Positions

Dir, Trop Med Rsrch
Pediatrics-Tropical Medicine
Baylor College of Medicine
Houston, TX, US

Education

BA from University of Northern Colorado

Selected Publications

  • Wang Q, Tan MT, Keegan BP, Barry MA, Heffernan MJ. "Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation." Biomaterials. 2014 September;35(29):8385-8393.
  • Brelsford JB, Plieskatt JL, Yakovleva A, Jariwala A, Keegan BP, Peng J, Xia P, Li G, Campbell D, Periago MV, Correa-Oliveira R, Bottazzi ME, Hotez PJ, Diemert D, Bethony JM. "Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine." PLoS Negl Trop Dis. 2017 February 13;11(2)
  • McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Arjona-Sabido R, Cruz-Chan V, Dumonteil E, Hotez PJ, Bottazzi ME. "Expression, purification, immunogenicity and protective efficacy of a recombinant nu-cleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cuta-neous leishmaniasis." Protein Expr Purif. 2017 February;130
  • Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. "Cysteine Mutagenesis Improves the Production without Abrogating Antigenicity of a Re-combinant Protein Vaccine Candidate for Human Chagas Disease." Hum Vaccin Immunother. 2016 October 13
  • Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. "A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease." Hum Vaccin Immunother. 2016 April 2;12(4)
  • Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A. "New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74." Hum Vaccin Immunother. 2015 May 4;11(5)
  • Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. "Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections." Expert Rev Vaccines. 2014 March;13(3)
  • Hu Y, Zhan B, Keegan B, Yiu Y, Miller M, Jones K, Aroian R. "Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms." PLOS Neglected Tropical Diseases. 2012;6(11)
  • Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, De Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. "Fusion of Na-ASP-2 with human immunoglobulin Fcγ abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE." Parasite Immunology. 2012 August;34(8-9)
  • Mathias DK, Plieskatt JL, Armistead JS, Bethony JM, Abdul-Majid KB, McMillan A, Angov E, Aryee MJ, Zhan B, Gillespie P, Keegan B, Jariwala AR, Rezende W, Bottazzi ME, Scorpio DG, Hotez PJ, Dinglasan RR. "Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine." Infection and Immunity. 2012 February 6
  • Nair SS, Bommana A, Bethony JM, Lyon AJ, Ohshiro K, Pakala SB, Rinaldi G, Keegan B, Suttiprapa S, Periago MV, Hotez PJ, Brindley PJ, Kumar R. "The Metastasis-associated gene 1 encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer." Hepatology. 2011 July;54(1)
  • Jiang D, Zhan B, Mayor RS, Gillespie P, Keegan B, Bottazzi ME, Hotez P. "Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum." Molecular and Biochemical Parasitology. 2011 January 18
  • Jariwala AR, Periago MV, Oliveira LM, Diemert DJ, Keegan B, Plieskatt JL, Bottazzi ME, Hotez PJ, Bethony JM. "Potency testing for the experimental Na-GST-1 hookworm vaccine." Expert Reviews Vaccine. 2010;9(10)
  • Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A. "An enzymatically inactivated hemoglobinase from Necator americanus induces neutral-izing antibodies against multiple hookworm species and protects dogs against heterolo-gous hookworm infection." FASEB J. 2009 April 20
  • Singh S, Miura K, Zhou H, Muratova O, Keegan B, Miles A, Martin LB, Saul AJ, Miller LH, Long CA. "Immunity to recombinant Plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity. Infection and Immunity." Infection and Immunity. 2006;74(8)
  • Makobongo MO, Keegan B, Long CA, Miller LH. "Immunization of Aotus monkeys with recombinant cysteine-rich interdomain region 1 alpha protects against severe disease during Plasmodium falciparum reinfection." Journal of Infectious Diseases. 2006;193(5)
  • Stowers AW, Kennedy MC, Keegan BP, Saul A, Long CA, Miller LH. "Vaccination of monkeys with Plasmodium falciparum apical membrane antigen 1 con-fers protection against blood stage malaria.." Infection and Immunity. 2002;70