Positions

Associate Professor
Department of Neuroscience
Baylor College of Medicine
Houston, TX, US

Education

Postdoctoral Training at Gladstone Institute of Neurological Disease and UCSF
Alzheimer's disease
PhD from University of Texas Graduate School of Biomedical Sciences
Neuroscience
BA from University of Texas, Austin
Zoology
BS from University of Texas, Austin
Biology

Professional Interests

  • Mechanisms of cognitive dysfunction in Alzheimer's disease, epilepsy, and other neurological disorders
  • Activity-dependent epigenetic regulation of gene expression
  • Neural stem cell dynamics
  • Corticothalamic network (dys)function in neurological disease

Professional Statement

The focus of our research is to understand the cellular and network mechanisms underlying cognitive impairments in Alzheimer’s disease (AD) and other neurological disorders, and to identify therapeutic entry points for the treatment of these devastating diseases. We use a multi-disciplinary approach that combines biochemistry, molecular biology, in vivo physiology, and behavioral paradigms to link cellular alterations to memory deficits in mouse models of AD. We use video-recorded EEG to characterize patterns of (aberrant) brain activity in individual mice and correlate activity with performance in behavioral paradigms that test different aspects of memory and cognition. Finally, we use biochemical, molecular, and viral expression techniques to identify links between particular genes and cognitive dysfunction on a mouse-by-mouse basis. This integrated approach allows us to investigate the molecular basis of memory impairments in AD and identify therapeutic entry points for the treatment of this neurodegenerative disease.