Daniel Gustavo Rosen, M.D.

Associate Professor

Email

dgrosen@bcm.edu

Positions

Associate Professor: Pathology & Immunology
Pathology and Laboratory Medicine
Baylor College of Medicine
Houston, TX, US

Addresses

BCM-Cullen Building (Lab): Room: BCMC-286A
Houston, TX, 77030
United States

Education

Advanced Training from University Of Texas MD Anderson Cancer Center: 01/2011 - Houston, TX, United States

Advanced Training from Baylor College Of Medicine: 01/2010 - Houston, TX, United States

Advanced Training from University Of Texas MD Anderson Cancer Center: 01/2006 - Houston, TX, United States

M.D. from Facultad De Medicina, Universidad De Buenos Aires: 01/1993 - Buenos Aires, Argentina

Websites

VIICTR Publications List

Selected Publications

Zhang Z, Singh M, Davidson S, Rosen DG, Yang G, Liu J. " Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries. " Mod. Pathol.. 2007 Oct ; 20 (10) : 1078-84.
Pubmed PMID: 17673924.
Chang B, Liu G, Xue F, Rosen DG, Xiao L, Wang X, Liu J. " ALDH1 expression correlates with favorable prognosis in ovarian cancers. " Mod. Pathol.. 2009 Jun ; 22 (6) : 817-23.
Pubmed PMID: 19329942.
Yu Y, Luo R, Lu Z, Wei Feng W, Badgwell D, Issa JP, Rosen DG, Liu J, Bast RC. " Biochemistry and biology of ARHI (DIRAS3), an imprinted tumor suppressor gene whose expression is lost in ovarian and breast cancers. " Meth. Enzymol.. 2006 ; 407 : 455-68.
Pubmed PMID: 16757345.
Yang F, Guo X, Yang G, Rosen DG, Liu J. " AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma. " Mod. Pathol.. 2011 Jun ; 24 (6) : 836-45.
Pubmed PMID: 21441901.
Rosen D, Lewis AM, Mizote A, Thomas JM, Aley PK, Vasudevan SR, Parkesh R, Galione A, Izumi M, Ganesan A, Churchill GC. " Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. " J. Biol. Chem.. 2009 Dec 11; 284 (50) : 34930-4.
Pubmed PMID: 19826006.
Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP, Kango-Singh M, Lu KH, Warneke CL, Atkinson EN, Bedrosian I, Keyomarsi K, Kuo WL, Gray JW, Yin JC, Liu J, Halder G, Mills GB. " Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. " Proc. Natl. Acad. Sci. U.S.A.. 2005 Aug 30; 102 (35) : 12519-24.
Pubmed PMID: 16116079.
Zhang J, Guo X, Chang DY, Rosen DG, Mercado-Uribe I, Liu J. " CD133 expression associated with poor prognosis in ovarian cancer. " Mod. Pathol.. 2012 Mar ; 25 (3) : 456-64.
Pubmed PMID: 22080056.
Nudelman RJ, Rosen DG, Rouah E, Verstovsek G. " Cerebral sinus thrombosis: a fatal neurological complication of ulcerative colitis. " Patholog Res Int. 2010 ; 2010 : 132754.
Pubmed PMID: 21152173.
Parkesh R, Lewis AM, Aley PK, Arredouani A, Rossi S, Tavares R, Vasudevan SR, Rosen D, Galione A, Dowden J, Churchill GC. " Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells. " Cell Calcium. 2008 Jun ; 43 (6) : 531-8.
Pubmed PMID: 17935780.
Feng W, Shen L, Wen S, Rosen DG, Jelinek J, Hu X, Huan S, Huang M, Liu J, Sahin AA, Hunt KK, Bast RC, Shen Y, Issa JP, Yu Y. " Correlation between CpG methylation profiles and hormone receptor status in breast cancers. " Breast Cancer Res.. 2007 ; 9 (4) : R57.
Pubmed PMID: 17764565.
Ramanathan V, Suki WN, Rosen D, Truong LD. " Chronic allograft nephropathy and nephrotic range proteinuria. " Clin Transplant. 2005 Jun ; 19 (3) : 413-7.
Pubmed PMID: 15877807.
Rosen DG, Zhang Z, Shan W, Liu J. " Morphological and molecular basis of ovarian serous carcinoma. " J Biomed Res. 2010 Jul ; 24 (4) : 257-63.
Pubmed PMID: 23554638.
Shan W, Mercado-Uribe I, Zhang J, Rosen D, Zhang S, Wei J, Liu J. " Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications. " Cell Cycle. 2012 Jun 1; 11 (11) : 2107-13.
Pubmed PMID: 22592533.
Rosen DG, Yang G, Liu G, Mercado-Uribe I, Chang B, Xiao XS, Zheng J, Xue FX, Liu J. " Ovarian cancer: pathology, biology, and disease models. " Front. Biosci.. 2009 ; 14 : 2089-102.
Pubmed PMID: 19273186.
Yakupoglu U, Baranowska-Daca E, Rosen D, Barrios R, Suki WN, Truong LD. " Post-transplant nephrotic syndrome: A comprehensive clinicopathologic study. " Kidney Int.. 2004 Jun ; 65 (6) : 2360-70.
Pubmed PMID: 15149349.
Rosen DG, Lopez AE, Anzalone ML, Wolf DA, Derrick SM, Florez LF, Gonsoulin ML, Hines MO, Mitchell RA, Phatak DR, Haden-Pinneri K, Sanchez LA. " Postmortem findings in eight cases of influenza A/H1N1. " Mod. Pathol.. 2010 Nov ; 23 (11) : 1449-57.
Pubmed PMID: 20802471.
Rosen DG, Wang L, Atkinson JN, Yu Y, Lu KH, Diamandis EP, Hellstrom I, Mok SC, Liu J, Bast RC. " Potential markers that complement expression of CA125 in epithelial ovarian cancer. " Gynecol. Oncol.. 2005 Nov ; 99 (2) : 267-77.
Pubmed PMID: 16061277.
Lu KH, Patterson AP, Wang L, Marquez RT, Atkinson EN, Baggerly KA, Ramoth LR, Rosen DG, Liu J, Hellstrom I, Smith D, Hartmann L, Fishman D, Berchuck A, Schmandt R, Whitaker R, Gershenson DM, Mills GB, Bast RC. " Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. " Clin. Cancer Res.. 2004 May 15; 10 (10) : 3291-300.
Pubmed PMID: 15161682.
Feng W, Xiao J, Zhang Z, Rosen DG, Brown RE, Liu J, Duan X. " Senescence and apoptosis in carcinogenesis of cervical squamous carcinoma. " Mod. Pathol.. 2007 Sep ; 20 (9) : 961-6.
Pubmed PMID: 17632454.
Rosen DG, Yang G, Cai KQ, Bast RC, Gershenson DM, Silva EG, Liu J. " Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. " Clin. Cancer Res.. 2005 Jan 15; 11 (2) : 632-7.
Pubmed PMID: 15701850.
Rosen D, Bloor-Young D, Squires J, Parkesh R, Waters G, Vasudevan SR, Lewis AM, Churchill GC. " Synthesis and use of cell-permeant cyclic ADP-ribose. " Biochem. Biophys. Res. Commun.. 2012 Feb 10; 418 (2) : 353-8.
Pubmed PMID: 22274607.
Yang G, Xiao X, Rosen DG, Cheng X, Wu X, Chang B, Liu G, Xue F, Mercado-Uribe I, Chiao P, Du X, Liu J. " The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer. " Clin. Cancer Res.. 2011 Apr 15; 17 (8) : 2181-94.
Pubmed PMID: 21339307.
Perry KD, Reynolds C, Rosen DG, Edgerton ME, T Albarracin C, Gilcrease MZ, Sahin AA, Abraham SC, Wu Y. " Metastatic neuroendocrine tumour in the breast: a potential mimic of in-situ and invasive mammary carcinoma. " Histopathology. 2011 Oct ; 59 (4) : 619-30.
Pubmed PMID: 22014043.
Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P. " Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. " J. Biol. Chem.. 2005 Nov 25; 280 (47) : 39485-92.
Pubmed PMID: 16179351.
Yang G, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, Bast RC, Zhou C, Liu J. " Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. " Carcinogenesis. 2007 Jan ; 28 (1) : 174-82.
Pubmed PMID: 16829690.
Wang H, Rosen DG, Wang H, Fuller GN, Zhang W, Liu J. " Insulin-like growth factor-binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types. " Mod. Pathol.. 2006 Sep ; 19 (9) : 1149-56.
Pubmed PMID: 16729015.
Zheng J, Mercado-Uribe I, Rosen DG, Chang B, Liu P, Yang G, Malpica A, Noara H, Auersperg N, Mills GB, Bast RC, Liu J. " Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment. " Cell Cycle. 2010 Jan 1; 9 (1) : 140-6.
Pubmed PMID: 20016289.
Rosen DG, Cai KQ, Luthra R, Liu J. " Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma. " Mod. Pathol.. 2006 Nov ; 19 (11) : 1414-20.
Pubmed PMID: 16941012.
Naylor E, Arredouani A, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A, Churchill GC. " Identification of a chemical probe for NAADP by virtual screening. " Nat. Chem. Biol.. 2009 Apr ; 5 (4) : 220-6.
Pubmed PMID: 19234453.
Rosen DG, Laucirica R, Verstovsek G. " Fine needle aspiration of male breast lesions. " Acta Cytol.. ; 53 (4) : 369-74.
Pubmed PMID: 19697719.
Rosen DG, Zhang Z, Chang B, Wang X, Lin E, Liu J. " Low membranous expression of beta-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary. " Mod. Pathol.. 2010 Jan ; 23 (1) : 113-22.
Pubmed PMID: 19820688.
Rosen DG, Wang L, Jain AN, Lu KH, Luo RZ, Yu Y, Liu J, Bast RC. " Expression of the tumor suppressor gene ARHI in epithelial ovarian cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival. " Clin. Cancer Res.. 2004 Oct 1; 10 (19) : 6559-66.
Pubmed PMID: 15475444.
Lee P, Rosen DG, Zhu C, Silva EG, Liu J. " Expression of progesterone receptor is a favorable prognostic marker in ovarian cancer. " Gynecol. Oncol.. 2005 Mar ; 96 (3) : 671-7.
Pubmed PMID: 15721410.
Zhang Z, Rosen DG, Yao JL, Huang J, Liu J. " Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression. " Mod. Pathol.. 2006 Oct ; 19 (10) : 1339-43.
Pubmed PMID: 16799475.
Rosen D, Herrington B, Bhargava P, Laucirica R, Verstovsek G. " Correlation of tissue biopsy and fine needle aspiration cytology with positron emission tomography results. " Patholog Res Int. 2011 ; 2011 : 323051.
Pubmed PMID: 21559200.
Yang G, Rosen DG, Liu G, Yang F, Guo X, Xiao X, Xue F, Mercado-Uribe I, Huang J, Lin SH, Mills GB, Liu J. " CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. " Clin. Cancer Res.. 2010 Aug 1; 16 (15) : 3875-86.
Pubmed PMID: 20505188.
Rosen DG, Yang G, Deavers MT, Malpica A, Kavanagh JJ, Mills GB, Liu J. " Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. " Cancer. 2006 May 1; 106 (9) : 1925-32.
Pubmed PMID: 16568440.
Yang G, Rosen DG, Colacino JA, Mercado-Uribe I, Liu J. " Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells. " Oncogene. 2007 Mar 1; 26 (10) : 1492-8.
Pubmed PMID: 16953228.
Wang-Johanning F, Liu J, Rycaj K, Huang M, Tsai K, Rosen DG, Chen DT, Lu DW, Barnhart KF, Johanning GL. " Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer. " Int. J. Cancer. 2007 Jan 1; 120 (1) : 81-90.
Pubmed PMID: 17013901.
Yang G, Rosen DG, Zhang Z, Bast RC, Mills GB, Colacino JA, Mercado-Uribe I, Liu J. " The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. " Proc. Natl. Acad. Sci. U.S.A.. 2006 Oct 31; 103 (44) : 16472-7.
Pubmed PMID: 17060621.
Rosen DG, Mercado-Uribe I, Yang G, Bast RC, Amin HM, Lai R, Liu J. " The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. " Cancer. 2006 Dec 1; 107 (11) : 2730-40.
Pubmed PMID: 17063503.
Lu Z, Luo RZ, Peng H, Rosen DG, Atkinson EN, Warneke C, Huang M, Nishmoto A, Liu J, Liao WS, Yu Y, Bast RC. " Transcriptional and posttranscriptional down-regulation of the imprinted tumor suppressor gene ARHI (DRAS3) in ovarian cancer. " Clin. Cancer Res.. 2006 Apr 15; 12 (8) : 2404-13.
Pubmed PMID: 16638845.
Young TW, Rosen DG, Mei FC, Li N, Liu J, Wang XF, Cheng X. " Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. " Clin. Cancer Res.. 2007 Jul 1; 13 (13) : 3848-54.
Pubmed PMID: 17606716.
Young TW, Mei FC, Rosen DG, Yang G, Li N, Liu J, Cheng X. " Up-regulation of tumor susceptibility gene 101 protein in ovarian carcinomas revealed by proteomics analyses. " Mol. Cell Proteomics. 2007 Feb ; 6 (2) : 294-304.
Pubmed PMID: 17110434.
Rosen DG, Yang G, Bast RC, Liu J. " Use of Ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer. " Meth. Enzymol.. 2006 ; 407 : 660-76.
Pubmed PMID: 16757360.
Rosen DG, Huang X, Deavers MT, Malpica A, Silva EG, Liu J. " Validation of tissue microarray technology in ovarian carcinoma. " Mod. Pathol.. 2004 Jul ; 17 (7) : 790-7.
Pubmed PMID: 15073602.
Nunez MI, Rosen DG, Ludes-Meyers JH, Abba MC, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB, Aldaz CM. " WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. " BMC Cancer. 2005 ; 5 : 64.
Pubmed PMID: 15982416.

Languages

Spanish