Chagas disease (American trypanosomiasis caused by Trypanosoma cruzi), transmitted by triatomines (kissing bugs), affects by some estimates as many as 9-10 million people around the world. In total, combining years of life lost and years lived with disability, Chagas disease causes the loss of approximately 0.6 million disability-adjusted life years, a measure integrating a disease’s morbidity and mortality.
A unique product development partnership seeks to address the need for new therapeutics for Chagas disease by developing and testing vaccine candidate antigens that would eventually comprise a multivalent therapeutic vaccine. One of the components of this vaccine will likely be a unique T. cruzi 24 kDa antigen, Tc24, which is being produced at Texas Children's Hospital Center for Vaccine Development with funding from the Carlos Slim Institute for Health, SWE Medical Research Institute, and The Robert J. Kleberg Jr. and Helen C. Kleberg Foundation.
As the final product, we envision a stand-alone product to halt the progression of Chagas disease, or a complimentary therapy that will bridge the tolerability and efficacy gaps of current chemotherapy, ultimately delaying or halting the progression of chagasic cardiomyopathy.
Current activities include process development of Tc24 as well as the exploration of the feasibility of expression of other candidate antigens. We are also evaluating pre-clinical animal models for infection-induced cardiac symptoms.
Therapeutic Nanoparticle Vaccine Against Trypanosoma Cruzi in a Mouse Model of Chagas Disease
See details here about vaccine formulation; kinetics of antigen dispersal; immunogenicity; and therapeutic efficacy--view full poster
Two kissing bugs (Triatomines) collected from a deer lease near Hallettsville, Texas
Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice
Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects
Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease
A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease
Characterization and Stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a Candidate Antigen for a Therapeutic Vaccine Against Chagas Disease
Trypanosoma cruzi parasite at trypomastigote stage seen in the gut contents of a kissing bug, Triatoma sanguisuga, using dark field microscopy. This particular kissing bug was captured in Conroe, Texas.
Shown here is a kissing bug (specifically in this case Triatoma sanguisuga), the Chagas disease vector--this one was found in Conroe, Texas, and tested positive for the parasite Trypanosoma cruzi.