About the Lab

Our research focuses on brain states and multimodal integration across corticothalamic circuits. Information processing in the brain varies between brain states like sleep and wakefulness, and also more subtly between attention and inattention. When we are driving a car for example, and our attention shifts from the scene in front of us to the song on the radio, the processing of auditory and visual information can change dramatically without any anatomical rewiring of circuits in the brain. We study the mechanisms underlying the differential gating and routing of information in multiple sensory areas during these brain state changes. To address this difficult problem we record and manipulate activity in awake mice using cutting-edge techniques like targeted in vivo whole-cell patching, advanced multiphoton calcium imaging, optogenetics, and viral techniques.