Todd Rosengart, M.D., F.A.C.S.
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Todd Rosengart, M.D., F.A.C.S.
Professor and Chair, Department of Surgery
Positions
- Professor and Chair, Department of Surgery
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Baylor College of Medicine
- DeBakey-Bard Chair of Surgery
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Baylor College of Medicine
- Professor of Molecular and Cellular Biology
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Baylor College of Medicine
- Professor of Heart and Vascular Disease
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Texas Heart Institute
Addresses
- Baylor Medicine at McNair Campus (Clinic)
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7200 Cambridge Street
6th Floor
Houston, TX 77030
United States
(713) 798-8504
Education
- Clinical Fellowship at The New York Hospital
- New York
- Thoracic Surgery
- Research Fellowship at National Institutes of Health
- 01/1987 - Bethesda, MD United States
- Residency at New York University Medical Center
- 01/1989 - New York, New York United States
- General Surgery
- Internship at New York University Medical Center
- 01/1985 - New York, NY United States
- General Surgery
- MD from Northwestern University
- 01/1983 - Chicago, IL United States
Certifications
- Board Certified
- American Board of Surgery
- Board Certified
- American Board of Thoracic Surgery
Honors & Awards
- Texas “Super Doctor”
- Texas Monthly
- Top Doctors
- 2013 – 2020
- Houstonian Magazine
- Top Doctors
- 2004-2006
- Chicago Magazine
- Top Doctors
- 2007-2012
- New York Magazine
- America’s Top Doctors
- 3rd – 11th Edition
- Castle Connolly
- Distinguished Scientist Award
- 2017
- Baylor St. Luke’s Medical Center
Professional Interests
- Cardiothoracic Surgery
- Minimally Invasive Heart Surgery
- Off-pump Surgery
- Coronary Artery Bypass Surgery
- Minimally invasive Aortic or Mitral Repair or Replacement
- Minimally Invasive Valve Surgery
Professional Statement
Dr. Todd K. Rosengart, Chair and DeBakey-Bard Chair of Surgery, is a National Institutes of Health (NIH)-supported scientist with uninterrupted extramural funding since 1998. An extensively published investigator, he is also editor of Seminars in Thoracic and Cardiovascular Surgery and immediate past chair of the NIH Bioengineering, Technology, and Surgical Sciences (BTSS) study section. He is also immediate past president of the Society of Surgical Chairs, representing the academic chairs of surgery in North America, and is a member of the board of directors of the American Association for Thoracic Surgery.Basic and translational research have occupied a predominant position in Dr. Rosengart’s academic career beginning with his serving as a Clinical Fellow at the NIH, and continuing with appointments as an independent investigator with American Heart Association sponsored research support. Dr. Rosengart continues to run an NIH-funded laboratory with over 20 years of NIH support in the fields of angiogenesis and cellular reprogramming. This effort has been highlighted by his role in the bench-to-bedside development of angiogenic therapy as a potential treatment for atherosclerotic coronary artery and vascular occlusive disease, and his lab’s current, multi-year focus to study cardiac cellular reprogramming. He is PI of a cardiovascular surgery NIH T32 training grant and recipient of nearly $20 million in total research grants. He is chair of the American Heart Association Surgery Science Study Section, and a member of the Scientific Advisory Committee for the Leducq Foundation.
Dr. Rosengart’s research includes his translation of early in vivo examinations of angiogenic growth factors beginning in the mid-1980s In 1997, he and his team at Cornell performed the world’s first viral-based cardiac gene transfer procedure, part of a landmark NIH and FDA-approved first-in-man Phase I/II angiogenesis trial using vascular endothelial growth factor (VEGF) to treat “no option” patients with end stage coronary artery disease. His current NIH-funded research is exploring the use of cardiogenic reprogramming transcription factors to induce in situ “cardio-differentiation” of myocardial scar fibroblasts as a myocardial regeneration strategy for the treatment of myocardial infarction. These current investigations of cellular reprogramming offer the exciting possibility of “bio-interventions” for the treatment of hundreds of thousands with advanced heart disease still not treatable by conventional therapies.
Dr. Rosengart’s institutional roles include his serving as chair of the BCM Faculty Group Practice Board of Governors, and as a member of the Baylor St. Luke’s Medical Center Board of Directors. He recently served as board chair of the Affiliated Medical Services, which represented the consortium of BCM and University of Texas faculty staffing the HarrisHealth county medical system. He also served as national chair of the cardiac surgery service line for CHI (now Common Spirit), our 140-hospital national hospital network.
As a physician-entrepreneur, Dr. Rosengart was a co-founder of Vitals.com (MDx, LLC), a a leading health provider search and physician/patient interface website with over 13 million monthly visits, and is also co-founder of XyloCor Therapeutics, which holds FDA “Fast Track” designation for a current Phase I/II testing of a novel cardiac gene therapy prototype for treating patients with end stage coronary artery disease. He holds twelve patents, including those for a method of inducing angiogenesis.
Websites
Cardiothoracic Surgery
Follow Dr. Rosengart on Twitter
Videos
Dr. Todd K. Rosengart discusses building a team of experts to carry on the legacy of Baylor College of Medicine's storied Michael E. DeBakey Department of Surgery.
Selected Publications
- Suliburk JW, Buck QM, Pirko CJ, Massarweh NN, Barshes NR, Singh H, Rosengart TK "Analysis of human performance deficiencies associated with surgical adverse events." JAMA Netw Open. 2019 : Pubmed PMID: 3136510
- Rosengart TK, Doherty G, Higgins R, Kibbe MR, Mosenthal AC "Transition Planning for the Senior Surgeon: Guidance and Recommendations From the Society of Surgical Chairs." JAMA Surg. : Pubmed PMID: 31090889
- LeMaire SA, Trautner BW, Ramamurthy U, Green SY, Zhang Q, Fisher WE, Rosengart TK "An academic relative value unit system for incentivizing the academic productivity of surgery faculty members." Ann Surg. 2018 : Pubmed PMID: 30004925
- Patel V, Cooney A, Flores ER, Singh V, Mathison M, Sanagasetti, D, Mullany LK, Crystal RG, Yang J, Rosengart TK "p63 silencing enhances the reprogramming of cardiac fibroblasts into induced cardiomyocytes." J Thorac Cardiovasc Surg. 2018 : Pubmed PMID: 29716728
- Mathison M, Singh VP, Sanagasetti D, Yang L, Pinnamaneni JP, Yang J, Rosengart TK "Cardiac reprogramming factor Gata4 reduces post-infarct cardiac fibrosis through direct repression of the pro-fibrotic mediator snail." J Thorac Cardiovasc Surg. 2017 : Pubmed PMID: 28711329
- Rosengart TK, Mason MC, LeMaire SA, Brandt ML, Coselli JS, Curley SA, Mattox KL, Mills JL, Sugarbaker DJ, Berger DA "The seven attributes of the academic surgeon: critical aspects of the archetype and contributions to the surgical community." Am J Surg. 2017 : Pubmed PMID: 28284432
- Rosengart TK, Kent KC, Bland KI, Britt LD, Eberlein TJ, Gewertz BL, Hunter JG, Lillemoe KD, Pellegrini CA, Schulick RD, Stain SC, Weigel RJ "Key tenets of effective surgery leadership: perspectives from the Society of Surgical Chairs mentorship sessions." JAMA Surgery. 2016 : Pubmed PMID: 27096328
- Rosengart TK "The 1000th VAD, the great rivalry, and the grand experiment of the Texas Medical Center.." Semin Thorac Cardiovasc Surg. 2014 : Pubmed PMID: 24952751
- Rosengart TK, Romeiser JL, White LJ, Fratello A, Fallon E, Senzel L, Shroyer AL "Platelet activity measured by a rapid turnaround assay identifies coronary artery bypass grafting patients at increased risk for bleeding and transfusion complications after clopidogrel administration." J Thorac Cardiovasc Surg. : Pubmed PMID: 23953984
- Price JD, Romeiser JL, Gnerre JM, Shroyer AL, Rosengart TK "Risk analysis for readmission after coronary artery bypass surgery: developing a strategy to reduce readmissions.." J. Am. Coll. Surg.. 2013 March ; 216 (3): 412-9. Pubmed PMID: 23313544
- Rosengart TK, Sweet J, Finnin EB, Wolfe P, Cashy J, Hahn E, Marymont J, Sanborn T "Neurocognitive functioning in patients undergoing coronary artery bypass graft surgery or percutaneous coronary intervention: evidence of impairment before intervention compared with normal controls.." Ann. Thorac. Surg.. 2005 October ; 80 (4): 1327-34; discus. Pubmed PMID: 16181864
- Rosengart TK, DeBois W, O'Hara M, Helm R, Gomez M, Lang SJ, Altorki N, Ko W, Hartman GS, Isom OW, Krieger KH "Retrograde autologous priming for cardiopulmonary bypass: a safe and effective means of decreasing hemodilution and transfusion requirements.." J. Thorac. Cardiovasc. Surg.. 1998 February ; 115 (2): 426-38; discuss. Pubmed PMID: 9475538
- Rosengart TK, Helm RE, DeBois WJ, Garcia N, Krieger KH, Isom OW "Open heart operations without transfusion using a multimodality blood conservation strategy in 50 Jehovah's Witness patients: implications for a bloodless" surgical technique."." J. Am. Coll. Surg.. 1997 June ; 184 (6): 618-29. Pubmed PMID: 9179119
- Rosengart TK, Krieger K, Lang SJ, Gold JP, Altorki N, Roussel M, Debois WJ, Isom OW "Reoperative coronary artery bypass surgery. Improved preservation of myocardial function with retrograde cardioplegia.." Circulation. 1993 November ; 88 (5): II330-5. Pubmed PMID: 8222174
- Rosengart TK, Bishawi MM, Halbreiner MS, Fakhoury M, Finnin E, Hollmann C, Shroyer AL, Crystal RG "Long-Term Follow-Up Assessment of a Phase 1 Trial of Angiogenic Gene Therapy Using Direct Intramyocardial Administration of an Adenoviral Vector Expressing the VEGF121 cDNA for the Treatment of Diffuse Coronary Artery Disease.." Hum. Gene Ther.. 2013 February ; 24 (2): 203-8. Pubmed PMID: 23137122
- Rosengart TK, Lee LY, Patel SR, Kligfield PD, Okin PM, Hackett NR, Isom OW, Crystal RG "Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA.." Ann. Surg.. 1999 October ; 230 (4): 466-70; discuss. Pubmed PMID: 10522716
- Mack CA, Patel SR, Schwarz EA, Zanzonico P, Hahn RT, Ilercil A, Devereux RB, Goldsmith SJ, Christian TF, Sanborn TA, Kovesdi I, Hackett N, Isom OW, Crystal RG, Rosengart TK "Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart.." J. Thorac. Cardiovasc. Surg.. 1998 January ; 115 (1): 168-76; discuss. Pubmed PMID: 9451061
- Mathison M, P Gersch R, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK "In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor.." J Am Heart Assoc. 2012 December ; 1 (6): e005652. Pubmed PMID: 23316332
- Rosengart TK, Lee LY, Patel SR, Sanborn TA, Parikh M, Bergman GW, Hachamovitch R, Szulc M, Kligfield PD, Okin PM, Hahn RT, Devereux RB, Post MR, Hackett NR, Foster T, Grasso TM, Lesser ML, Isom OW, Crystal RG "Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease.." Circulation. 1999 August 3; 100 (5): 468-74. Pubmed PMID: 10430759
- Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK ""Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors.." . J Thorac Cardiovasc Surg. : Pubmed PMID: 24755332
- Dathatri S, Gruberg L, Anand J, Romeiser J, Sharma S, Finnin E, Shroyer AL, Rosengart TK "Informed consent for cardiac procedures: deficiencies in patient comprehension with current methods." Ann Thorac Surg. : Pubmed PMID: 24629303
- Omer S, Cornwell LD, Rosengart TK, Kelly RF, Ward HB, Holman WL, Bakaeen FG "Completeness of coronary revascularization and survival: Impact of age and off-pump surgery." J Thorac Cardiovasc Surg. : Pubmed PMID: 24521971
- Fourman MS, Gersch RP, Phillips BT, Nasser A, Rivara A, Verma R, Dagum AB, Rosengart TK, Bui DT "Comparison of Laser Doppler and Laser-Assisted Indocyanine Green Angiography Prediction of Flap Survival in a Novel Modification of the McFarlane Flap." Ann Plast Surg. : Pubmed PMID: 24401807
- Rosengart TK "Cardiac cellular reprogramming." Tex Heart Inst J. : Pubmed PMID: 24391328
- Kaminsky SM, Rosengart TK, Rosenberg J, Chiuchiolo MJ, Van de Graaf B, Sondhi D, Crystal RG "Gene therapy to stimulate angiogenesis to treat diffuse coronary artery disease." Hum Gene Ther. : Pubmed PMID: 24164242
- Patel SR, Lee LY, Mack CA, Polce DR, El-Sawy T, Hackett NR, Ilercil A, Jones EC, Hahn RT, Isom OW, Rosengart TK, Crystal RG "Safety of direct myocardial administration of an adenovirus vector encoding vascular endothelial growth factor 121.." Hum. Gene Ther.. 1999 May 20; 10 (8): 1331-48. Pubmed PMID: 10365664
- Ferraris VA, Saha SP, Oestreich JH, Song HK, Rosengart T, Reece TB, Mazer CD, Bridges CR, Despotis GJ, Jointer K, Clough ER "2012 update to the society of thoracic surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations.." Ann. Thorac. Surg.. 2012 November ; 94 (5): 1761-81. Pubmed PMID: 23098967
- Levy JH, Pifarre R, Schaff HV, Horrow JC, Albus R, Spiess B, Rosengart TK, Murray J, Clark RE, Smith P "A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting.." Circulation. 1995 October 15; 92 (8): 2236-44. Pubmed PMID: 7554207
- Rosengart TK, Coppa GF "Abdominal mycobacterial infections in immunocompromised patients.." Am. J. Surg.. 1990 January ; 159 (1): 125-31. Pubmed PMID: 2294789
- Sweet JJ, Finnin E, Wolfe PL, Beaumont JL, Hahn E, Marymont J, Sanborn T, Rosengart TK "Absence of cognitive decline one year after coronary bypass surgery: comparison to nonsurgical and healthy controls.." Ann. Thorac. Surg.. 2008 May ; 85 (5): 1571-8. Pubmed PMID: 18442540
- Schalch P, Rahman GF, Patejunas G, Goldschmidt RA, Carbray J, Retuerto MA, Kim D, Esser K, Crystal RG, Rosengart TK "Adenoviral-mediated transfer of vascular endothelial growth factor 121 cDNA enhances myocardial perfusion and exercise performance in the nonischemic state.." J. Thorac. Cardiovasc. Surg.. 2004 February ; 127 (2): 535-40. Pubmed PMID: 14762365
- Whitlock PR, Hackett NR, Leopold PL, Rosengart TK, Crystal RG "Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs.." Mol. Ther.. 2004 January ; 9 (1): 67-75. Pubmed PMID: 14741779
- Amano H, Hackett NR, Kaner RJ, Whitlock P, Rosengart TK, Crystal RG "Alteration of splicing signals in a genomic/cDNA hybrid VEGF gene to modify the ratio of expressed VEGF isoforms enhances safety of angiogenic gene therapy.." Mol. Ther.. 2005 October ; 12 (4): 716-24. Pubmed PMID: 16039163
- Kupferschmid JP, Rosengart TK, McIntosh CL, Leon MB, Clark RE "Amiodarone-induced complications after cardiac operation for obstructive hypertrophic cardiomyopathy.." Ann. Thorac. Surg.. 1989 September ; 48 (3): 359-64. Pubmed PMID: 2774719
- Sarateanu CS, Retuerto MA, Beckmann JT, McGregor L, Carbray J, Patejunas G, Nayak L, Milbrandt J, Rosengart TK "An Egr-1 master switch for arteriogenesis: studies in Egr-1 homozygous negative and wild-type animals.." J. Thorac. Cardiovasc. Surg.. 2006 January ; 131 (1): 138-45. Pubmed PMID: 16399305
- Crystal RG, Harvey BG, Wisnivesky JP, O'Donoghue KA, Chu KW, Maroni J, Muscat JC, Pippo AL, Wright CE, Kaner RJ, Leopold PL, Kessler PD, Rasmussen HS, Rosengart TK, Hollmann C "Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions.." Hum. Gene Ther.. 2002 January 1; 13 (1): 65-100. Pubmed PMID: 11779413
- Retuerto MA, Schalch P, Patejunas G, Carbray J, Liu N, Esser K, Crystal RG, Rosengart TK "Angiogenic pretreatment improves the efficacy of cellular cardiomyoplasty performed with fetal cardiomyocyte implantation.." J. Thorac. Cardiovasc. Surg.. 2004 April ; 127 (4): 1041-9; discuss. Pubmed PMID: 15052201
- Retuerto MA, Beckmann JT, Carbray J, Patejunas G, Sarateanu S, Kane BJ, Smulevitz B, McPherson DD, Rosengart TK "Angiogenic pretreatment to enhance myocardial function after cellular cardiomyoplasty with skeletal myoblasts.." J. Thorac. Cardiovasc. Surg.. 2007 February ; 133 (2): 478-484.e2. Pubmed PMID: 17258586
- Rosengart TK "Anticoagulation self-testing after heart valve replacement.." J. Heart Valve Dis.. 2002 January ; 11 : S61-5. Pubmed PMID: 11843523
- Rajamannan NM, Nealis TB, Subramaniam M, Pandya S, Stock SR, Ignatiev CI, Sebo TJ, Rosengart TK, Edwards WD, McCarthy PM, Bonow RO, Spelsberg TC "Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation.." Circulation. 2005 June 21; 111 (24): 3296-301. Pubmed PMID: 15956138
- Hamawy AH, Lee LY, Crystal RG, Rosengart TK "Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization.." Curr. Opin. Cardiol.. 1999 November ; 14 (6): 515-22. Pubmed PMID: 10579070
- Rosengart TK, Fallon E, Crystal RG "Cardiac biointerventions: whatever happened to stem cell and gene therapy?." Innovations (Phila). 2012 May ; 7 (3): 173-9. Pubmed PMID: 22885457
- Klemperer JD, Ko W, Krieger KH, Connolly M, Rosengart TK, Altorki NK, Lang S, Isom OW "Cardiac operations in patients with cirrhosis.." Ann. Thorac. Surg.. 1998 January ; 65 (1): 85-7. Pubmed PMID: 9456100
- Mack CA, Magovern CJ, Hahn RT, Sanborn T, Lanning L, Ko W, Isom OW, Rosengart TK "Channel patency and neovascularization after transmyocardial revascularization using an excimer laser: results and comparisons to nonlased channels.." Circulation. 1997 November 4; 96 (9): II-65-9. Pubmed PMID: 9386077
- Mack CA, Song WR, Carpenter H, Wickham TJ, Kovesdi I, Harvey BG, Magovern CJ, Isom OW, Rosengart T, Falck-Pedersen E, Hackett NR, Crystal RG, Mastrangeli A "Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype.." Hum. Gene Ther.. 1997 January 1; 8 (1): 99-109. Pubmed PMID: 8989999
- Simons M, Bonow RO, Chronos NA, Cohen DJ, Giordano FJ, Hammond HK, Laham RJ, Li W, Pike M, Sellke FW, Stegmann TJ, Udelson JE, Rosengart TK "Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary.." Circulation. 2000 September 12; 102 (11): E73-86. Pubmed PMID: 10982554
- Rosengart TK "Cognitive decline and ischemic microlesions after coronary catheterization: A comparison to coronary artery bypass.." Am. Heart J.. 2012 April ; 163 (4): e13. Pubmed PMID: 22520544
- Rosengart TK, Helm RE, Klemperer J, Krieger KH, Isom OW "Combined aprotinin and erythropoietin use for blood conservation: results with Jehovah's Witnesses.." Ann. Thorac. Surg.. 1994 November ; 58 (5): 1397-403. Pubmed PMID: 7526810
- Helm RE, Rosengart TK, Gomez M, Klemperer JD, DeBois WJ, Velasco F, Gold JP, Altorki NK, Lang S, Thomas S, Isom OW, Krieger KH "Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion.." Ann. Thorac. Surg.. 1998 January ; 65 (1): 125-36. Pubmed PMID: 9456106
- Velasco FT, Ko W, Rosengart T, Altorki N, Lang S, Gold JP, Krieger KH, Isom OW "Cost containment in cardiac surgery: results with a critical pathway for coronary bypass surgery at the New York hospital-Cornell Medical Center.." Best Pract Benchmarking Healthc. 1 (1): 21-8. Pubmed PMID: 9192587
- Magovern CJ, Mack CA, Zhang J, Hahn RT, Ko W, Isom OW, Crystal RG, Rosengart TK "Direct in vivo gene transfer to canine myocardium using a replication-deficient adenovirus vector.." Ann. Thorac. Surg.. 1996 August ; 62 (2): 425-33; discuss. Pubmed PMID: 8694601
- Crystal RG, Kaminsky SM, Hackett NR, Rosengart TK "Double-blinded, placebo-controlled, randomized gene therapy using surgery for vector delivery.." Hum. Gene Ther.. 2012 May ; 23 (5): 438-41. Pubmed PMID: 22452798
- Zhang QX, Duenas M, Rosengart T "Effect of tumor necrosis factor-alpha on a cell line transformed by a secreted form of human fibroblast growth factor-1 gene and on its parental cell line.." Cancer Lett.. 1995 February 10; 89 (1): 49-54. Pubmed PMID: 7533657
- Upadhyay A, Maurer J, Turner J, Tiszenkel H, Rosengart T "Elective bedside tracheostomy in the intensive care unit.." J. Am. Coll. Surg.. 1996 July ; 183 (1): 51-5. Pubmed PMID: 8673307
- Szokol JW, Murphy GS, Stagl RD, Rosengart T "Enlarged abnormal anatomic structure adjacent to the aortic valve.." J. Cardiothorac. Vasc. Anesth.. 2002 February ; 16 (1): 125-6. Pubmed PMID: 11854892
- Rosengart TK, Rotterdam H, Ranson JH "Eosinophilic cholangitis: a self-limited cause of extrahepatic biliary obstruction.." Am. J. Gastroenterol.. 1990 May ; 85 (5): 582-5. Pubmed PMID: 2337061
- Helm RE, Gold JP, Rosengart TK, Zelano JA, Isom OW, Krieger KH "Erythropoietin in cardiac surgery.." J Card Surg. 1993 September ; 8 (5): 579-606. Pubmed PMID: 8219540
- Lee LY, Zhou X, Polce DR, El-Sawy T, Patel SR, Thakker GD, Narumi K, Crystal RG, Rosengart TK "Exogenous control of cardiac gene therapy: evidence of regulated myocardial transgene expression after adenovirus and adeno-associated virus transfer of expression cassettes containing corticosteroid response element promoters.." J. Thorac. Cardiovasc. Surg.. 1999 July ; 118 (1): 26-4, discussio. Pubmed PMID: 10384181
- Lee LY, Patel SR, Hackett NR, Mack CA, Polce DR, El-Sawy T, Hachamovitch R, Zanzonico P, Sanborn TA, Parikh M, Isom OW, Crystal RG, Rosengart TK "Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121.." Ann. Thorac. Surg.. 2000 January ; 69 (1): 14-23; discussi. Pubmed PMID: 10654479
- Rosengart TK, Hillebrand K "Gene therapy for coronary artery disease.." Adv Card Surg. 2001 13 : 107-20. Pubmed PMID: 11209652
- Nayak L, Rosengart TK "Gene therapy for heart failure.." Semin. Thorac. Cardiovasc. Surg.. 2005 17 (4): 343-7. Pubmed PMID: 16428042
- Leotta E, Patejunas G, Murphy G, Szokol J, McGregor L, Carbray J, Hamawy A, Winchester D, Hackett N, Crystal R, Rosengart T "Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of congestive heart failure.." J. Thorac. Cardiovasc. Surg.. 2002 June ; 123 (6): 1101-13. Pubmed PMID: 12063456
- Rosengart TK, Johnson WV, Friesel R, Clark R, Maciag T "Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro.." Biochem. Biophys. Res. Commun.. 1988 April 15; 152 (1): 432-40. Pubmed PMID: 2451918
- Rosengart TK, Kupferschmid JP, Ferrans VJ, Casscells W, Maciag T, Clark RE "Heparin-binding growth factor-I (endothelial cell growth factor) binds to endothelium in vivo.." J. Vasc. Surg.. 1988 February ; 7 (2): 311-7. Pubmed PMID: 2448501
- Munver R, Schulman IC, Wolf DJ, Rosengart TK "Heparin-induced thrombocytopenia and thrombosis: presentation after cardiopulmonary bypass.." Ann. Thorac. Surg.. 1994 December ; 58 (6): 1764-6. Pubmed PMID: 7979757
- McCaffrey TA, Fu C, Du B, Eksinar S, Kent KC, Bush H, Kreiger K, Rosengart T, Cybulsky MI, Silverman ES, Collins T "High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis.." J. Clin. Invest.. 2000 March ; 105 (5): 653-62. Pubmed PMID: 10712437
- Schalch P, Patejunas G, Retuerto M, Sarateanu S, Milbrandt J, Thakker G, Kim D, Carbray J, Crystal RG, Rosengart TK "Homozygous deletion of early growth response 1 gene and critical limb ischemia after vascular ligation in mice: evidence for a central role in vascular homeostasis.." J. Thorac. Cardiovasc. Surg.. 2004 October ; 128 (4): 595-601. Pubmed PMID: 15457161
- Fang WC, Helm RE, Krieger KH, Rosengart TK, DuBois WJ, Sason C, Lesser ML, Isom OW, Gold JP "Impact of minimum hematocrit during cardiopulmonary bypass on mortality in patients undergoing coronary artery surgery.." Circulation. 1997 November 4; 96 (9): II-194-9. Pubmed PMID: 9386097
- Murphy GS, Szokol JW, Marymont JH, Avram MJ, Vender JS, Rosengart TK "Impact of shorter-acting neuromuscular blocking agents on fast-track recovery of the cardiac surgical patient.." Anesthesiology. 2002 March ; 96 (3): 600-6. Pubmed PMID: 11873034
- Helm RE, Klemperer JD, Rosengart TK, Gold JP, Peterson P, DeBois W, Altorki NK, Lang S, Thomas S, Isom OW, Krieger KH "Intraoperative autologous blood donation preserves red cell mass but does not decrease postoperative bleeding.." Ann. Thorac. Surg.. 1996 November ; 62 (5): 1431-41. Pubmed PMID: 8893580
- Rosengart TK "Introduction: the era of cardiac biointerventions.." Semin. Thorac. Cardiovasc. Surg.. 2003 July ; 15 (3): 217-21. Pubmed PMID: 12973699
- Rosengart TK "Invited commentary.." Ann. Thorac. Surg.. 2008 January ; 85 (1): 64. Pubmed PMID: 18154781
- Boyd WC, Rosengart TK, Hartman GS "Isolated left ventricular diverticulum in an adult.." J. Cardiothorac. Vasc. Anesth.. 1999 August ; 13 (4): 468-70. Pubmed PMID: 10468265
- Rosengart TK, Martini N, Ghosn P, Burt M "Multiple primary lung carcinomas: prognosis and treatment.." Ann. Thorac. Surg.. 1991 October ; 52 (4): 773-8; discussi. Pubmed PMID: 1929628
- Mack CA, Patel SR, Rosengart TK "Myocardial angiogenesis as a possible mechanism for TMLR efficacy.." J Clin Laser Med Surg. 1997 December ; 15 (6): 275-9. Pubmed PMID: 9641083
- Rosengart TK, Finnin EB, Kim DY, Samy SA, Tanhehco Y, Ko W, Lang SJ, Krieger KH, Isom OW "Open heart surgery in the elderly: results from a consecutive series of 100 patients aged 85 years or older.." Am. J. Med.. 2002 February 1; 112 (2): 143-7. Pubmed PMID: 11835954
- Rosengart TK, Lang S, Helm R, Friedman D "Open heart surgery in the pediatric Jehovah's Witness population: no longer Russian roulette"."." Pediatr Cardiol. 18 (3): 245-6. Pubmed PMID: 9142725
- Korst RJ, Rosengart TK "Operative strategies for resection of pulmonary sarcomas extending into the left atrium.." Ann. Thorac. Surg.. 1999 April ; 67 (4): 1165-7. Pubmed PMID: 10320276
- Rosengart TK, O'Hara M, Lang SJ, Ko W, Altorki N, Krieger KH, Isom OW "Outcome analysis of 245 CarboMedics and St. Jude valves implanted at the same institution.." Ann. Thorac. Surg.. 1998 November ; 66 (5): 1684-91. Pubmed PMID: 9875772
- Rosengart TK, Feldman T, Borger MA, Vassiliades TA, Gillinov AM, Hoercher KJ, Vahanian A, Bonow RO, O'Neill W "Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplin." Circulation. 2008 April 1; 117 (13): 1750-67. Pubmed PMID: 18332270
- Isom OW, Rosengart TK "Percutaneous aortic valvuloplasty: off the bandwagon, again.." J. Am. Coll. Cardiol.. 1992 October ; 20 (4): 804-5. Pubmed PMID: 1527291
- Sanborn TA, Hackett NR, Lee LY, El-Sawy T, Blanco I, Tarazona N, Deutsch E, Crystal R, Rosengart TK "Percutaneous endocardial transfer and expression of genes to the myocardium utilizing fluoroscopic guidance.." Catheter Cardiovasc Interv. 2001 February ; 52 (2): 260-6. Pubmed PMID: 11170342
- Rosengart TK, Kuperschmid JP, Maciag T, Clark RE "Pharmacokinetics and distribution of heparin-binding growth factor I (endothelial cell growth factor) in the rat.." Circ. Res.. 1989 February ; 64 (2): 227-34. Pubmed PMID: 2463884
- Rosengart TK, Krieger KH "Predicting transfusion.." Ann. Thorac. Surg.. 1996 December ; 62 (6): 1885-6. Pubmed PMID: 8957423
- Baumgartner WA, Burrows S, del Nido PJ, Gardner TJ, Goldberg S, Gorman RC, Letsou GV, Mascette A, Michler RE, Puskas JD, Rose EA, Rosengart TK, Sellke FW, Shumway SJ, Wilke N "Recommendations of the National Heart, Lung, and Blood Institute Working Group on Future Direction in Cardiac Surgery.." Circulation. 2005 June 7; 111 (22): 3007-13. Pubmed PMID: 15939834
- Murphy GS, Szokol JW, Marymont JH, Vender JS, Avram MJ, Rosengart TK, Alwawi EA "Recovery of neuromuscular function after cardiac surgery: pancuronium versus rocuronium.." Anesth. Analg.. 2003 May ; 96 (5): 1301-7, table o. Pubmed PMID: 12707123
- Aldrich HR, Girardi L, Bush HL, Devereux RB, Rosengart TK "Recurrent systemic embolization caused by aortic thrombi.." Ann. Thorac. Surg.. 1994 February ; 57 (2): 466-8. Pubmed PMID: 8311614
- Magovern CJ, Mack CA, Zhang J, Rosengart TK, Isom OW, Crystal RG "Regional angiogenesis induced in nonischemic tissue by an adenoviral vector expressing vascular endothelial growth factor.." Hum. Gene Ther.. 1997 January 20; 8 (2): 215-27. Pubmed PMID: 9017425
- Rosengart TK, Stark JF "Repair of atrial septal defect through a right thoracotomy.." Ann. Thorac. Surg.. 1993 May ; 55 (5): 1138-40. Pubmed PMID: 8494422
- DeBois WJ, Rosengart TK "Retrograde autologous priming reduces blood use.." Ann. Thorac. Surg.. 1998 September ; 66 (3): 987-8. Pubmed PMID: 9768986
- Rosengart TK "Risk analysis of primary versus reoperative coronary artery bypass grafting.." Ann. Thorac. Surg.. 1993 November ; 56 (5): S74-7. Pubmed PMID: 8239842
- Rosengart TK, Pass H, Cannon R, Miller DL, Solomon D, Clark RE "Ruptured gastroepiploic artery aneurysm and vascular collapse in a patient with thoracic aneurysm.." J Cardiovasc Surg (Torino). 30 (3): 514-6. Pubmed PMID: 2745544
- Kaminsky SM, Quach L, Chen S, Pierre-Destine L, Van de Graaf B, Monette S, Rosenberg JB, De BP, Sondhi D, Hackett NR, Mezey JG, Rosengart TK, Crystal RG "Safety of Direct Cardiac Administration of AdVEGF-All6A+, a Replication-Deficient Adenovirus Vector cDNA/Genomic Hybrid Expressing All Three Major Isoforms of Human Vascular Endothelial Growth Factor, to the Ischemic Myocardium of Rats.." Hum Gene Ther Clin Dev. 2013 March ; 24 (1): 38-46. Pubmed PMID: 23692382
- Harvey BG, Maroni J, O'Donoghue KA, Chu KW, Muscat JC, Pippo AL, Wright CE, Hollmann C, Wisnivesky JP, Kessler PD, Rasmussen HS, Rosengart TK, Crystal RG "Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions.." Hum. Gene Ther.. 2002 January 1; 13 (1): 15-63. Pubmed PMID: 11779412
- Mack CA, Magovern CJ, Budenbender KT, Patel SR, Schwarz EA, Zanzonico P, Ferris B, Sanborn T, Isom P, Ferris B, Sanborn T, Isom OW, Crystal RG, Rosengart TK "Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion.." J. Vasc. Surg.. 1998 April ; 27 (4): 699-709. Pubmed PMID: 9576084
- Rosengart TK, Sweet JJ, Finnin E, Wolfe P, Cashy J, Hahn E, Marymont J, Sanborn T "Stable cognition after coronary artery bypass grafting: comparisons with percutaneous intervention and normal controls.." Ann. Thorac. Surg.. 2006 August ; 82 (2): 597-607. Pubmed PMID: 16863771
- Rosengart TK, Redel DA, Stark JF "Surgical repair of aorto-right ventricular tunnel in an infant.." Ann. Thorac. Surg.. 1993 February ; 55 (2): 520-2. Pubmed PMID: 8431072
- Dang NC, Aboodi MS, Sakaguchi T, Wasserman HS, Argenziano M, Cosgrove DM, Rosengart TK, Feldman T, Block PC, Oz MC "Surgical revision after percutaneous mitral valve repair with a clip: initial multicenter experience.." Ann. Thorac. Surg.. 2005 December ; 80 (6): 2338-42. Pubmed PMID: 16305903
- Ben-Gary H, McKinney RL, Rosengart T, Lesser ML, Crystal RG "Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes.." Mol. Ther.. 2002 August ; 6 (2): 287-97. Pubmed PMID: 12349828
- Murphy GS, Szokol JW, Nitsun M, Alspach DA, Avram MJ, Vender JS, Votapka TV, Rosengart TK "The failure of retrograde autologous priming of the cardiopulmonary bypass circuit to reduce blood use after cardiac surgical procedures.." Anesth. Analg.. 2004 May ; 98 (5): 1201-7, table o. Pubmed PMID: 15105188
- Mueller RL, Rosengart TK, Isom OW "The history of surgery for ischemic heart disease.." Ann. Thorac. Surg.. 1997 March ; 63 (3): 869-78. Pubmed PMID: 9066430
- Jeremias A, Kaul S, Rosengart TK, Gruberg L, Brown DL "The impact of revascularization on mortality in patients with nonacute coronary artery disease.." Am. J. Med.. 2009 February ; 122 (2): 152-61. Pubmed PMID: 19185092
- Thakker GD, Hajjar DP, Muller WA, Rosengart TK "The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling.." J. Biol. Chem.. 1999 April 9; 274 (15): 10002-7. Pubmed PMID: 10187776
- Syed IS, Sanborn TA, Rosengart TK "Therapeutic angiogenesis: a biologic bypass.." Cardiology. 2004 101 (41277): 131-43. Pubmed PMID: 14988635
- Rosengart TK, Patel SR, Crystal RG "Therapeutic angiogenesis: protein and gene therapy delivery strategies.." J Cardiovasc Risk. 1999 February ; 6 (1): 29-40. Pubmed PMID: 10197290
- Rosengart TK, Budenbender KT, Duenas M, Mack CA, Zhang QX, Isom OW "Therapeutic angiogenesis: a comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin.." J. Vasc. Surg.. 1997 August ; 26 (2): 302-12. Pubmed PMID: 9279319
- Landesberg LJ, Ramalingam R, Lee K, Rosengart TK, Crystal RG "Upregulation of transcription factors in lung in the early phase of postpneumonectomy lung growth.." Am. J. Physiol. Lung Cell Mol. Physiol.. 2001 November ; 281 (5): L1138-49. Pubmed PMID: 11597905
- Hackett NR, El Sawy T, Lee LY, Silva I, O'Leary J, Rosengart TK, Crystal RG "Use of quantitative TaqMan real-time PCR to track the time-dependent distribution of gene transfer vectors in vivo.." Mol. Ther.. 2000 December ; 2 (6): 649-56. Pubmed PMID: 11124067
- Lee LY, O'Hara MF, Finnin EB, Hachamovitch R, Szulc M, Kligfield PD, Okin PM, Isom OW, Rosengart TK "Transmyocardial laser revascularization with excimer laser: clinical results at 1 year.." Ann. Thorac. Surg.. 2000 August ; 70 (2): 498-503. Pubmed PMID: 10969670
- Harvey BG, Hackett NR, El-Sawy T, Rosengart TK, Hirschowitz EA, Lieberman MD, Lesser ML, Crystal RG "Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs.." J. Virol.. 1999 August ; 73 (8): 6729-42. Pubmed PMID: 10400771
- Rosengart TK, Chedrawy EG, Patejunas G, Retuarto M "Vascular endothelial growth factor before cells.." J. Thorac. Cardiovasc. Surg.. 2005 March ; 129 (3): 696. Pubmed PMID: 15746767
- Zhang QX, Magovern CJ, Mack CA, Budenbender KT, Ko W, Rosengart TK "Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis.." J. Surg. Res.. 1997 February 1; 67 (2): 147-54. Pubmed PMID: 9073561
Memberships
- Alpha Omega Alpha Honor Society
- American Association for Thoracic Surgery
- Board of Directors, Education Director
- American College of Surgeons
- Fellow, Research Committee
- American Heart Association
- American Surgical Association
- Association of Academic Surgeons
- Senior Member
- Andrew Morrow Society of Cardiac Surgeons
- Seminars in Thoracic and Cardiovascular Surgery
- Editor-in-Chief (2012-2020)
- Society of Thoracic Surgeons
- Society of University Surgeons
- Society of Surgical Chairs
- President (2018-2019)
- Southern Thoracic Surgical Association
- Texas Surgical Society
Languages
Spanish
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