Recent Publication-Dr. Patrick Barth's Lab
A scan of the protein structure database looking for interhelical contacts across transmembrane protein helix trimers finds six distinct structural and topological classes with unique sequence-3D contact motifs that could prove useful in future protein design initiatives. Image: Local region (magenta) remains rigid during membrane protein function involving large conformational changes. Learn about the Barth Lab. Read the paper.
Recent Publication-Dr. Choel Kim's Lab
The first crystal structures of type I and II cGMP: cGMP complexes. The cGMP pocket of PKG II in red is shown on the left panel and that of PKG I (PDB code: 4KU7) in gray is shown on the right. Sequence alignment of PKG II (top) and PKG Ib (bottom). Conserved residues are shaded in yellow. Key cGMP contact residues in PKG II (L408, D412, and R415) and PKG I (R297 and Y351) are shaded in red.Read the paper.
Recent Publication-Dr. Yongcheng Song's Lab
Lysine specific demethylase 1 (LSD1) is a drug target for certain cancers, due to important functions of methylated histone H3 lysine 4 (H3K4). The Song laboratory designed and found potent LSD1 inhibitors that can increase cellular H3K4 methylation and strongly inhibit proliferation of several leukemia and solid tumor cells, while these compounds had negligible effects on normal cells.
Learn more about the Song Lab. Read the paper
Department of Pharmacology: About Us
The Department of Pharmacology at Baylor College of Medicine is dedicated to:
- Establishing a leading research program in drug discovery, design, and delivery
- Creating innovative approaches to facilitate drug design and discovery
- Training scientists in basic research in drug design and discovery
- Translating basic science research into therapeutic applications
- Training scientists and physicians to translate results from basic research to clinical applications
Our research interests cover a broad spectrum of topics including chemical biology, drug delivery, drug discovery, computational biology, molecular genetics and genomics, protein design, protein structure, function and evolution and psychopharmacology. Please take a moment to learn more about our diverse faculty and research.
Graduate Training Program
The Department of Pharmacology offers an advanced study program in pharmacology. The graduate program provides students with multidisciplinary training in modern pharmacology, reflecting our strong and diverse research portfolio. See more information about the Graduate Program in Pharmacology.
Please direct inquiries to Pharmacology@bcm.edu.