About the Lab

We are located in the Cullen building of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology.

Mitochondrial Proteostasis Maintenance

The research interest for the Lee Laboratory of Structural Biology is the study of mitochondrial proteostasis maintenance.

The broad and long-term research objective of the laboratory is to provide a molecular understanding of the protein quality control machinery that maintains mitochondrial proteostasis.

On-going research focuses on determining the structure, function, and mechanism of molecular chaperones, membrane-associated proteases, kinases and enzymes using a multi-pronged approach combining X-ray crystallography and cryoEM/cryoET with biochemical, biophysical, and functional studies.

The goal of our research is to provide a detailed mechanistic understanding of mitochondrial quality control proteins in order to exploit this information for rationale structure-based drug development.