With collaborators throughout the United States, our mRNA vaccine technology has gained renown by using innovative mRNA vaccine formulation strategies to successfully vaccinate large mammals such as horses and elephants. Through a 15‑year collaboration between Baylor College of Medicine and the Houston Zoo, our team helped develop the world’s first elephant herpes virus (EEHV) mRNA vaccine, marking a groundbreaking advance in elephant conservation. In addition, the team contributed to the development of an mRNA-encoded monoclonal antibody for the passive immunization of horses against Rhodococcus equi. We are excited to see the translatability of the mRNA technology and are looking forward to engaging with additional collaborators interested in applying this technology.
Vaccines
- mRNA Vaccine Research
- Legere et al. — Intramuscular but not nebulized administration of a mRNA vaccine against Rhodococcus equi stimulated humoral immune responses in neonatal foals — American Journal of Veterinary Research
- Borba et al. — Maternal Immunization with VP8* mRNA Vaccine Yields Superior Passive Transfer of Rotavirus-Neutralizing Antibodies to Foals — Vaccines (Basel)
Immunotherapeutics
- mRNA-encoded monoclonal antibodies
- Legere et al. — Nebulization of a mRNA-encoded monoclonal antibody for passive immunization of foals against Rhodococcus equi — Molecular Therapy