Positions

Caroline Wiess Law Scholar, Assistant Professor
Molecular and Human Genetics, Molecular and Cellular Biology
Baylor College of Medicine
Houston, TX
Attending Physician
Pediatric Genetics Clinic
Texas Children's Hospital
Houston, TX

Education

MD from MIMER Medical College
PhD from Baylor College of Medicine
Molecular and Cellular Biology
Internship at Baylor College of Medicine
Medicine/Pediatrics
Residency at Baylor College of Medicine
Medical Genetics

Certifications

Clinical Genetics
American Board of Medical Genetics and Genomics

Professional Interests

  • Energy and metabolic homeostasis, asprosin biology, identification of novel disorders of energy balance in humans

Professional Statement

I am a physician-scientist at Baylor College of Medicine with clinical expertise in Medical Genetics and research expertise in the field of energy homeostasis and metabolic disease. Through the assessment of humans with genetic defects in the processing of energy, we are able to identify new genes and pathways that have escaped attention so far. This not only benefits patients but also allows us to take the discovery into the lab and focus on filling in the gap from the gene to the phenotype. The overarching aim is to help one patient at a time but also a broader swath of humanity via advancing medical knowledge and developing novel therapeutics. As an example of this, by studying a rare genetic disorder - Neonatal Progeroid Syndrome, our lab was the first to identify a novel hormone (that we named asprosin) that enables hepatic glucose production to meet the needs of the organism when dietary glucose is unavailable. In the therapeutic arena, antibodies targeting asprosin are showing considerable promise in the treatment of diabetes and insulin resistance by acutely resulting in reduced blood glucose and insulin levels.

Selected Publications

Funding

Caroline Wiess Law Scholar Award for Academic Excellence
Unrestricted funding from The Caroline Wiess Law Endowment
Chao Physician-Scientist Award
Unrestricted funding from The Ting Tsung and Wei Fong Chao Foundation
Clinical Scientist Development Award (K08)
- #1K08DK102529
Grant funding from The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)