Positions

Assistant Professor
Pediatrics-Nutrition
Baylor College of Medicine
Houston, TX, US

Education

Postdoctoral Fellowship at University Of California, San Francisco
PhD from University Of Texas At Austin

Professional Statement

Research Interests

Dysregulation of developmentally expressed signaling pathways during fetal development, early childhood, or even adulthood can significantly contribute to the development of chronic diseases, such as heart disease, obesity, and type II diabetes. Our lab is currently investigating the role of one of these signaling pathways, the Hedgehog (Hh) signaling pathway, in the specification of adipose cell lineages in vertebrates. By using a combination of mouse genetic, molecular, and developmental biology, biochemical approaches, we hope to develop a broad understanding of the molecular mechanisms underlying adipose tissue formation.

Selected Publications

  • Yu D-H, Waterland R, Zhang PM, Schady D, Chen M-H, Guan YT, Gadkari M, Shen L-L. "Targeted p16Ink4a epimutation causes tumorigenesis in mice in vivo." J Clin Invest. 2014;124(9):3708-3712.
  • Lin C-W, Chen M-H, Yao E, Song H, Gacayan R, Hui C-C, and Chuang P-T. "Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.." Dev. Bio. 2014;392:324-333.
  • Zhulyn O, Li D, Deimling S, Vakili N, Mo R, Puviindran V, Chen M-H, Chuang P-T, Hopyan S, and Hui CC.. "A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.." Dev Cell. 2014;29(2):241-249.
  • Chen M-H and Tong Qiang. "An Update on the Regulation of Adipogenesis.." Drug Discov Today Dis Mech. 2013;10(1):e15-e19.
  • Yu DH, Ware C, Waterland RA, Zhang J, Chen MH, Gadkari M, Kunde-Ramamoorthy G, Nosavanh LM, Shen L. "Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation.." Mol. Cell. Biol.. 2013;33(9):1845-58.
  • Song H, Yao E, Lin CW, Gacayan R, Chen M-H, and Chuang P-T.. "Functional characterization of pulmonary neuroendocrine cells in lung development, injury and tumorigenesis.." Proc Natl Acad Sci USA. 2012;109(43):17531-17536.
  • 2. Chen M-H, Wilson CW, Li YJ, Law KK, Lu C-S, Gacayan R, Zhang X, Hui C-C, Chuang P-T. "Cilium independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.." Genes Dev. 2009;23(16):1901-1928.
  • 9. Wilson CW, Nguyen C, Chen M-H, Yang J-H, Gacayan R, Chen J-N, Chuang P-T.. "Fused has evolved divergent roles in vertebrate Hedgehog signaling and motile ciliogenesis.." Natur. 2009;459(7243):98-102.