The "neglected tropical diseases" and "neglected infections of poverty" are the most common infections of the world's poorest people; together they trap people in poverty through their adverse impact on child development, pregnancy outcome and worker productivity.
A New Generation of NTD Control Tools
The National School of Tropical Medicine conducts a comprehensive research and development program for producing a new generation of drugs, diagnostics and vaccines for the Neglected Tropical Diseases (NTDs) and Neglected Infections of Poverty (NIoPs), as well as fundamental and applied research against these diseases.
In the area of NTD vaccine development, Texas Children's Hospital in partnership with the National School of Tropical Medicine has established the Sabin Vaccine Institute & Texas Children's Hospital Center for Vaccine Development.
Over the last 10 years the Sabin Vaccine Institute Product Development Partnership has led the development of new vaccines to combat NTDs. Through the activities of the Sabin Vaccine Institute PDP, a new human hookworm vaccine is in phase 1 clinical trials, while a schistosomiasis vaccine has undergone clinical good manufacturing practices (cGMP) and is awaiting regulatory approvals to initiate clinical testing. Vaccines against leishmaniasis, Chagas disease, and other soil-transmitted helminths are in development.