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BCM - Baylor College of Medicine

Giving life to possible

Rosen Laboratory

About the Lab

Welcome to the Rosen Laboratory Website!

The research objectives of the Rosen laboratory are to elucidate the mechanisms regulating normal mammary gland development, and to determine how these regulatory mechanisms have deviated in breast cancer. 

This website provides information about ongoing research in the laboratory, current lab members, former trainees, publications, lab meeting schedule, and lab resources.

Research Interests

The research objectives of the Rosen laboratory are to elucidate the mechanisms regulating normal mammary gland development, and to determine how these regulatory mechanisms have deviated in breast cancer.

  • The role of systemic hormones, specifically prolactin, estrogens and progestins, and local growth factors, including members of the Wnt and Fgf families, in mammary gland development and breast cancer are being investigated.
  • The role of specific transcription factors and their dominant-negative isoforms, including members of the C/EBP and Stat families, are also being examined using transgenic and knockout mouse models.
  • Genetically engineered mice are being used to elucidate changes in normal mammary gland stem cells and progenitors and signal transduction pathways that are involved in the progression from the normal mammary gland to pre-neoplasias.
  • Unique preclinical syngeneic mouse models are being employed to study the response of both primary tumors and metastases to combinatorial therapies focusing on the response of tumor initiating cells.
  • Studies are underway to elucidate the mechanisms by which noncoding RNAs, both miRNAs and lncRNAs regulate mammary gland development and are altered in breast cancer.