Associate Professor and Vivian L. Smith Endowed Chair in Neuroscience
Department of Neuroscience
Baylor College of Medicine
Houston, TX 77030


Postdoctoral Fellowship at UCSF, San Francisco
PhD from University of Texas, Houston
BS from Drexel University, Philadelphia
BS from Drexel University, Philadelphia

Professional Interests

  • Neural Circuits
  • Computational Neuroscience
  • Prediction Machines
  • Supervised Learning

Professional Statement

My laboratory investigates how neural circuits make predictions. Our goal is to answer two questions about the computational algorithms implemented in the brain: (1) how is information about the past used to predict the future, (2) how are error signals used to update and improve these predictions. To provide mechanistic answers to these difficult questions, we study the function of neural circuits in mice trained to predict future events. Our experimental approach allows us to visualize and perturb the activity of cell-specific neuron populations with millisecond precision, by taking advantage of powerful new tools in electrophysiology, two-photon imaging and optogenetics. In addition, we build large-scale computer models and use machine learning to reveal general computational principles, refine our hypotheses and suggest novel research directions. Our work has implications for understanding and treating a number of motor and cognitive brain disorders that have been linked to deficits in prediction.

Selected Publications