Diana Monsivais, Ph.D.
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Diana Monsivais, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Pathology and Immunology
Baylor College of Medicine
Addresses
- Baylor College of Medicine (Lab)
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One Baylor Plaza
S217A
Houston, TX 77030
United States
dmonsiva@bcm.edu
Education
- PhD from Northwestern University
- Chicago, Illinois United States
- Life Sciences/Molecular Biology
- MS from Chicago State University
- Chicago, Illinois United States
- Cell and Molecular Biology
- BS from University of Illinois at Urbana-Champaign
- Urbana-Champaign, Illinois United States
- Biological Sciences
Professional Statement
The endometrium, or inner lining of the uterus, is a truly unique tissue with a highly regenerative potential that is crucial for reproductive capacity and the overall health of women. Endometrial dysfunction can result in a myriad of defects that affect women's health including infertility, heavy menstrual bleeding, endometriosis, adenomyosis or cancer. The goal of my research is to improve the current treatments available to treat infertility by studying the signaling pathways that control endometrial receptivity during early pregnancy. Achieving optimal endometrial receptivity is an unmet need in the success of ART procedures, therefore my research in mouse models and primary human cells aims to uncover the biological pathways that control endometrial function during the time of embryo implantation. My group also uses 3D cultures to study endometrial cell regeneration and to develop therapies for endometriosis and endometrial cancer.Websites
Selected Publications
- Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM. "Uterine ALK3 is essential during the window of implantation.." PNAS. 2016 : Pubmed PMID: 26721398
- Monsivais D, Matzuk MM, Pangas SA. "The TGF-β Family in the Reproductive Tract.." Cold Spring Harb Perspect Biol .. 2017 : Pubmed PMID: 28193725
- Monsivais D, Clementi C, Peng J, Fullerton PT Jr, Prunskaite-Hyyryläinen R, Vainio SJ, Matzuk MM. "BMP7 Induces Uterine Receptivity and Blastocyst Attachment.." Endocrinology. 2017 April ; : Pubmed PMID: 28324064
- Monsivais D, Dyson MT, Yin P, Navarro A, Coon JS 5th, Pavone ME, Bulun SE. "Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation.." Fertility and Sterility. 2016 : Pubmed PMID: 26827666
- Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. "ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis.." Molecular Endocrinology. 2014 : Pubmed PMID: 24992181
- Monsivais D, Bray JD, Su E, Pavone ME, Dyson MT, Navarro A, Kakinuma T, Bulun SE. "Activated glucocorticoid and eicosanoid pathways in endometriosis.." Fertility and Sterility. 2012 July ; : Pubmed PMID: 22521153
- Peng J, Monsivais D, You R, Zhong H, Pangas SA, Matzuk MM. "Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development.." PNAS. 2015 : Pubmed PMID: 26305969
- Ma JJ, Monsivais D, Dyson MT, Coon JS, Malpani S, Ono M, Zhao H, Xin H, Pavone ME, Kim JJ, Chakravarti D, Bulun SE. "Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival.." Horm Cancer. 2013 : Pubmed PMID: 23943160
- Diana Monsivais, Jia Peng , Yibin Kang, Martin M Matzuk "Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma." PNAS. 2019 February ; : Pubmed PMID: 30655341
- Kriseman M, Monsivais D, Agno J, Masand RP, Creighton CJ, Matzuk MM. "Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer.." PNAS. 2019 : Pubmed PMID: 30651315
- Monsivais D., Nagashima T., Prunskaite-Hyyrylainen R, Nozawa K, Shimada K, Tang S, Hamor C, Agno JE, Chen F, Masand RP, Young SL, Creighton CJ, DeMayo FJ, Ikawa M, Lee S, Matzuk MM "Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis." Nature Communications. 2021 June 7; : Pubmed PMID: 34099644
- Monsivais D., Vasquez YM, Chen F, Zhng Y, Chandrasehekar DS, Faver JC, Masand RP, Scheurer ME, Varambally S, Matzuk MM, Creighton CJ "Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers." Oncogene. 2021 March ; : Pubmed PMID: 33627787
- Peng J, Fullerton PT Jr, Monsivais D, Clementi C, Su GH, Matzuk MM. "Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation.." Molecular Endocrinology. 2015 : Pubmed PMID: 26484579
Memberships
- Society for the Study of Reproduction
- Member
- Endocrine Society
Funding
- Postdoctoral Fellow Research Education and Career Horizon Institutional Research and Academic Career Development Award (REACH-IRACDA)
- Postdoctoral Enrichment Program Award Burroughs Wellcome Fund
- NIH LRP Award Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIH Supplement to Promote Diversity in Research Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIH K99/R00 Pathway to Independence Award ( Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Next Gen Pregnancy Initiative ( Burroughs Wellcome Fund
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