2014 Annual Report — Parkinson's Disease Center and Movement Disorders Clinic

Nov. 19, 2014, has been designated as National Philanthropy Day. I would like to celebrate this special day by thanking you for your generous support of our Parkinson's Disease Center and Movement Disorders Clinic. Your investment in our clinical, research and educational mission is clearly paying off as highlighted by our accomplishments below, many of which would not be possible without the continued support by you, our grateful patients and generous friends.

I want to introduce the newest member of our team, Subhashie Wijemanne, M.D. After completing her Neurology residency at Tufts University School of Medicine, where she also served as chief resident, Dr. Wijemanne completed a two-year Movement Disorders Fellowship in our program. Because of her extraordinary clinical skills, scholarly approach to neurologic problems, and her desire to continue her quest to become a clinical researcher and trialist, I invited her join our faculty. We are indeed very fortunate to have Dr. Wijemanne as a member of our team.

In addition to our primary mission to provide the most professional and compassionate patient care, we also have an active clinical research program. Leveraging Baylor's premier status in genetic research, we have intensified our research into the genetic mechanisms of Parkinson's disease, essential tremor, dystonia and other neurologic movement disorders. We are also participating in numerous investigator-initiated and multicenter collaborative studies. We are one of very few centers selected to study a novel immunotherapy with antibodies targeting α-synuclein, the toxic protein that abnormally accumulates and spreads in the brains of patients with Parkinson's disease. We are also investigating novel delivery techniques, such as inhalable levodopa. Other clinical trials in PD are designed to test new drugs that control levodopa-related dyskinesias, PD-related dementia, autonomic dysfunction, and gait abnormalities. In addition we are involved in a clinical, imaging, and genetic PD biomarker research program sponsored by The Michael J. Fox Foundation for Parkinson's Research. We are also exploring various strategies to slow or prevent the progression of the disease and to explore novel neurophysiological concepts designed to further improve outcomes of our deep brain stimulation program. In addition to PD, we are actively involved in experimental therapeutics of other diseases, such as dystonia, tremors, Huntington disease, and Tourette syndrome.

Joseph Jankovic, M.D.

Recipient of the 2014 Baylor College of Medicine Master Clinician Lifetime Award, presented by Dr. Paul Klotman, President, Baylor College of Medicine.

Presented a lecture and received the Stanley Fahn Lectureship Award at the Presidential Plenary Session, the 18th International Congress of Parkinson's Disease and Movement Disorders in Stockholm, Sweden, June 2014.

Invited to serve on the inaugural International Advisory Board of Charles University, Prague, Czech Republic, the oldest university in Central Europe.

Selected invited lectures:

- Neuroscience & Rehabilitation Conference, Bumrungrad International Hospital, Bangkok, Thailand, January 2014.
- Harvey William "Bill" Buchsbaum Visiting Lecturer, Department of Neurology, University of Arizona College of Medicine, February 2014.
- Keynote speaker at the Global Community Conference on Parkinson's Disease, Keystone, Colorado, March 2014
- Keynote speaker "Innovations in Parkinson's Disease: Past, present, and future", 40th anniversary Symposium, Houston Area Parkinsonism Society, Houston, Texas, May 2014.
- Keynote lecturer in CME courses "Meet the Professor", Rome, Italy, June 2014.
- Blepharospasm Research Foundation and University of Pittsburgh Symposium, August 2014.
- Indiana Neurological Society Annual Meeting, Indianapolis, November 2014.

Featured by the local NBC Affiliate about the documentary "The Astronaut's Secret" and about the screening of the movie with President George H.W. and Barbara Bush as honorary event chairs, April 2014 (http://www.click2houston.com/news/astronauts-space-secret-revealed-on-big-screen/25504902).

Invited article: Jankovic J, Sherer T. The future of research in Parkinson disease. JAMA Neurol 2014.

Reached an important milestone: published over 1,000 journal articles and book chapters!

Joohi Jimenez-Shahed, M.D.

Appointed Associate Neurology Residency Program Director and Chair, Clinical Competency Committee, BCM.

Panelist for the inaugural meeting of the BCM student chapter of the American Medical Women's Association, BCM.

Assumed the role of Faculty Advisor for the Student Interest Group in Neurology, encouraging students to consider Neurology as a career, BCM.

Invited lectures:
- Current Neurology 2013: "Update on Deep Brain Stimulation for Parkinson's Disease" November 2013.
- Parkinson's Advocates in Research (PAIR) Learning Institute: "Making a Difference in the Research Process"; presentation to patient advocates sponsored by the Parkinson's Disease Foundation, March 2014.
- 2014 Houston Area Parkinson Society Annual Symposium: "Innovation and Evolution of PD Therapies: a New Awakening", May 2014.
- DBS Leaders Forum, Minneapolis, October 2014.

Mary Ann Thenganatt, M.D.

Speaker at the 7th Annual Johns Hopkins Dystonia & Spasticity Practicum, Houston, November 2013.

Speaker at the Annual Texas Neurological Association meeting, Austin, Texas, February 2014.

Key Publications:
- Thenganatt MA, Jankovic J. Parkinson disease subtypes. JAMA Neurol. 2014;71:499-504.
- Thenganatt MA, Jankovic J. Treatment of dystonia. Neurotherapeutics. 2014;11:139-52.
- Thenganatt MA, Jankovic J. Psychogenic tremor: a video guide to its distinguishing features. Tremor Other Hyperkinet Mov (N Y). 2014 Aug 27;4:253.

PDCMDC, will be moving!

McNairAndMOBRevised (320x240) (320x240)
Baylor College of Medicine Medical Center, McNair Campus

Finally, I want to share with you the exciting news that the Department of Neurology, including the PDCMDC, will be moving! In January 2015 we will have a new home at the Baylor St. Luke's Medical Center, 7200 Cambridge St., 9th Floor, Houston, Texas 77030. To the right is the picture with our new building in the foreground, located on the east side of the Texas Medical Center, the world's largest medical center. I look forward to seeing you in our new state-of-the-art facility designed as an ideal setting for delivery of the most optimal patient care, the conduct of cutting edge clinical research, and a forum for training a new generation of clinical researchers.

Baylor St. Luke's Medical Center - McNair Campus

With warm appreciation,

Joseph Jankovic, M.D.