James Versalovic Lab

Selected Peer-Reviewed Publications

Pammi M, Zhong D, Johnson Y, Revell P, Versalovic J. Polymicrobial bloodstream infections in the neonatal intensive care unit are associated with increased mortality: a case-control study. BMC infectious diseases. 2014; 14:390. PubMed
[journal] PMID: 25022748, PMCID: PMC4226990

Boonma P, Spinler JK, Venable SF, Versalovic J, Tumwasorn S. Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells. BMC microbiology. 2014; 14:177.
PubMed [journal] PMID: 24989059, PMCID: PMC4094603

Spinler JK, Sontakke A, Hollister EB, Venable SF, Oh PL, et al. From prediction to function using evolutionary genomics: human-specific ecotypes of Lactobacillus reuteri have diverse probiotic functions. Genome biology and evolution. 2014;
6(7):1772-89. PubMed [journal] PMID: 24951561, PMCID: PMC4122935

Boonma P, Spinler JK, Qin X, Jittaprasatsin C, Muzny DM, et al. Draft genome sequences and description of Lactobacillus rhamnosus strains L31, L34, and L35. Standards in genomic sciences. 2014; 9(3):744-54. PubMed [journal] PMID:
25197459, PMCID: PMC4148986

Thiraworawong T, Spinler JK, Werawatganon D, Klaikeaw N, Venable SF, et al. Anti-inflammatory properties of gastric-derived Lactobacillus plantarum XB7 in the context of Helicobacter pylori infection. Helicobacter. 2014; 19(2):144-55.
PubMed [journal] PMID: 24387083

Hemarajata P, Spinler JK, Balderas MA, Versalovic J. Identification of a proton-chloride antiporter (EriC) by Himar1 transposon mutagenesis in Lactobacillus reuteri and its role in histamine production. Antonie van Leeuwenhoek. 2014; 105(3):579-92. NIHMSID: NIHMS562360 PubMed [journal] PMID:
24488273, PMCID: PMC4011013

Hemarajata P, Gao C, Pflughoeft KJ, Thomas CM, Saulnier DM, et al. Lactobacillus reuteri-specific immunoregulatory gene rsiR modulates histamine production and immunomodulation by Lactobacillus reuteri. Journal of bacteriology. 2013;
195(24):5567-76. PubMed [journal] PMID: 24123819, PMCID: PMC3889603

Pammi M, Liang R, Hicks J, Mistretta TA, Versalovic J. Biofilm extracellular DNA enhances mixed species biofilms of Staphylococcus epidermidis and Candida albicans. BMC microbiology. 2013; 13:257. PubMed [journal] PMID: 24228850, PMCID:

Diaz MA, Bik EM, Carlin KP, Venn-Watson SK, Jensen ED, et al. Identification of Lactobacillus strains with probiotic features from the bottlenose dolphin (Tursiops truncatus). Journal of applied microbiology. 2013; 115(4):1037-51.
PubMed [journal] PMID: 23855505, PMCID: PMC4063339

Saulnier DM, Ringel Y, Heyman MB, Foster JA, Bercik P, et al. The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut microbes.2013; 4(1):17-27. PubMed [journal] PMID: 23202796, PMCID: PMC3555881

Nagy-Szakal D, Hollister EB, Luna RA, Szigeti R, Tatevian N, et al. Cellulose supplementation early in life ameliorates colitis in adult mice. PloS one. 2013; 8(2):e56685. PubMed [journal] PMID: 23437211, PMCID: PMC3577696

Hemarajata P, Versalovic J. Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therapeutic advances in gastroenterology. 2013; 6(1):39-51. PubMed [journal] PMID: 23320049, PMCID:

Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, et al. Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice. Journal of pediatric gastroenterology and nutrition. 2012; 55(3):299-307.
NIHMSID: NIHMS551675 PubMed [journal] PMID: 22343914, PMCID: PMC4010314

A framework for human microbiome research. Nature. 2012; 486(7402):215-21. NIHMSID: NIHMS376809 PubMed [journal] PMID: 22699610, PMCID: PMC3377744

Structure, function and diversity of the healthy human microbiome. Nature. 2012; 486(7402):207-14. NIHMSID: NIHMS378076 PubMed [journal] PMID: 22699609, PMCID: PMC3564958

Johnson CL, Versalovic J. The human microbiome and its potential importance to pediatrics. Pediatrics. 2012; 129(5):950-60. PubMed [journal] PMID: 22473366, PMCID: PMC3340594

Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, et al. Probiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine. FASEB journal : official publication of the Federation of American
Societies for Experimental Biology. 2012; 26(5):1960-9. PubMed [journal] PMID: 22267340, PMCID: PMC3336785

Thomas CM, Hong T, van Pijkeren JP, Hemarajata P, Trinh DV, et al. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PloS one. 2012; 7(2):e31951. PubMed [journal] PMID: 22384111,
PMCID: PMC3285189

Pflughoeft KJ, Versalovic J. Human microbiome in health and disease. Annual review of pathology. 2012; 7:99-122. PubMed [journal] PMID: 21910623

Pammi M, Liang R, Hicks JM, Barrish J, Versalovic J. Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. Pediatric research. 2011; 70(6):578-83. NIHMSID: NIHMS324772 PubMed [journal]
PMID: 21857375, PMCID: PMC3210893

Saulnier DM, Riehle K, Mistretta TA, Diaz MA, Mandal D, et al. Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome. Gastroenterology. 2011; 141(5):1782-91. NIHMSID: NIHMS310959 PubMed [journal]
PMID: 21741921, PMCID: PMC3417828

Pammi M, Flores A, Leeflang M, Versalovic J. Molecular assays in the diagnosis of neonatal sepsis: a systematic review and meta-analysis. Pediatrics. 2011; 128(4):e973-85. PubMed [journal] PMID: 21949139

Santos F, Spinler JK, Saulnier DM, Molenaar D, Teusink B, et al. Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis. Microbial cell
factories. 2011; 10:55. PubMed [journal] PMID: 21777454, PMCID: PMC3162504

Whary MT, Taylor NS, Feng Y, Ge Z, Muthupalani S, et al. Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice. Immunology. 2011; 133(2):165-78.
PubMed [journal] PMID: 21426337, PMCID: PMC3088979

Kellermayer R, Dowd SE, Harris RA, Balasa A, Schaible TD, et al. Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice. FASEB journal : official publication of the Federation of
American Societies for Experimental Biology. 2011; 25(5):1449-60. PubMed [journal] PMID: 21228220, PMCID: PMC3079304

Saulnier DM, Santos F, Roos S, Mistretta TA, Spinler JK, et al. Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features. PloS one. 2011;
6(4):e18783. PubMed [journal] PMID: 21559529, PMCID: PMC3084715

Jones SE, Whitehead K, Saulnier D, Thomas CM, Versalovic J, et al. Cyclopropane fatty acid synthase mutants of probiotic human-derived Lactobacillus reuteri are defective in TNF inhibition. Gut microbes. 2011; 2(2):69-79. PubMed [journal]
PMID: 21637024, PMCID: PMC3225771

Preidis GA, Hill C, Guerrant RL, Ramakrishna BS, Tannock GW, et al. Probiotics, enteric and diarrheal diseases, and global health. Gastroenterology. 2011; 140(1):8-14. NIHMSID: NIHMS254327 PubMed [journal] PMID: 21075108, PMCID:

Venkatesh M, Flores A, Luna RA, Versalovic J. Molecular microbiological methods in the diagnosis of neonatal sepsis. Expert review of anti-infective therapy. 2010; 8(9):1037-48. NIHMSID: NIHMS236972 PubMed [journal] PMID: 20818947, PMCID:

O'Flaherty S, Saulnier DM, Pot B, Versalovic J. How can probiotics and prebiotics impact mucosal immunity? Gut microbes. 2010; 1(5):293-300. PubMed [journal] PMID: 21327037, PMCID: PMC3023613

Thomas CM, Versalovic J. Probiotics-host communication: Modulation of signaling pathways in the intestine. Gut microbes. 2010; 1(3):148-63. PubMed [journal] PMID: 20672012, PMCID: PMC3023596

Venkatesh M, Rong L, Raad I, Versalovic J. Novel synergistic antibiofilm combinations for salvage of infected catheters. Journal of medical microbiology. 2009; 58(Pt 7):936-44. PubMed [journal] PMID: 19502361

Mason EO, Lamberth LB, Hammerman WA, Hulten KG, Versalovic J, et al. Vancomycin MICs for Staphylococcus aureus vary by detection method and have subtly increased in a pediatric population since 2005. Journal of clinical microbiology. 2009;
47(6):1628-30. PubMed [journal] PMID: 19403769, PMCID: PMC2691127

McDade-Ngutter C, Versalovic J, Alexander W, Hubbard VS, Starke-Reed P, et al. National Institutes of Health Gastrointestinal Microbiota and Advances in Prebiotic and Probiotic Research conference summary. Gastroenterology. 2009;
136(5):1473-5. PubMed [journal] PMID: 19328204

Petrosino JF, Highlander S, Luna RA, Gibbs RA, Versalovic J. Metagenomic pyrosequencing and microbial identification. Clinical chemistry. 2009; 55(5):856-66. NIHMSID: NIHMS201849 PubMed [journal] PMID: 19264858, PMCID:

Preidis GA, Versalovic J. Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era. Gastroenterology. 2009; 136(6):2015-31. NIHMSID: NIHMS594697 PubMed [journal]
PMID: 19462507, PMCID: PMC4108289

Saulnier DM, Spinler JK, Gibson GR, Versalovic J. Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Current opinion in biotechnology. 2009; 20(2):135-41. NIHMSID: NIHMS93506 PubMed [journal] PMID:
19243931, PMCID: PMC2713183

Taweechotipatr M, Iyer C, Spinler JK, Versalovic J, Tumwasorn S. Lactobacillus saerimneri and Lactobacillus ruminis: novel human-derived probiotic strains with immunomodulatory activities. FEMS microbiology letters. 2009; 293(1):65-72.
NIHMSID: NIHMS598623 PubMed [journal] PMID: 19222575, PMCID: PMC4105522

Jones SE, Versalovic J. Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors. BMC microbiology. 2009; 9:35. PubMed [journal] PMID: 19210794, PMCID: PMC2653509

Hsieh MH, Versalovic J. The human microbiome and probiotics: implications for pediatrics. Current problems in pediatric and adolescent health care. 2008; 38(10):309-27. NIHMSID: NIHMS79400 PubMed [journal] PMID: 18992706, PMCID:

 Lin YP, Thibodeaux CH, Peña JA, Ferry GD, Versalovic J. Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun. Inflammatory bowel diseases. 2008; 14(8):1068-83. PubMed [journal] PMID: 18425802

Reid G, Gibson G, Sanders ME, Guarner F, Versalovic J. Probiotic prophylaxis in predicted severe acute pancreatitis. Lancet (London, England). 2008; 372(9633):112-3; author reply 114. PubMed [journal] PMID: 18620940

Iyer C, Kosters A, Sethi G, Kunnumakkara AB, Aggarwal BB, et al. Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling. Cellular
microbiology. 2008; 10(7):1442-52. PubMed [journal] PMID: 18331465

Spinler JK, Taweechotipatr M, Rognerud CL, Ou CN, Tumwasorn S, et al. Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens. Anaerobe. 2008;
14(3):166-71. NIHMSID: NIHMS57384 PubMed [journal] PMID: 18396068, PMCID: PMC2494590

Boyanton BL Jr, Luna RA, Fasciano LR, Menne KG, Versalovic J. DNA pyrosequencing-based identification of pathogenic Candida species by using the internal transcribed spacer 2 region. Archives of pathology & laboratory
medicine. 2008; 132(4):667-74. PubMed [journal] PMID: 18384218

Whitehead K, Versalovic J, Roos S, Britton RA. Genomic and genetic characterization of the bile stress response of probiotic Lactobacillus reuteri ATCC 55730. Applied and environmental microbiology. 2008; 74(6):1812-9. PubMed
[journal] PMID: 18245259, PMCID: PMC2268311

Complete List of publication.