Changyi Johnny Chen, M.D., Ph.D.
- Alkek Building for Biomedical Research (Lab)
- One Baylor Plaza R413 Mail Stop: BCM391 Houston, Texas 77021 United States Division of Surgical Research
- Professor of Surgery and Chief
- Division of Surgical Research
- Baylor College of Medicine
- Molecular Surgery Endowed Chair
- Baylor College of Medicine
- Director, Molecular Surgeon Research Center
- Molecular Surgeon Research Center
- Molecular and Cellular Biology
- Baylor College of Medicine
- Ph.D. from Georgia Institute Of Technology
- Postdoctoral training from Emory University School Of Medicine
- M.S. from University Of Texas At El Paso
- Clinical residency training from Southeast University School Of Medicine - Zhong-Da Hospital
- M.D. from Southeast University School Of Medicine
- Pancreatic cancer
- PLGA-PEI based nanotechnology
- Endothelial dysfunction and vascular disease
- Cardiovascular disease
- Endothelial nitric oxide synthase
- Oxidative stress and antioxidants
- Vascular tissue engineering
Dr. Chen's laboratory is actively conducting several basic science and translational research projects that are highly relevant to clinical cardiovascular disease and pancreatic cancer.
Cardiovascular risk factors and their molecular mechanisms in cardiovascular disease:
We are investigating the effects and the molecular mechanisms of several cardiovascular risk factors, including HIV protease inhibitors, the adipokine resistin, soluble CD40L, and uric acid, on biochemical pathways associated with endothelial cell functions. Some of the biochemical pathways under investigation are the endothelial nitric oxide synthase system, the oxidative stress system, and signal transduction pathways. We are carrying on these investigations using several experimental models, such as myographies, organ cultures, mouse models, human tissue samples, and different types of endothelial cells. Based on the molecular mechanisms we uncover, we develop effective therapeutic strategies to treat endothelial dysfunction and atherosclerosis.
Endothelial cell differentiation and angiogenesis:
We are studying the role played by and the molecular mechanisms of hemodynamic factors and several novel molecules on endothelial cells differentiated from embryonic stem cells and from bone marrow-derived stem cells. We are identifying key regulatory genes that trigger endothelial cell differentiation and promote stable angiogenesis. These findings can potentially be applied to the design of novel therapeutic strategies to treat ischemic tissues using genetically engineered endothelial cells. In addition, these studies may provide useful information to genetically engineer novel tissues for vascular grafts.
We have been heavily involved in pancreatic cancer research programs for many years. We have several projects focusing on the role and on the mechanisms of several genes, such as microRNA 196a (miR-196a), X-inactive specific transcript (XIST), and Jude-2 in pancreatic cancer. Our comprehensive studies analyze human cancer specimens, clinical outcomes, established cell lines, a nude mouse model, and a genetically engineered mouse model of pancreatic cancer called the KPC model. We are developing PLGA [poly(lactic-co-glycolic acid)]-based nanotechnology for molecular imaging and for specific drug and gene delivery, which has great potential clinical applications, such as molecular diagnostics and targeted therapies.
- Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. "Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system.." J. Surg. Res.. 2006 June 15;133(2):143-9. Pubmed PMID: 16360172
- Conklin BS, Zhong DS, Zhao W, Lin PH, Chen C. "Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells.." J. Surg. Res.. 2002 January;102(1):13-21. Pubmed PMID: 11792146
- Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C. "TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells.." J. Surg. Res.. 2005 February;123(2):294-301. Pubmed PMID: 15680393
- Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q. "Somatostatin, somatostatin receptors, and pancreatic cancer.." World J Surg. 2005 March;29(3):293-6. Pubmed PMID: 15706439
- Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. "Review: application of stem cells for vascular tissue engineering.." Tissue Eng.. 11(41527):1535-52. Pubmed PMID: 16259608
- Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C. "Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors.." Cancer. 2004 November 15;101(10):2341-50. Pubmed PMID: 15476280
- Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ. "Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease.." Med. Sci. Monit.. 2004 August;10(8):RA187-92. Pubmed PMID: 15278009
- Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC. "Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice.." World J Surg. 2005 March;29(3):339-43. Pubmed PMID: 15706434
- Lin PH, Martin L, Matsuura JH, Wellons E, Bush RL, Terramani TT, Chen C, Lumsden AB. "Intraaortic stabilization of the AneuRx stent-graft system: a useful adjunct to minimize device migration.." Cardiovasc Intervent Radiol. 26(1):73-5. Pubmed PMID: 12491021
- Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y. "In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences.." Blood. 1995 October 1;86(7):2708-14. Pubmed PMID: 7670109