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Eric Chang Lab



Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. 2015. Wild type N-Ras, overexpressed in basal-like breast cancer, promotes tumor formation by inducing IL8 secretion via JAK2 activation. Cell Rep. 21;12(3):511-24.

Veeraraghavan J, Tan Y, Cao XX, Kim JA2 Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS. 2014. Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of estrogen-receptor positive breast cancers. Nat Commun. 5: 4577.

Young E, Zheng ZY, Wilkins AD, Jeong HT, Li M, Lichtarge O, Chang EC. 2014. Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Mol Cell Biol. 34:374-5.

Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. 2012. CHMP6 and VPS4A mediate recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene. 31: 4630-8.

Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. 2011. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 30: 724-36.

Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC*, Wolf DA. 2009. The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol Cell. 36 141-52. (*shared corresponding authorship with Wolf)

Onken B, Wiener H, Philips MR, Chang EC. 2006. Compartmentalized signaling of Ras in fission yeast. Proc Natl Acad Sci USA. 103: 9045-50.

Yen HC, Gordon C, Chang EC. 2003. Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. Cell. 112: 207-17.

Papadaki P, Pizon V, Onken B, Chang EC. 2002. Two Ras pathways in fission yeast are differentially regulated by two Ras guanine nucleotide exchange factors. Mol Cell Biol. 22: 4598-606.

Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. 1994. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell. 79: 131-41.


Cell Reports Article


Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation