sandweis

Alexander Sandweiss, MD, PhD

Picture

Alexander Sandweiss, MD, PhD

Basic Neuroscience Research Pathway

Email

alexander.sandweiss@bcm.edu

Positions

Basic Neuroscience Research Pathway: Child Neurology
Baylor College of Medicine
Houston, TX US

Education

MD from University of Arizona: 05/2018 - Tucson, Arizona

PhD from University of Arizona: 06/2016 - Arizona, Tucson; Pharmacology/Neuroscience

BS from University of Arizona: 05/2011 - Tucson; Physiology, Music

Honors & Awards

Chief Resident, 2021-2022: Baylor College of Medicine

Professional Statement

Alex is originally from Phoenix, Arizona. He moved two hours south to Tucson, Arizona where he lived for 11 years while attending The University of Arizona. He studied physiology and music in undergrad, then began medical school and his PhD in pharmacology at The University of Arizona COM. For his PhD dissertation, Alex studied the role of the neuropeptide substance p in the neural circuitry of opioid reward, with the goal of developing a novel analgesic that lacks the potential for abuse.
Now in child neurology residency, his focus lies in training as a pediatric neurologist with a special research interest in nervous system autoimmune diseases such as encephalitis.

Videos

Baylor College of Medicine Child Neurology Residency Program

Child Neurology Residency video made and music scored by Alex Sandweiss

Selected Publications

Alexander J. Sandweiss, Vicky Brandt, Huda Y. Zoghbi "Advances in understanding Rett syndrome and MECP2 duplication syndrome: prospects for future therapies.." The Lancet Neurology. 2020 Aug 1;19(8):689-698.
Alexander J. Sandweiss, Mary I. McIntosh, Aubin Moutal, Rachel Davidson-Knapp, Jackie Hu, Aswini K. Giri, Takashi Yamamoto, Victor J. Hruby, Rajesh Khanna, Tally M. Largent-Milnes, Todd W. Vanderah "Genetic and pharmacological antagonism of NK 1 receptor prevents opiate abuse potential." Molecular Psychiatry. 2018 Aug;23(8):1745-1755. Pubmed PMID: 28485408
Alexander J. Sandweiss, Karissa E. Cottier, Mary I. McIntosh, Gregory Dussor, Thomas Davis, Todd W. Vanderah, Tally Largent-Milnes "17-β-estradiol induces cortical spreading depression and pain behavior in alert female rats." Oncotarget. 2017 Dec 9;8(69):11409-114122. Pubmed PMID: 29371973
Alexander J. Sandweiss, Asad Azim, Kareem Ibraheem, Tally M. Largent-Milnes, Peter Rhee, Todd W. Vanderah, Bellal Joseph "Remote ischemic conditioning preserves cognition and motor coordination in a mouse model of traumatic brain injury." Journal of Trauma and Acute Care Surgery. 2017 Dec;83(6):1074-1081. Pubmed PMID: 28609381

Alexander J Sandweiss, Todd W Vanderah "The Pharmacology of Neurokinin Receptors in Addiction: Prospects for Therapy." Substance Abuse and Rehabilitation. 2015 Sep 7;7(6):93-102. Pubmed PMID: 26379454
Alexander J. Sandweiss, Mohammad Y Bader, Shalinkumar Patel, Ranjit I Kylat "A truncating variant of CHRNG as a cause of non-lethal Escobar Syndrome, a multiple ptrerygium syndrome subtype." Journal of Pediatric Genetics. 2020 Aug 26;
Bruhns RP, Sulaiman MI, Gaub M, Bae EH, Davidson Knapp RB, Larson AR, Smith A, Coleman DL, Staatz WD, Sandweiss AJ, Joseph B, Hay M, Largent-Milnes TM, Vanderah TW "Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury." Frontiers in Behavioral Neuroscience. 2022;16(903980) Pubmed PMID: 35990729
David Farrier, Alexander J. Sandweiss, Brittnie Bartlett, Farida Abid "Case report: potential role of growth hormone in a pediatric transient ischemic attack." Journal of Pediatric Neurology. 2020 Aug;
Alexander J. Sandweiss, Christopher Morrison, Anne Spichler, John Rozich "A case report of clonidine induced syncope: a review of central actions of an old cardiovascular drug." 2018 Feb 13;19(1):6.
Pouran Malekzadeh, Jackie Hu, Alexander J. Sandweiss, Nina Ameli, Tally M. Largent-Milnes, Todd W. Vanderah, Farshad Shirazi "Effect of centruroides antivenom on reversal of methamphetamine induced hyperkinesis and hyperthermia in rats." The Journal of Pharmaceutics and Pharmacology. 2017 Apr;5(1):1-5. Pubmed PMID: 29354652
Ruben S. Vardanyan, James P. Cain, Sahgar Mowlazadeh Haghighi, Vlad K. Kumirov, Mary I. McIntosh, Alexander J. Sandweiss, Frank Porreca, Victor J. Hruby "Synthesis and investigation of mixed μ- and δ-opioid agonists as possible bivalent ligands for treatment of pain." Journal of Heterocyclic Chemistry. 2017 Mar 1;54(2):1228-1235. Pubmed PMID: 28819330
Cyf N. Ramos-Colon, Yeon Sun Lee, Michael Remesic, Sara M. Hall, Justin LaVigne, Peg Davis, Alexander J. Sandweiss, Mary I. McIntosh, Jessica Hanson, Tally M. Largent-Milnes, Todd W. Vanderah, John Streicher, Frank Porreca, Victor J. Hruby "Structure Activity Relationships of [des-Arg7]- Dynorphin A Analogues at the Kappa Opioid Receptor." Journal of Medicinal Chemistry. 2016 Nov 23;59(22):10291-10298. Pubmed PMID: 27797517
Yeon Sun Lee, Dhanasekaran Muthu, Sara M. Hall, Cyf Ramos-Colon, David Rankin, Jackie Hu, Alexander J. Sandweiss, Milena De Felice, Jennifer Yanhua Xie, Todd W. Vanderah, Frank Porreca, Josephine Lai, and Victor J. Hruby "Discovery of Amphipathic Dynorphin A Analogues to Inhibit the Neuroexcitatory Effects of Dynorphin A through Bradykinin Receptors in the Spinal Cord." Journal of the American Chemical Society. 2014 May 7;136(18):6608-6616. Pubmed PMID: 24742335
Alexander T. Podolsky, Alexander Sandweiss, Jackie Hu, Edward J. Bilsky, Jim P. Cain, Vlad K. Kumirov, Yeon Sun Lee, Victor J. Hruby, Ruben S. Vardanyan, Todd W. Vanderah "Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain." Life Sciences. 2013 Dec 18;93(25):1010-1016. Pubmed PMID: 24084045