Laising Yen Lab



Kannan, K, C. Coarfa, P-W Chao, L. Luo, Y. Wang, A. E. Brinegar, S. Hawkins, A. Milosavljevic, M. Matzuk, and L. Yen. A recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. Proc Natl Acad Sci USA. 112:E1272-7 (2015).

Khraiwesh B., B. Kenan Jijakli, Joseph Swift, Amphun Chaiboonchoe, Pei-Wen Chao, L. Yen, and Kourosh Salehi-Ashtiani. Perspective applications of synthetic biology for algal bioproducts optimization. Biofuel and Biorefinery Technologies 2:137-54 (2015).

Kalpana, K, C. Coarfa, K. Rajapakshe, S. Hawkins, M. Matzuk, A. Milosavljevic, and L. Yen. CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genetics 10:e1004216 (2014).

Zhang H, W. Lin, K. Kannan, L. Luo, J. Li, P-W Chao, Y. Wang, Y-P Chen, J. Gu, and L. Yen. Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. Oncotarget 4:2135-43 (2013).

Wu CC, Kannan K, Lin S, L. Yen, Milosavljevic A. Identification of cancer fusion drivers using network fusion centrality. Bioinformatics 29:1174-81 (2013).

Kalpana Kannan, Liguo Wang, Jianghua Wang, Michael Ittmann, Wei Li, and L. Yen. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep-sequencing. Proc Natl Acad Sci USA 108:9172-7 (2011).

Wang, L., Y. Xi, J. Yu, L. Dong, L. Yen, and W. Li. A Statistical Method for the Detection of Alternative Splicing Using RNA-seq. PLoS One 5:e8529 (2010).

Yen, L., B.R. Stockwell, and R.C. Mulligan. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods in Molecular Biology, 540:335 (2009).

Link K.H., L. Guo, T. Ames, L. Yen, R.C. Mulligan, and R.R. Breaker. Engineering high speed allosteric hammerhead ribozymes. Biological Chemistry, 388:779-86 (2007).

Yen, L., M. Magnier, R. Weissleder, B.R. Stockwell, and R.C. Mulligan. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA, 12:797-806 (2006).

Yen, L., J. Svendsen, J-S. Lee, J.T. Gray, M. Magnier, T. Baba, R.J. D’Amato and R.C. Mulligan. Exogenous control of mammalian gene expression via modulation of RNA self-cleavage. Nature, 431:471-6 (2004).

Yen, L. and R.G. Kalb. Reduction of functional NMDA Receptor in neurons by RNase P-mediated cleavage of the NR1 mRNA. J. Neurochem. 76:1-10 (2001).

Yen, L., S.M. Strittmatter and R.G. Kalb. Sequence-specific cleavage of Huntington mRNA by catalytic DNA. Annals of Neurology, 46:366-73 (1999).

Yen, L. and R.G. Kalb. Recovery from spinal cord injury: New approaches. Neuroscientist, 1:321-7 (1995).

Jakowec, M.W., L. Yen and R.G. Kalb. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience 67:909-20 (1995).

Yen, L., J. Sibley and M. Constantine-Paton. Analysis of synaptic distribution within single retinal axonal arbors after NMDA treatment. J. Neurosci. 15:4712-25 (1995).

Yen, L-H., J. Sibley and M. Constantine-Paton. Fine-structural alterations and clustering of developing synapses after chronic treatment with low levels of NMDA. J. Neurosci. 13:4949-60 (1993).