Alexander Sandweiss, MD, PhD
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Alexander Sandweiss, MD, PhD
Assistant Professor
Positions
- Assistant Professor
-
Pediatrics
Pediatric Neurology and Developmental Neuroscience
Baylor College of Medicine
Houston, Texas United States
Education
- Residency at Baylor College of Medicine
- 06/2023 - Houston, Texas United States
- Child Neurology
- MD from University of Arizona
- 05/2018 - Tucson, Arizona
- PhD from University of Arizona
- 06/2016 - Arizona, Tucson
- Pharmacology/Neuroscience
- BS from University of Arizona
- 05/2011 - Tucson, Arizona
- Physiology, Music
- Fellowship at Baylor College of Medicine
- 06/2024 - Houston, Texas United States
- Pediatric Neuroimmunology
Honors & Awards
- Chief Resident, 2021-2022
- Baylor College of Medicine
Professional Statement
Alex, originally from Phoenix, Arizona, relocated two hours south to Tucson, Arizona, where he resided for 11 years while pursuing his education at The University of Arizona. He studied physiology and music in undergrad, then began medical school and his PhD in pharmacology at The University of Arizona COM. For his PhD dissertation, Alex studied the role of the neuropeptide substance p in the neural circuitry of opioid reward, with the goal of developing a novel analgesic that lacks the potential for abuse.Upon completion of pediatric neurology residency at Baylor College of Medicine and Texas Children's Hospital, he began pediatric neuroimmunology fellowship, during which Alex's primary focus revolved around his research interest in autoimmune diseases affecting the nervous system, with a specific emphasis on encephalitis.
He is now an Assistant Professor at Baylor College of Medicine and Texas Children's Hospital where he runs his basic-science lab studying autoimmune neurological disorders such as encephalitis and demyelinating diseases.
Selected Publications
- Alexander J. Sandweiss, Vicky Brandt, Huda Y. Zoghbi "Advances in understanding Rett syndrome and MECP2 duplication syndrome: prospects for future therapies.." The Lancet Neurology. 2020 Aug 1;19(8):689-698. Pubmed PMID: 32702338
- Alexander J Sandweiss, Varun Kannan, Nilesh K Desai, Stephen F Kralik, Eyal Muscal, Kristen S Fisher "Arterial Spin Labeling Changes Parallel Asymmetric Perisylvian and Perirolandic Symptoms in 3 Pediatric Cases of Anti-NMDAR Encephalitis." Neur: Neuroimmunol & Neuroinflamm. 2023 Apr;10(4) Pubmed PMID: 37094999
- Alexander J Sandweiss, Jonathan Rosen, Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Madhuri Chilakapati, Rod Foroozan, Jonathan M Yarimi "MOGAD optic neuritis after mild head/orbital trauma in six children." J Neuroimmunol. 2025 Jul;15(404) Pubmed PMID: 40187047
- Alexander J Sandweiss, Timothy A Erickson, Yike Jiang, Varun Kannan, Jonathan M Yarimi, Jesse M Levine, Kristen Fisher, Eyal Muscal, Gail Demmler-Harrison, Kristy O Murray, Shannon E Ronca "Infectious profiles in pediatric anti-N-methyl-d-aspartate receptor encephalitis." J Neuroimmunology. 2023 Jun; Pubmed PMID: 37364517
- Alexander J. Sandweiss, Mary I. McIntosh, Aubin Moutal, Rachel Davidson-Knapp, Jackie Hu, Aswini K. Giri, Takashi Yamamoto, Victor J. Hruby, Rajesh Khanna, Tally M. Largent-Milnes, Todd W. Vanderah "Genetic and pharmacological antagonism of NK 1 receptor prevents opiate abuse potential." Molecular Psychiatry. 2018 Aug;23(8):1745-1755. Pubmed PMID: 28485408
- Alexander J. Sandweiss, Asad Azim, Kareem Ibraheem, Tally M. Largent-Milnes, Peter Rhee, Todd W. Vanderah, Bellal Joseph "Remote ischemic conditioning preserves cognition and motor coordination in a mouse model of traumatic brain injury." Journal of Trauma and Acute Care Surgery. 2017 Dec;83(6):1074-1081. Pubmed PMID: 28609381
- Alexander J Sandweiss, Todd W Vanderah "The Pharmacology of Neurokinin Receptors in Addiction: Prospects for Therapy." Substance Abuse and Rehabilitation. 2015 Sep 7;7(6):93-102. Pubmed PMID: 26379454
- Varun Kannan, Alexander J Sandweiss, Timothy A Erickson, Jonathan M Yarimi, Alexander Ankar, Victoria A Hardwick, Nikita M Shukla, Timothy E Lotze, Sarah R Risen, James J Riviello, Yi-Chen Lai, Karen K Moeller, Kristen Fisher "Fulminant anti-MOG-associated cerebral cortical encephalitis: case series of a severe pediatric MOGAD phenotype." Pediatric Neurology. 2023;In Press
- Gombolay G, Brenton JN, Yang JH, Stredny CM, Kammeyer R, Fisher KS, Sandweiss AJ,... "Isolated Psychiatric Symptoms in Children With Anti-N-Methyl-d Aspartate Receptor Encephalitis." Pediatr Neurol. 2024 Oct;(159):12-15. Pubmed PMID: 39094249
Memberships
- American Academy of Neurology
- Child Neurology Society
- American Academy of Pediatrics
- Texas Neurological Society
- Texas Pediatrics Society
- American Physiological Society
Funding
- Assessing the burden of post-HSV meningoencephalitis induced NMDAR encephalitis in children
- ( 08/01/2023 - 07/31/2024 ) Grant funding from Texas Neurological Society
- Exome sequencing for the discovery of genetic determinants of pediatric anti-NMDAR encephalitis
- ( 07/01/2022 - 06/30/2024 ) Grant funding from Thrasher Research Fund
- Underpinnings of racial and ethnic diversity in pediatric autoimmune encephalitis
- ( 09/01/2022 - 08/31/2023 ) Grant funding from Alpha Omega Alpha
- Resident Research Award
- ( 01/01/2023 - 12/31/2023 ) Grant funding from American Academy of Neurology
- Evaluation of novel therapies for autoimmune encephalitis
- ( 01/01/2023 - 12/31/2023 ) Grant funding from Mike Hogg Fund
- Chao Physician Scientist Award
- ( 07/01/2025 - 06/30/2026 ) Grant funding from Baylor College of Medicine
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