Functional and Cognitive Neurophysiology Laboratory

Master
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Ask Me About My Research

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Sameer Sheth, M.D., Ph.D., associate professor and vice-chair of clinical research in the department neurosurgery is joined by a special guest to demonstrate the importance of scientists and researchers talking with others about their work.

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Dr. Ashwin Viswanathan and Dr. Samir Sheth
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Baylor St. Luke’s adopts new Parkinson’s disease treatment

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New technology in deep brain stimulation is making treatment of Parkinson’s disease more precise and easier to maintain for the millions of people living with the debilitating disease

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About the Lab

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The Functional and Cognitive Neurophysiology laboratory, led by Dr. Sameer Sheth, focuses on the study of human decision-making and cognition, as well as on the development of novel therapies for neuropsychiatric disorders. To accomplish these goals, we take a two-fold approach. First, we work with neurosurgical patients undergoing deep brain stimulation (DBS), epilepsy monitoring, and other procedures that require the placement of intracranial electrodes. We use single-neuron and field potential recordings as well as stimulation to understand the circuitry underlying complex cognitive functions such as controlled decision-making, memory formation, and emotional regulation. Second, we develop and refine neuromodulatory treatments for refractory neurological and psychiatric disorders such as obsessive-compulsive disorder (OCD), depression, and many others. These disorders often arise from dysfunction in the same circuits mentioned above. Thus the two efforts advance synergistically, with a constant back-and-forth flow of ideas. Because of the multi-disciplinary nature of this work, the lab interacts closely with many other disciplines, including Neuroscience, Psychiatry, Neurology, Computational Science, Engineering, and others.

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Research Projects

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  • Investigating the physiology of human decision-making in prefrontal cortex
  • Investigating cortical and basal ganglia networks involved in disorders of mental health
  • Developing novel targets and indications for neuromodulation
  • Investigating the coupling between neuronal activity and hemodynamics in human cortex
Review our current Research Projects