong X, Ahn KW, Sullivan KM, Carrum G, Andrey J, Bredeson CN, Cairo M, Gale RP, Hahn T, Storek J, Horowitz MM, McSweeney PA, Griffith LM, Muraro PA, Pavletic SZ, Nash RA. " Transplantation for autoimmune diseases in north and South America: a report of the center for international blood and marrow transplant research. " Biol. Blood Marrow Transplant.. 2012 Oct ; 18 (10) : 1471-8.
Pubmed PMID: 22705497.
Hsu B, May R, Carrum G, Krance R, Przepiorka D. " Use of antithymocyte globulin for treatment of steroid-refractory acute graft-versus-host disease: an international practice survey. " Bone Marrow Transplant.. 2001 Nov ; 28 (10) : 945-50.
Pubmed PMID: 11753549.