Positions

Assistant Professor
Neurology, Neuroscience, and Psychiatry & Behavioral Sciences
Baylor College of Medicine
Principal Investigator
Laboratory of Epilepsy and Emotional Behavior
Baylor College of Medicine
Adjunct Assistant Professor
Electrical and Computer Engineering
Rice University

Education

BS from New York University
Neuroscience (Hons), Chemistry
MD-PhD from University of Texas Southwestern Med. Center Medical Scientist Training Program (MSTP)
PhD: Behavioral Neuroscience, Molecular Neuroplasticity
Internship at Parkland Memorial Hospital/University of Texas Southwestern
Internal Medicine
Residency at Beth Israel Deaconess Medical Center, Harvard Medical School
Adult Neurology
Postdoctoral Fellowship at Beth Israel Deaconess Medical Center, Harvard Medical School
Seizures and autism-related behavior, mouse models of autism and epilepsy
Clinical Fellowship at Beth Israel Deaconess Medical Center, Harvard Medical School
Clinical Neurophysiology and Epilepsy

Certifications

Adult Neurology (2014)
American Board of Psychiatry and Neurology
Clinical Neurophysiology (2017)
American Board of Psychiatry and Neurology
Epilepsy Medicine (2018)
American Board of Psychiatry and Neurology

Honors & Awards

Outstanding Resident Teaching Award
NINDS R25 Award
Clinical Research Training Fellowship in Epilepsy
Mentored Clinical Scientist Research Career Development Award K08
Junior Faculty Seed Grant

Professional Interests

  • Epilepsy and Mental Health Disorders
  • Comorbid Epileptic and Psychogenic Nonepileptic Seizures
  • Comorbid treatment-refractory depression AND epilepsy
  • Behavioral Phenotyping in Mouse Models of Neuropsychiatric Illness
  • Home Cage Monitoring

Professional Statement

I am proud to be a physician-scientist at the Baylor Comprehensive Epilepsy Center. I am an adult neurologist with expertise in treating epilepsy (an "epileptologist") and the interpretation of electroencephalograms (EEGs) and other neuromonitoring techniques (a "clinical neurophysiologist"). I have a special interest in caring for patients with epilepsy and comorbid mental health conditions (such as depression/anxiety, psychogenic nonepileptic seizures, schizophrenia, or autism). My laboratory uses mouse models of epilepsy to explain how certain brain "lesions" that produce hyperexcitability (or medications that treat hyperexcitability) may give rise to pervasive alterations in emotional behavior and social drive (www.bcm.edu/krishnanlab).

I received a PhD in Neuroscience as a part of a combined MDPhD program. For my PhD, I used mouse models of psychosocial stress to understand how certain molecular and cellular changes in specific brain regions underlie whether an animal may be vulnerable or resilient to the psychopathological effects of chronic stress. After my clinical training, I completed a postdoctoral fellowship in neurobiology, where I examined how the experience of recurrent seizures result in long lasting alterations in neuronal physiology that may give rise to changes in sociability.

My scientific goals are to understand the biology underlying the intersections between seizures, epilepsy and psychiatric symptoms/mental health disorders. I hope to build a systematic approach to treating epilepsy as a spectrum disorder, where a distributed network-based "lesion" gives rise to both "ictal" changes (brief, paroxysmal and stereotyped abnormalities of neurological function) and "interictal" changes (pervasive aberrations in mood, anxiety, activity or sociability). My goal is for this work to be translated into a comprehensive pathophysiology-based approach to treating epilepsy spectrum disorders where seizures and psychiatric/cognitive derangements are addressed with equal importance through a comprehensive team of care providers. Towards this goal, I direct the Laboratory of Epilepsy and Emotional Behavior at the Baylor College of Medicine, where we apply state of the art behavioral monitoring techniques in mice to carefully dissect how genetic vulnerabilities that result in epilepsy or elevated seizure risk impact activity, anxiety, motivation and sociability.

Selected Publications

Memberships

American Academy of Neurology
American Epilepsy Society
NINDS/AES Epilepsy Benchmark Stewards Committee