Positions

Associate Professor - Sarah Campbell Blaffer Endowed Chair
Ophthalmology
Baylor College of Medicine
Houston, TX, US

Education

PhD from Michigan State University
Biochemistry
Postdoctoral Fellowship at Johns Hopkins University School of Medicine
Visual Neurophysiology
BS from Peking University
Biochemistry

Honors & Awards

Audacious Goals Challenge Prize
https://www.nei.nih.gov/news/pressreleases/020813
The Helen Juanita Reed Award for Macular Degeneration Research

Professional Interests

  • Protein trafficking
  • Retinal degeneration including retinitis pigmentosa & age-related macular degeneration
  • Gene editing based therapy

Professional Statement

The Fu lab is interested in using the visual system to study protein trafficking, sensory transduction, the biological mechanisms underlying various types of neurodegeneration and to develop innovative treatment strategies. Recently, the Fu lab has made significant progress toward the understanding of two blinding diseases: Leber congenital amaurosis (LCA), the most severe retinal dystrophy in early childhood, and age-related macular degeneration, the leading cause of irreversible blindness in the elderly. The PI has won the National Eye Institute Audacious Goals Challenge Prize (http://www.nei.nih.gov/challenge). A recent exciting project in the lab is to permanently correct disease-associated mutations in a patient using molecules that are specially designed to target mutated DNA sequences (such as CRISPR) and that can be delivered safely and efficiently into the tissue. Such strategies could potentially provide the best cure or prevention for many diseases, which has the potential to forever transform healthcare.

The Fu lab is particularly interested in using the visual system to address post-genomic era challenges (e.g. translate enormous genetic information to functional information). We place emphasis in "Translational Research": from “discovering mechanisms” to “developing innovative treatment strategies” to “moving into clinical trials”. Due to the translational nature of our research, students and postdocs will have good employment opportunities in both academia and industry. With diverse research projects (from basic to translational), there is ample opportunity for incoming students. We welcome rotation students!

The Fu lab is currently has one position open for a postdoc/research associate and one position open for a technician. Highly motivated candidates who are interested in addressing major health challenges facing our modern society are encouraged to apply.

Selected Publications

Memberships

Association for Research in Vision and Ophthalmology