Ying H Shen, M.D., Ph.D.

Professor of Surgery

Email

hyshen@bcm.edu

Positions

Professor of Surgery: Division of Cardiothoracic Surgery
Baylor College of Medicine

Director, Aortic Disease Research Laboratory: Baylor College of Medicine

Addresses

Cardiothoracic Surgery Research Laboratory (Lab): Texas Heart Institute
6770 Bertner Ave.
Houston, TX, 77030
United States
Phone: (832) 355-9952

Education

PhD from University Of New South Wales: Sydney, NSW, Australia

MD from Beijing Medical College: Beijing, China

Honors & Awards

Dr. Mark L. Entman Teaching Award for Excellence in Cardiovascular Education: Cardiovascular Research Institute (05/2023)

Professional Interests

Aortic aneurysms and dissections
Diabetic vascular diseases
Vascular biology and diseases

Professional Statement

Dr. Ying Shen's research focuses on Vascular Diseases. One of her main interests is in the molecular mechanisms of aortic aneurysms and dissections. During the past few years, she has developed several projects investigating the signaling pathways that control aortic destruction, healing, and remodeling. She has also established mouse models of aortic aneurysms and dissections and used various techniques to evaluate the aortic structure and function. The ultimate goal of Dr. Shen’s research is to use pharmacological treatment to prevent progressive aortic destruction and disease deterioration.

Websites

Dr. Shen's Research

VIICTR Research Database

Drs. Shen and LeMaire Awarded NHLBI R01 Grant

Aortic Disease Research Laboratory

Grant to fund study on gender differences in aortic disease

Selected Publications

Chakraborty A, Li Y, Zhang C, Li Y, Rebello KR, Li S, Xu S, Vasquez HG, Zhang L, Luo W, Wang G, Chen K, Coselli JS, LeMaire SA, Shen YH.. " Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections " Circulation. 2023 Sep 19; 142 : 959-977.
Pubmed PMID: 37555319.
Zhang C, Li Y, Chakraborty A, Li Y, Rebello KR, Ren P, Luo W, Zhang L, Lu HS, Cassis LA, Coselli JS, Daugherty A, LeMaire SA, Shen YH.. " Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice. " Arterioscler Thromb Vasc Biol.. 2023 Feb ; 43 (2) : 234-252.
Pubmed PMID: 36579645.
LeMaire SA, Zhang L, Zhang NS, Luo W, Barrish JP, Zhang Q, Coselli JS, Shen YH.. " Ciprofloxacin accelerates aortic enlargement and promotes dissection and rupture in Marfan mice. " J Thorac Cardiovasc Surg. 2022 Mar ; 163 (3) : e215-e226.
Li Y, Ren P, Dawson A, Vasquez HG, Ageedi W, Zhang C, Luo W, Chen R, Li Y, Kim S, Lu HS, Cassis LA, Coselli JS, Daugherty A, Shen YH, LeMaire SA.. " Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue " Circulation. 2020 Oct ; 142(14) : 1374-1388.
Pubmed PMID: 33017217.
Luo W, Wang Y, Zhang L, Ren P, Zhang C, Li Y, Azares AR, Zhang M, Guo J, Ghaghada KB, Starosolski ZA, Rajapakshe K, Coarfa C, Li Y, Chen R, Fujiwara K, Abe JI, Coselli JS, Milewicz DM, LeMaire SA, Shen YH. " Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture " Circulation. 2020 Jan ; 141(1) : 42-66.
Pubmed PMID: 31887080.
LeMaire SA, Zhang L, Luo W, Ren P, Azares AR, Wang Y, Zhang C, Coselli JS, Shen YH.. " Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. " JAMA Surg. 2018 Sep ; 153(9) : e181804..
Pubmed PMID: 30046809.
Wu D, Ren P, Zheng Y, Zhang L, Xu G, Xie W, Lloyd EE, Zhang S, Zhang Q, Curci JA, Coselli JS, Milewicz DM, Shen YH, LeMaire SA.. " NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation. " Arterioscler Thromb Vasc Biol. 2017 Apr ; 37(4) : 694-706.
Pubmed PMID: 28153878.
Mao Y, Luo W, Zhang L, Wu W, Yuan L, Xu H, Song J, Fujiwara K, Abe JI, LeMaire SA, Wang XL, Shen YH.. " STING–IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity " Arterioscler Thromb Vasc Biol.. 2017 May ; 37(5) : 920-929.
Pubmed PMID: 28302626.
Yuan L, Mao Y, Luo W, Wu W, Xu H, Wang XL, Shen YH. " Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism. " J Biol Chem. 2017 Sep ; 292(36) : 15002-15015.
Pubmed PMID: 28698384.
Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhang L, Wu D, Zhang C, Curci JA, Coselli JS, Milewicz DM, LeMaire SA, Shen YH.. " Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. " Sci Rep. 2017 Sep 27; 7(1): : 12351..
Pubmed PMID: 28955046.
Shen YH, Zhang L, Ren P, Nguyen MT, Zou S, Wu D, Wang XL, Coselli JS, Lemaire SA. " AKT2 Confers Protection Against Aortic Aneurysms and Dissections " Circ Res. 2013 Feb ; 112(4) : 618-32.
Pubmed PMID: 23250987.
Li XN, Song J, Zhang L, LeMaire SA, Hou X, Zhang C, Coselli JS, Chen L, Wang XL, Zhang Y, Shen YH. " Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. " Diabetes. 2009 Oct ; 58(10) : 2246-57.
Pubmed PMID: 19592618.
Wang XL, Zhang L, Youker K, Zhang MX, Wang J, LeMaire SA, Coselli JS, Shen YH. " Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase " Diabetes. 2006 Aug ; 55(8) : 2301-10.
Pubmed PMID: 16873694.
Shen YH, Utama B, Wang J, Raveendran M, Duraisamy S, Waldman WJ, Belcher J, Vercellotti G, Martin D, Mitchelle B, Wang XL. " Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways " Circ Res. 2004 May ; 94(10) : 1310-7.
Pubmed PMID: 15105295.