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Department of Physical Medicine & Rehabilitation

Houston, Texas

A physician explains an X-ray image.
Department of Physical Medicine and Rehabilitation
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M. David Mansouri, Ph.D.

Assistant Professor

Education:

Ph.D., Baylor College of Medicine, Houston, Texas

M.S., Johns Hopkins University, Baltimore, Maryland

B.S. in biophysics & biochemistry, University of Houston, Houston, Texas

Research interest: Device-related infections, bioengineering and modification of implantable medical devices, antibiofilm strategies, and small-molecule antimicrobials

I have a long-standing interest in the pathogenesis, prevention, and treatment of device-associated infections with a concentration in the development of novel means to avert these infections, which remain a medical challenge and can lead to excessive morbidity, undue mortality, and increased healthcare costs.

Selected Publications:

Mansouri MD, Hull RA, Stager CE, Cadle RM, Darouiche RO.In vitro activity and durability of a combination of an antibiofilm and an antibiotic against vascular catheter colonization. Antimicrob Agents Chemother. 2013; 57(1):621-625.

Mansouri MD, Opperman TJ, Williams JD, Stager C, Darouiche RO.In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization. Antimicrob Agents Chemother. 2012; 56(4):2201-2204.

Mansouri MD, Cadle RM, Agbahiwe SO, Musher DM. Impact of an antibiotic restriction program on antibiotic utilization in the treatment of community-acquired pneumonia in a Veterans Affairs Medical Center. Infection. 2011; 39(1):53-58.

Mansouri MD, Awan L, Darouiche RO. In vitro efficacy of antimicrobial-treated drainage catheters in preventing bacterial colonization in biological fluids. Infect Control Hosp Epidemiol. 2011; 32(7):731-732.

Mansouri MD, Ramanathan V, Al-Sharif AH, Darouiche RO. Efficacy of trypsin in enhancing assessment of bacterial colonisation of vascular catheters. J Hosp Infect. 2010; 76(4):328-331.

Mansouri MD, Boone TB, Darouiche RO. Comparative assessment of antimicrobial activities of antibiotic-treated penile prostheses. Eur Urol. 2009; 56(6):1039-1045.

Viola GM, Mansouri MD, Nasir N Jr, Darouiche RO. Incubation alone is adequate as a culturing technique for cardiac rhythm management devices. J Clin Microbiol. 2009; 47(12):4168-4170.

Darouiche RO, Mansouri MD, Gawande PV, Madhyastha S. Antimicrobial and antibiofilm efficacy of triclosan and DispersinB combination. J Antimicrob Chemother. 2009; 64(1):88-93.

Darouiche RO, Mansouri MD, Schneidkraut MJ. Comparative efficacies of telavancin and vancomycin in preventing device-associated colonization and infection by Staphylococcus aureus in rabbits. Antimicrob Agents Chemother. 2009; 53(6):2626-2628.

Hernandez MD, Mansouri MD, Aslam S, Zeluff B, Darouiche RO. Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices. Infect Control Hosp Epidemiol. 2009; 30(2):190-192.

Mansouri MD, Darouiche RO. In-vivo activity and in-vitro efficacy of catheters impregnated with chloroxylenol and thymol against uropathogens. Clin Microbial Infect. 2008; 14(2):190 -192.

Darouiche RO, Mansouri MD, Gawande PV, Madhyastha S. Efficacy of combination of chlorhexidine and protamine sulfate against device-associated pathogens. J Antimicrob Chemother. 2008; 61(3):651 - 657.

Mansouri MD, Darouiche RO. In-vitro antimicrobial activity of N-acetylcysteine against bacterial colonized central venous catheters. Int J Antimicrob Agents. 2007; 29(4):474-476.

Cadle RM, Mansouri MD, Logan N, Kudva DR, Musher DM.Association of proton-pump inhibitors with outcomes in Clostridium difficile colitis. Am J Health Syst Pharm. 2007; 64(22):2359-2363.

Cadle RM, Mansouri MD, Darouiche RO. Vancomycin-induced elevation of liver enzyme levels. Ann Pharmacother. 2006; 40(6):1186-1189.

Darouiche RO, Mansouri MD, Zakarevicz D, Alsharif A, Landon GC. In-vitro efficacy of antimicrobial-coated devises in preventing device colonizationand osteomyelitis. J Bone Joint Surg. 2007; 89(4):792 - 797.

Darouiche RO, Mansouri MD, Kojic EM. Antifungal activity of antimicrobial-impregnated devices. Clin Microbiol Infect. 2006; 12(4):397-399.

Darouiche RO, Meade R, Mansouri MD, Netscher DT. In vivo efficacy of antimicrobial-impregnated saline-filled silicone implants. Plastic Reconstr Surg, 2002; 109(4):1352-1357.

Darouiche RO, Netscher DT, Mansouri MD, Meade R. Activity of antimicrobial-impregnated silicone tissue expanders. Ann Plastic Surg, 2002; 49(6):567-571.

Darouiche RO, Mansouri MD, Raad II. Efficacy of antimicrobial-impregnated silicone sections from penile implants in preventing device colonization in an animal model. Urology, 2002; 59(2):303-307.

Darouiche RO, Mansouri MD, Meade R. In-vitro and in-vivo activity of antimicrobial-coated prosthetic heart valve sewing cuffs. J Heart Valve Dis, 2002; 11(1):99-104.

Darouiche RO, Mansouri MD. In-vitro and in-vivo efficacy of antimicrobial-coated vascular grafts. Ann Vasc Surg, 2004; 18(4):497-501.

Darouiche RO, Mansouri MD. Dalbavancin compared with vancomycin for prevention of Staphylococcus aureus colonization of devices in an animal model. J Infect. 2005; 50(3):206-209.

Darouiche RO, Meade R, Mansouri M, Raad II. In vivo efficacy of antimicrobial-coated fabric from prosthetic heart valve sewing rings. J Heart Valve Dis. 1998;; 7(6):639-646.

Darouiche RO, Green G, Mansouri MD. Antimicrobial activity of antiseptic-coated orthopaedic devices. Int J Antimicrob Agents. 1998; 10(1):83-86.

Kil KS, Darouiche RO, Hull RA, Mansouri MD, Musher DM. Identification of a Klebsiella pneumoniae strain associated with nosocomial urinary tract infection. J Clin Microbiol. 1997; 35(9):2370-2374.

Raad I, Darouiche R, Hachem R, Mansouri M, Bodey GP. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J Infect Dis. 1996; 173(2):418-424.

Giulian D, Corpuz M, Chapman S, Mansouri M, Robertson C. J. Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system. Neurosci Res. 1993; 36(6):681-693.

Contact Information:
mansouri@bcm.edu

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