The "neglected tropical diseases" and "neglected infections of poverty" are the most common infections of the world's poorest people; together they trap people in poverty through their adverse impact on child development, pregnancy outcome and worker productivity.
For more information see What are Neglected Tropical Diseases and Neglected Infections of Poverty?
A New Generation of NTD Control Tools
The National School of Tropical Medicine conducts a comprehensive research and development program for producing a new generation of drugs, diagnostics and vaccines for the Neglected Tropical Diseases (NTDs) and Neglected Infections of Poverty (NIoPs), as well as fundamental and applied research against these diseases.
In the area of NTD vaccine development, Texas Children's Hospital in partnership with the National School of Tropical Medicine has brought into the Texas Medical Center community the renowned product development partnership of the Sabin Vaccine Institute, which has long been at the forefront of research and development, access and advocacy for these infectious, debilitating and disabling diseases worldwide.
Over the last 10 years the Sabin Vaccine Institute Product Development Partnership has led the development of new vaccines to combat NTDs such as hookworm infections and schistosomiasis. Through the activities of the Sabin Vaccine Institute PDP, a new human hookworm vaccine is in phase 1 clinical trials in Minas Gerais State, Brazil, while a schistosomiasis vaccine has undergone clinical good manufacturing practices (cGMP) and is awaiting regulatory approvals to initiate clinical testing . A new Chagas disease vaccine is at an earlier stage of preclinical development, with plans for manufacture and testing in Mexico
Collaborators in Vaccine Development
The establishment of the Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development located in the Ralph D. Feigin Research Center of Texas Children's Hospital brings together a core of scientists skilled in vaccine development. Sabin and the Center for Vaccine Development have established strong ties with the already formidable research family within the Texas Medical Center. View our collaborators.
The major developments that provide strong competencies for the NSTM include:
- Access to core scientists conducting research on NTDs and NIoPs with papers appearing in the world's highest impact journals
- Establishment of a complex and multidisciplinary research portfolio supported both by federal and non-federal agencies
- Creation of an experienced program and research management group able to support, advance and monitor complex research initiatives
- Establishing active research, biotechnology and educational collaborations with other academic and non-profit entities and institutions globally