To date, 312 South Texas students have entered the program (137 from Baylor’s affiliated secondary schools), of whom 230 (74 percent) are Latino’s and six (two percent) are Black. Of these, 222 students already have graduated from UTRGV, 195 of who have matriculated into medical school. One hundred and forty-six PHC students have graduated from medical school (118 from Baylor College of Medicine and 28 from other Texas medical schools), and 98 have completed their residency training and now are practicing physicians (34 in South Texas communities). Twenty-four program students are currently enrolled at Baylor, and 24 undergraduate PHC students are enrolled at UTRGV.

Students receive conditional acceptance to Baylor upon acceptance into the PHC program. Those who successfully complete all PHC requirements and Baylor’s prerequisites will be accepted into Baylor's medical school upon graduation from UTRGV. As part of their undergraduate studies, PHC students have been required to major in either biology or chemistry. Students who major in biology are required to minor in chemistry, and vice versa. Entering PHC students in 2013 and beyond, also have the option of majoring in biochemistry. All students must complete the following Baylor premedical requirements by the end of their junior year: one year of English and one year of physics (including laboratory), with no grade lower than a C. Students are also required to maintain a semester and cumulative GPA average of at least 3.50 and a semester and cumulative science GPA average of at least 3.50 (on a 4.0 system). In addition, to gain admission into Baylor, PHC students must obtain a Medical College Admissions Test (MCAT) score of 500–506; with no section score (biological and biochemical foundations of living systems, chemical and physical foundations of biological systems, psychological, social and biological foundations of behavior, and critical analysis and reasoning skills) less than 125.

In 2002, the Texas Higher Education Coordinating Board awarded the Premedical Honors College its Texas Higher Education Star Award, for “closing the gaps in student participation, student success, and academic excellence in Texas.”