Positions

Director
Center for Drug Discovery
Baylor College of Medicine
Stuart A. Wallace Chair and Professor
Department of Pathology & Immunology
Baylor College of Medicine
Robert L. Moody, Sr. Chair
Department of Pathology & Immunology
Baylor College of Medicine
Director
Clinical Chemistry
Ben Taub Hospital
Member
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

BA from University Of Chicago (with Honors)
MD-PhD from Washington University School of Medicine

Certifications

Clinical Pathology Resident
Hospital of the University of Pennsylvania (1990-1991)
Pathology Resident and Postdoctoral Fellow
Baylor College of Medicine (1991-1993)
Diplomate
The American Board of Pathology in Clinical Pathology (2006)

Professional Interests

  • Chemical biology and drug discovery
  • Mammalian reproduction
  • TGF-beta and cell signaling networks in female reproduction
  • Ovarian cancer
  • Germ cell biology, spermatogenesis, and infertility
  • Male contraception
  • Oncogenesis, reproduction, and development in mice

Professional Statement

Over the last 25 years, our research program has focused on the identification and functional analysis of genes and pathways involved in mammalian reproduction. In many cases, we have taken a discovery-based approach to first uncover novel genes expressed exclusively in the male or female germlines and then to define their roles in vivo, using transgenic models. In the process, we have identified novel genes involved in oocyte-somatic cell interactions during ovarian folliculogenesis (e.g., GDF9 and BMP15), oocyte-to-embryo transition (e.g., ZAR1 and NPM2), germ-cell intercellular bridge formation (e.g., TEX14), the piRNA pathway (e.g., GASZ), etc. Infertility in male mice lacking a specific gene would also indicate that the gene product is a promising and novel target for contraception in men. Indeed, we have begun to characterize small-molecule contraceptives in vivo. We have also created new models by which to study ovarian cancer and to decipher the crosstalk of TGF-beta superfamily (e.g., activin, inhibin, BMP, and GDF), hormonal (e.g., FSH and LH), and small RNA (e.g., DICER and GASZ) signaling pathways in normal and diseased reproductive tissues.

Selected Publications