About the Lab

In the Regulatory Circuits Lab we infer pathophysiological consequences of genomic variants and aberrant gene expression through analyses of molecular profiles. Towards this goal we combine computational analyses and biochemical experiments, leveraging regulatory circuits to identify new driver genes and genomic variants that act in cis or in trans. We develop methods for inferring alterations, improving expression estimates from RNA-seq data from various tissues and using various extraction methods, and inferring clonal cell populations and driving alterations based on profiles of related samples including multiple biopsies from the same patient that are taken from multiple tumor sections and before and after treatment.