Positions
- Associate Professor
-
Molecular & Cellular Biology
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- BCM-Margaret Alkek Biomedical Research Building (Office)
-
Room: ABBR R509
Houston, TX 77030
United States
Phone: (713) 798-5485
kc1@bcm.edu
Education
- Ph.D. from University Of Texas MD Anderson Cancer Center
- 01/2004 - Houston, TX United States
- Post-Doctoral Fellowship at Stanford University
- 01/2009 - Stanford, California United States
Honors & Awards
- Scientific Mentor-in-training, AACR Scientist <-> Survivor (Advocacy) Program
- American Association for Cancer Research (04/2016 - 04/2016)
- V Scholar Award
- V Foundation for Cancer Research (09/2011 - 10/2013)
- Erasmus Lecturer on Cancer Stem Cells
- Netherlands (04/2012 - 04/2012)
- Howard Temin K99/R00 Pathway-to-Independence Award
- National Cancer Institute (01/2007 - 01/2012)
- Dan L Duncan Career Development Award
- 01/2009
- David Packard Urology Postdoctoral Fellow Award
- 05/2008 - 04/2009
- Oncology Scholar-in-Training Award
- AACR-Bristol-Myers Squibb (01/2008)
- Gerald P. Murphy Scholar
- American Urological Association (01/2007)
- Shell Oil Foundation Scholarship
- UT Graduate School of Biomedical Sciences (09/2003 - 08/2004)
Professional Interests
- Cancer Stem Cells and Tumoral Heterogeneity; Extracellular matrix and Immune Microenvironment; Cancer Therapeutics
Websites
VIICTR Research Database
Selected Publications
- Mo Q, Nikolos F, Chen F, Tramel Z, Lee YC, Hayashi K, Xiao J, Shen J, and Chan KS "Prognostic power of a tumor differentiation gene signature for bladder urothelial carcinoma." Journal of the National Cancer Institute JNCI. 2018 Jan 12;110(5):djx243.
- Rodriguez-Brenes IA, Kurtova A, Lin C, Lee YC, Xiao J, Mims M, Chan KS*, Wodarz D* (* = Co-corresponding authors) "Cellular hierarchy as a determinant of tumor sensitivity to chemotherapy." Cancer Research. 2017;77(9):2231-2241.
- Chan, KS "Targeting cancer stem cells awakened by chemotherapy to abrogate tumor repopulation." Clinical Cancer Research. 2016 Feb 15;22(4):802-6.
- Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner S, Chen F, Roh T, Lay E, Ho PL & Chan KS "Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance." Nature. 2015 Jan 8;517(7533):209-13.
- Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR. "RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation.." Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):17389-94.
- Volkmer JP, Sahoo D, Chin RK, Ho PL, Tang C, Kurtova AV, Willingham SB, Pazhanisamy SK, Contreras-Trujillo H, Storm TA, Lotan Y, Beck AH, Chung BI, Alizadeh AA, Godoy G, Lerner SP, van de Rijn M, Shortliffe LD, Weissman IL, Chan KS "Three differentiation states risk-stratify bladder cancer into distinct subtypes.." Proc. Natl. Acad. Sci. U.S.A.. 2012 Feb 7;109(6):2078-83. Pubmed PMID: 22308455
- Ho PL, Kurtova A, Chan KS "Normal and neoplastic urothelial stem cells: getting to the root of the problem.." Nat Rev Urol. 2012 Oct;9(10):583-94. Pubmed PMID: 22890301
- Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL "Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells.." Proc. Natl. Acad. Sci. U.S.A.. 2009 Aug 18;106(33):14016-21. Pubmed PMID: 19666525
- Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, DiGiovanni J "Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.." J. Clin. Invest.. 2004 Sep;114(5):720-8. Pubmed PMID: 15343391
- Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J "Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model.." Nat. Med.. 2005 Jan;11(1):43-9. Pubmed PMID: 15592573
Skills
- Research Interests
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