Diana Monsivais, Ph.D.

Associate Professor

Email

diana.monsivais@bcm.edu

Positions

Associate Professor: Baylor College of Medicine

Addresses

Baylor College of Medicine (Lab): One Baylor Plaza
S217A
Houston, TX, 77030
United States
dmonsiva@bcm.edu

Education

PhD from Northwestern University: Chicago, Illinois, United States; Life Sciences/Molecular Biology

MS from Chicago State University: Chicago, Illinois, United States; Cell and Molecular Biology

BS from University of Illinois at Urbana-Champaign: Urbana-Champaign, Illinois, United States; Biological Sciences

Professional Statement

The endometrium, or inner lining of the uterus, is a unique tissue with a highly regenerative potential that is crucial for the reproductive health of women. Our group studies the signaling pathways that underpin endometrial regeneration and are abnormal in women with infertility, endometriosis and endometrial cancer. Using genetic mouse models and 3D-endometrial organoid cultures, it is our goal to determine the growth factors that control endometrial cell renewal and differentiation. We also conduct collaborative projects with the Center for Drug Discovery at BCM which aim to develop novel therapies for the treatment of endometriosis and endometrial cancer.

Websites

VIICTR Publications List

MyNCBI Library

Monsivais Laboratory

Selected Publications

Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM.. " Uterine ALK3 is essential during the window of implantation. " PNAS. 2016 ;
Pubmed PMID: 26721398.
Monsivais D, Matzuk MM, Pangas SA.. " The TGF-β Family in the Reproductive Tract. " Cold Spring Harb Perspect Biol .. 2017 ;
Pubmed PMID: 28193725.
Monsivais D, Clementi C, Peng J, Fullerton PT Jr, Prunskaite-Hyyryläinen R, Vainio SJ, Matzuk MM.. " BMP7 Induces Uterine Receptivity and Blastocyst Attachment. " Endocrinology. 2017 Apr ;
Pubmed PMID: 28324064.
Monsivais D, Dyson MT, Yin P, Navarro A, Coon JS 5th, Pavone ME, Bulun SE.. " Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid-regulated kinase activation. " Fertility and Sterility. 2016 ;
Pubmed PMID: 26827666.
Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE.. " ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. " Molecular Endocrinology. 2014 ;
Pubmed PMID: 24992181.
Monsivais D, Bray JD, Su E, Pavone ME, Dyson MT, Navarro A, Kakinuma T, Bulun SE.. " Activated glucocorticoid and eicosanoid pathways in endometriosis. " Fertility and Sterility. 2012 Jul ;
Pubmed PMID: 22521153.
Peng J, Monsivais D, You R, Zhong H, Pangas SA, Matzuk MM.. " Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development. " PNAS. 2015 ;
Pubmed PMID: 26305969.
Ma JJ, Monsivais D, Dyson MT, Coon JS, Malpani S, Ono M, Zhao H, Xin H, Pavone ME, Kim JJ, Chakravarti D, Bulun SE.. " Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival. " Horm Cancer. 2013 ;
Pubmed PMID: 23943160.
Diana Monsivais, Jia Peng , Yibin Kang, Martin M Matzuk. " Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma " PNAS. 2019 Feb ;
Pubmed PMID: 30655341.
Kriseman M, Monsivais D, Agno J, Masand RP, Creighton CJ, Matzuk MM.. " Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer. " PNAS. 2019 ;
Pubmed PMID: 30651315.
Monsivais D., Nagashima T., Prunskaite-Hyyrylainen R, Nozawa K, Shimada K, Tang S, Hamor C, Agno JE, Chen F, Masand RP, Young SL, Creighton CJ, DeMayo FJ, Ikawa M, Lee S, Matzuk MM. " Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis " Nature Communications. 2021 Jun 7;
Pubmed PMID: 34099644.
Monsivais D., Vasquez YM, Chen F, Zhng Y, Chandrasehekar DS, Faver JC, Masand RP, Scheurer ME, Varambally S, Matzuk MM, Creighton CJ. " Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers " Oncogene. 2021 Mar ;
Pubmed PMID: 33627787.
Peng J, Fullerton PT Jr, Monsivais D, Clementi C, Su GH, Matzuk MM.. " Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation. " Molecular Endocrinology. 2015 ;
Pubmed PMID: 26484579.

Memberships

Society for the Study of Reproduction: Member

Endocrine Society

Funding

R01 HD105800: Eunice Kennedy Shriver National Institute of Child Health and Human Development

Next Gen Pregnancy Award: Burroughs Wellcome Fund

NIH K99/R00 Pathway to Independence Award: Eunice Kennedy Shriver National Institute of Child Health and Human Development

Postdoctoral Enrichment Program Award: Burroughs Wellcome Fund

NIH Supplement to Promote Diversity in Research: Eunice Kennedy Shriver National Institute of Child Health and Human Development

Postdoctoral Fellow: Research Education and Career Horizon Institutional Research and Academic Career Development Award (REACH-IRACDA)