Sameer Anil Sheth, M.D., Ph.D.

Professor

Request Clinical Appointment

Email

sasheth@bcm.edu

Positions

Professor: Neurosurgery
Baylor College of Medicine
Houston, Texas, United States

Vice Chair of Research: Neurosurgery
Baylor College of Medicine
Houston, Texas, United States

McNair Scholar: Baylor College of Medicine
Houston, Texas, United States

Cullen Foundation Endowed Chair: Neurosurgery
Baylor College of Medicine
Houston, Texas, United States

Addresses

Baylor College of Medicine McNair Campus (Clinic): 7200 Cambridge
9th Floor
Houston, TX, 77030
United States
Phone: (713) 798-4696

BCM-Smith Medical Research Bldg (Lab): Room: BCMS-S104
Houston, TX, 77030
United States

Education

MD from University of California Los Angeles: Los Angeles, California, United States

PhD from University of California Los Angeles: Los Angeles, California, United States

Fellowship at Massachusetts General Hospital, Harvard Medical School: Boston, Massachusetts, United States; Functional and Stereotactic Neurosurgery

Residency at Massachusetts General Hospital: Boston, Massachusetts, United States

BS from Harvard University: Cambridge, Massachusetts, United States; Physics, Astronomy

Websites

Baylor St. Luke’s adopts new Parkinson’s disease treatment

Dr. Sheth is featured in this article about new technology in deep brain stimulation.

Exploring Advances in Epilepsy Treatment

This article featuring Dr. Sheth describes advances in epilepsy treatment options.

Pioneers in DBS Therapy

Baylor College of Medicine and Baylor St. Lukes Medical Center are pioneering new therapies for a range of neurological conditions. Read about Dr. Sheth's work advancing deep brain stimulation (DBS) therapy here.

Functional and Cognitive Neurophysiology Laboratory

This lab focuses on the study of human decision-making and cognition, as well as on the development of novel therapies for neuropsychiatric disorders. To accomplish these goals, we take a two-fold approach.

Videos

Webinar on surgical treatment of tremor

Along with colleagues Nora Vanegas, MD, and Ashwin Viswanathan, MD, we provide a patient-focused information session on the surgical treatment of tremor.

Selected Publications

Ah Lee S, Miller JF, Watrous AJ,Sheth S, Das SR, Stein JM, Gorniak R, Rizzuto DS, Jacobs J.. " Electrophysiological signatures of spatial boundaries in the human subiculum. " J Neurosci. 2018 Feb 21;
Pubmed PMID: 29467145.
Bari AA, Mikell CB, Abosch A,Sheth SA.. " Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders. " J Neurol Neurosurg Psychiatry. 2018 Jan 25;
Pubmed PMID: 29371415.
Youngerman BE, Oh JY, Anbarasan D,Sheth SA, McKhann GM. " Laser ablation is effective for temporal lobe epilepsy with and without mesial temporal sclerosis if hippocampal seizure onsets are localized by stereoelectroencephalography " Epilepsia. 2018 Feb 2;
Pubmed PMID: 29392715.
Solomon E, Kragel J, Sperling M,Sheth SA, Rizzuto S, Kahana M.. " Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition. " Nat Commun.. 2017 Nov 22;
Pubmed PMID: 29167419.
Nanda P, Banks GP, Pathak YJ, Sheth SA.. " Connectivity-Based Parcellation of the Anterior Limb of the Internal Capsule.” Human Brain Mapping " Human Brain Mapping. 2017 Sep 14; 38 (12) : 6107–6117.
Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana M, Rizzuto DS. " Direct electrical stimulation of the human entorhinal region and hippocampus impairs memory. " Neuron.. 2016 Dec 7;
Pubmed PMID: 27930911.
Banks G, Mikell CB, Youngerman BE,Sheth SA.. " Neuroanatomical Characteristics Associated With Response to Dorsal Anterior Cingulotomy for Obsessive-Compulsive Disorder " JAMA Psychiatry. 2015 Feb ;
Smith EH, Banks GP, Mikell CB, Cash, Sheth SA.. " Frequency-dependent representation of reinforcement-related information in human medial and lateral prefrontal cortex.” " J Neurosci.. 2015 Dec 2;
Pubmed PMID: 26631465.
Mikell CB, Sinha S, Sheth SA. " Neurosurgery for schizophrenia: An update on pathophysiology and a novel therapeutic target. " J Neurosurg.. 2016 Apr 12;
Pubmed PMID: 26517767.
Sheth SA, Neal J, Tangherlini F, Mian MK, Gentil A, Cosgrove GR, Eskandar EN, Dougherty DD. " Limbic system surgery for treatment-refractory obsessive-compulsive disorder: five-year prospective follow-up in 64 patients " J Neurosurg.. 2013 Mar 11;
Pubmed PMID: 23240700.
Sheth SA, Mian MK, Patel SR, Asaad WF, Williams ZM, Dougherty DD, Bush G, Eskandar EN.. " Human dorsal anterior cingulate neurons mediate ongoing behavioral adaptation " Nature. 2012 Aug 9;

Funding

Cognitive Control Mechanisms in Human Prefrontal Cortex #R01 MH106700: NIH

Deep Brain Stimulation for Depression Using Directional Current Steering and Individualized Network Targeting #UH3 NS103549: NIH

Investigating the role of medial and lateral prefrontal cortex in human decision-making: Dana Foundation

Mechanisms of Rapid, Flexible Cognitive Control in Human Prefrontal Cortex #U01 NS108923: NIH