This program, located in the Texas Children's Cancer Center, is an internationally recognized leader in childhood cancer research and involves 28 research and 17 clinical members from a number of BCM departments including members from Pediatrics (Hematology-Oncology and Psychology), Surgery, Neurosurgery, Radiation Therapy, Medicine, Diagnostic Imaging, Pathology and Immunology.

The major themes of the center are to improve understanding of the biologic basis of pediatric cancer and to identify and develop improved methods of diagnosis, treatment and prevention. Laboratory research is largely molecular in nature and includes cancer genomic analysis of pediatric malignancies, molecular studies of cancer predisposition syndromes, investigation of cell cycle regulation in tumors and model organisms, tumor vaccine and immunology studies, identification of novel molecular targets and the development of innovative therapies. There is an integrated, comprehensive clinical research infrastructure that supports both intra-institutionally developed and cooperative group-initiated clinical trials.

The Pediatric Program has a total of 232 IRB-approved cancer related protocols including 121 clinical trials.

A competitively awarded grant supports participation in the NCI-supported Children's Oncology Group. We are one of nine national centers funded by the NCI to participate in the Pediatric Brain Tumor Clinical Trial Consortium and one of 13 NIH-funded Pediatric Pharmacology Research Units.

The TCCC has one of the largest pediatric oncology training programs in the nation and receives support for training pediatric oncology clinical researchers through an NIH K12 training grant. The TCCC is the site of the Childhood Cancer Epidemiology and Prevention Center, a joint center of Baylor College of Medicine and the MD Anderson Cancer Center, that pursues both population based and molecular epidemiology studies of childhood cancer. Cancer genetic studies are undertaken through participation in the NCI-supported Texas Cancer Genetics Consortium.

For more information, visit the Texas Children's Cancer and Hematology Centers.