About the Lab

What doesn't kill you makes you stronger. Hormesis, the paradoxical beneficial effect of low-dose stressors, can be elicited by reactive oxygen species (ROS), chemical carcinogens, calorie restriction, and physical exercise. Calorie restriction and exercise remodels redox homeostasis and energy metabolism, leading to amelioration of metabolic and neurodegenerative disorders, and extended lifespan. Thus, the beneficial effects of lifestyle management and the free radical theory of aging can be unified under the common conceptual framework of hormesis. Mechanistically, hormesis is attributed to epigenomic regulation of gene expression.

I am interested in how the environment, including external dietary environment and physical exercise or internal hormonal environment and the circadian clock, regulates metabolism and cognitive functions at the epigenomic level. We use genetic animal models, recombinant viral vectors, molecular biology approaches such as epigenomics, metabolomics, physiology, and animal behavior tests.