Positions
- Associate Professor
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Pathology and Immunology
Baylor College of Medicine
- Associate Professor
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Molecular & Cellular Biology
Baylor College of Medicine
- Faculty Member
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Cancer & Cell Biology Graduate Program and Development, Disease Models & Therapeutics Graduate Program
Baylor College of Medicine
- Faculty Senator
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Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Addresses
- One Baylor Plaza (Office)
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Office: BCM-T221
Houston, TX 77030-3411
United States
- One Baylor Plaza (Lab)
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Lab: BCM-T207
Houston, TX 77030-3411
United States
Education
- PhD from Institute of Biophysics, Chinese Academy of Sciences
- Beijing, China
- Postdoctoral Training at Baylor College of Medicine
- Houston, Texas United States
Honors & Awards
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2023
- Research Project Grant (R01)
- NCI/NIH, 2023
- Individual Investigator Research Award
- Cancer Prevention & Research Institute of Texas, 2020
- Breakthrough Award Funding Level 2
- DOD, Breast Cancer Research Program, 2017
- Collaborative Research Project with AHMMRF
- Adrienne Helis Malvin Medical Research Foundation, 2015
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2013
- Individual Investigator Research Award
- Cancer Prevention & Research Institute of Texas, 2013
- Idea Development Award
- DOD, Prostate Cancer Research Program, 2013
- New Investigator Award
- DOD, Prostate Cancer Research Program, 2009
- Concept Award
- DOD, Breast Cancer Research Program, 2009
- Exploration-Hypothesis Development Award
- DOD, Prostate Cancer Research Program, 2007
Professional Interests
- MAPK4 biology in human cancers
- Signaling Pathways Regulating Prostate Cancer
- Therapy-resistance of Human Cancers
- Mouse Models for Human Cancers
- Tumor Microenvironment
Professional Statement
Focusing on cancer research, educating researchers, making discoveries, and turning discoveries into effective therapies for cancer patients.Websites
Selected Publications
- Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F "MAPK4 overexpression promotes tumor progression via non-canonical activation of Akt/mTOR signaling." J Clin Invest. 2019;129(3):1015-29. Pubmed PMID: 30688659
- Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann M, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang F "MAPK4 Promotes Prostate Cancer by Concerted Activation of Androgen Receptor and AKT." J Clin Invest. 2021;131(4):e135465. Pubmed PMID: 33586682
- Cai Q, Zhou W, Wang W, Dong B, Han D, Shen T, Creighton CJ, Moore DD, Yang F "MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade." Sci Adv. 2021;7(46):eabi6439. Pubmed PMID: 34767444
- Shen T, Dong B, Meng Y, Moore DD, Yang F "A COP1-GATA2 axis suppresses AR signaling and prostate cancer." Proc Natl Acad Sci U S A. 2022;119(43):e2205350119. Pubmed PMID: 36251994
- Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang F. "MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade." Nat Commun. 2022;13(1):245. Pubmed PMID: 35017531
- Han D, Wang W, Jeon JH, Shen T, Huang X, Yi P, Dong B, Yang F "Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy." PLoS Biol. 2023;21(8):e3002227. Pubmed PMID: 37531320
Projects
- MAPK4 biology in human cancers
- MAPK4 is an atypical MAPK that was not well studied. MAPK4 biology in human diseases, including cancers, was largely unknown. We discovered that MAPK4 activates Akt/mTOR and several other key signal pathways to promote cancer initiation, progression, and therapy-resistance. We are now pioneering the research on MAPK4 biology in human cancers and are carrying out in-depth studies to reveal the molecular mechanisms underlying MAPK4 regulation of human cancers.
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