2013 Annual Report — Parkinson's Disease Center and Movement Disorders Clinic

Each year I look forward to preparing this brief report of our clinical, research and educational activities because it gives me an opportunity to highlight some of the accomplishments of the Parkinson's Disease Center and Movement Disorders Clinic at Baylor College of Medicine during the past year and to express my gratitude to my patients, friends and colleagues for their continued support. I am acutely aware that our accomplishments would not be possible without the generous support of our grateful patients and many other friends of the PDCMDC.

In addition to our primary mission to provide the most professional and compassionate patient care, we are pursuing neurological research and are currently conducting over 40 different studies, including clinical trials into cutting edge therapies in Parkinson's disease and other movement disorders such as dystonia, tremors, Huntington disease and Tourette syndrome. The PDCMDC has been selected as one of only a few centers to participate in the Parkinson's Progression Markers Initiative (PPMI), which is sponsored by The Michael J. Fox Foundation for Parkinson's Research (MJFF). This study focuses on research intended to better understand potential risk factors for Parkinson's disease and to identify PD-specific clinical, blood, cerebrospinal fluid, genetic and imaging diagnostic biomarkers.

The following is a partial list highlighting some of the accomplishments by the faculty of the PDCMDC during the 2012–13 academic year.

Accomplishment Highlights

The following is a partial list highlighting some of the accomplishments by the faculty of the PDCMDC during the 2012–13 academic year.

PDCMDC successfully completed site visits from the National Parkinson Foundation and the Huntington Disease Association of America. These visits gave us an opportunity to showcase the PDCMDC and provide an update on our activities. We have received accolades for our outstanding clinical services, research and outreach programs and have received pledges of continued support for our NPF and HDSA Centers of Excellence.

During the 17th International Congress of Parkinson's Disease and Movement Disorders, which was held in Sydney, Australia, June 16–20, Dr. Jankovic was elected by the International Parkinson and Movement Disorder Society as its 2013 Honorary Member "in recognition of his extra ordinary contribution to the field of movement disorders."

Joseph Jankovic, M.D.

During 2012–13, Dr. Jankovic published over 100 scientific articles and book chapters and seven books and volumes, including:

- Daroff RB, Fenichel GM, Jankovic J, Maziotta J, eds. Bradley's Neurology in Clinical Practice, 6th Edition, Butterworth-Heinemann (Elsevier), Philadelphia, PA, 2012:1-2162.
- Albanese A, Jankovic J, Eds. Hyperkinetic Movement Disorders. Wiley-Blackwell, Oxford, UK, 2012:1-390 (includes 75 videos accessible via QR app).
- Morris J, Jankovic J. Neurological Clinical Examination. Hodder Arnold, London, UK, 2012:1-128 (includes 110 videos accessible via QR app).
- Poewe W, Jankovic J, eds. Movement Disorders in Neurologic and Systemic Disease, Cambridge University Press, Cambridge, UK, 2013.
- Jankovic J, ed. Parkinson's Disease: Diagnosis, Motor Symptoms and Non-Motor Features. Expert Reviews E-Book Series, Future Science Group, London, UK, 2013.
- Jankovic J, ed. Parkinson's Disease: Medical and Surgical Treatment. Expert Reviews E-Book Series, Future Science Group, London, UK, 2013.

Dr. Jankovic participated in the following Continuing Medical Education programs:

- Organizing Committee, Chair and Lecturer, Toxins 2012, Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins, Miami, Fla., Dec. '12.
- Lecturer in the Dystonia Coalition's 4th Annual Meeting, Chicago, Ill., Sept. '12.
- Lecturer, The 9th Annual Update Conference on Clinical Neurology & Neurophysiology, Jerusalem, Israel, Feb. '13.
- Moderator, 2012 Controversies in Neuroscience Session, Annual American Academy of Neurology, San Diego, Calif., March '13.
- Expert Case Discussant. Unusual Movement Disorders Marathon Symposium, The Cincinnati Club, Cincinnati, Ohio, May '13.
- Key note lecturer in CME "Meet the Professor" courses in Rome and Milan, Italy, May '13.
- Co-director and lecturer of the 23rd annual CME course "A Comprehensive Review of Movement Disorders", Aspen, Colo., July '13.
- Chair and Lecturer, Physician Education: Tourette Syndrome, Sponsored by the national Tourette Syndrome Association and supported by a grant from the Centers for Disease Control (CDC), Aug '13.
- Lecturer, Neurology Update, CME course sponsored by the University of Kansas, Kansas City, Sept. '13.
- Speaker, The Michael J. Fox Foundation for Parkinson's Research – Research Roundtable, Houston, Texas, Sept. '13.
- Lecturer, Advances in Neurological Therapeutics, Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nev., Sept. '13.
- Chair of Fundraising Committee, Member of Steering Committee, Lecturer, World Parkinson Congress, Montreal, Canada, Oct. '13.
- Lecturer, annual meeting of the National Spasmodic Torticollis Association, Atlanta, Ga., Oct. '13.
- Lecturer, Managing motor symptoms and motor complications in patients with Parkinson's disease.www.peerviewpress.com.

In addition, Dr. Jankovic lectured and was a visiting professor at University of California at Irvine, University of California at San Diego, and University of Colorado at Denver. Dr. Jankovic has been interviewed by the local media, including ABC and NBC affiliates, about Parkinson's research.

Joohi Jimenez-Shahed, M.D.

Dr. Jimenez-Shahed, who directs our Deep Brain Stimulation program, has participated in the following research and academic activities:

- Completed a 2-year Master Teachers' Fellowship Program sponsored by Baylor College of Medicine.
- Elected by her colleagues in the neurology department to be their representative on the Clinical Faculty Input Committee, which reports on faculty concerns to the Academic Council of the College.
- Delivered a CME lecture to the Department of Psychiatry at The University of Texas Medical Branch on "Movement Disorders in Psychiatry."
- Invited to lecture at the 2013 Bayloe Current Neurology CME course on "Update on DBS for Parkinson's Disease."
- Discussed "Brain Boosters: What Vitamins and Supplements are Helpful in PD" at the Houston Area Parkinson Society Annual Symposium, Apr. '13.
- Presented to high school students at the National Youth Leadership Forum on Medicine on the topic of "Neurology as a Career," held at Baylor, July '13.
- Invited to present at the Davis Phinney Foundation Victory Summit – Twin Cities on the topic of "PD Research Update – Moving Onward and Upward," Sept. '13.
- Continues to partner with local area support groups on education and advocacy for patients with a variety of movement disorders.
- Our DBS program has been featured during an interview of Ashwin Viswanathan, M.D., one of our DBS neurosurgeons, on the Deborah Duncan TV show.

Mary Ann Thenganatt, M.D.

Dr. Mary Ann Thenganatt has lectured and published articles on essential tremor, dystonia, tardive dyskinesia, Tourette syndrome and spasticity.

- Lecturer, "Tardive syndromes: diagnosis and management", Current Neurology, sponsored by Baylor College of Medicine, Houston, Nov. '12.
- Lecturer, "Essential tremor: diagnosis and medical management", Learning about essential tremor, sponsored by the International Essential Tremor Foundation, Houston, March ‘13.
- Lecturer, "Pharmacotherapy of Tourette Syndrome", Physician Education: Tourette Syndrome, sponsored by the national Tourette Syndrome Association, Houston Aug. '13.

Joshua Shulman, M.D., Ph.D.

Dr. Joshua Shulman, who maintains an active clinic seeing PD patients in the PDCMDC, is principal investigator of the Laboratory for Integrative Functional Genomics and has participated in the following research and academic activities:

- Dr. Shulman's laboratory has grown to host eight affiliated scientists, including postdoctoral fellows, rotating graduate students and other personnel. Current projects are focused on the genetic mechanisms of PD, Alzheimer's disease and related neurodegenerative disorders, and use a variety of innovative approaches including both human subject genetic investigations and model organism studies.
- Dr. Shulman received a research grant from the Caroline Wiess Law Fund in Molecular Medicine at Baylor to support studies aimed at discovering novel genetic risk factors for PD through genome sequencing studies.
- Research advances were presented at numerous venues including at meetings of the American Neurological Association (Boston, Mass., Oct. '12) and the American Academy of Neurology (San Diego, Calif., Mar. '13).  Dr. Shulman was also invited to present Grand Rounds at the University of California, San Diego (Oct. '12) and to participate in the Town Gown Neurology Update at the University of Maryland (June '13).
- Dr. Shulman directs the Neuroscience Research Seminar series for neurology trainees at Baylor, and also is a member of the Faculty Operating Committee for the Medical Scientist Training Program (M.D./Ph.D.).

Notable Publications:
- Shulman, JM, et al. Genetic susceptibility for Alzheimer's disease neuritic plaque pathology. JAMA Neurology. Published online. Doi: 10.1001/jamaneurol.2013.2815.
- Buchman, AS, Nag, S, Shulman, JM, et al. Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease. Movement Disorders. 2012; 27:1625-1631.
- Cruchaga, C, Kauwe, JSK, Harari, O, Jin, SC, Shulman, JM, et al. A genome-wide association study for cerebrospinal fluid tau and phospho-tau levels identifies new candidate variants implicated in risk for Alzheimer's Disease. Neuron. 2013; 78:256-268.
- Shulman JM. Structural variation and the expanding genomic architecture of Parkinson's disease. JAMA Neurology. Published online. Doi:10.1001/jamaneurol.2013.4263.

Christine Hunter, R.N., B.S.N.

Christine Hunter, R.N., B.S.N., participated in the following activities:

- Served as a member of the Integrated Healthcare Workgroup with the goal to improve the quality of life and effectiveness of treatment for people with, or at-risk for, chronic illnesses. Symposium on Integrated Care: Exploring the Mind-Body Connection In Chronic Illness, June '13.
- Selected as the coordinator for our site participating in a Telemedicine Project in PD in collaboration with the NPF and University of Rochester.
- Served as a member of the Steering Committee with the NPF on the Aware In Care program to reach underserved populations and increase awareness related to hospitalization in PD.
- Served on the Planning Committee for the upcoming Run-to-Cure-HD which will be held at Skeeters Stadium, Sugar Land, Texas, Nov. '13.

Your Support

I hope that this partial list of our activities and accomplishments highlights the remarkable progress we are making in our search to better understand and treat neurodegenerative and movement disorders. I want to express my deep appreciation for the untiring efforts of our physicians, nurses, researchers and support staff over the past year. Their commitment to excellence has enabled the PDCMDC to remain in the forefront of patient care and research and has helped us maintain our stellar reputation as one of the premier Parkinson's and movement disorder centers in the world.

Patients and friends often ask how they can help us achieve our goals. It is increasingly clear that philanthropic support in funding innovative research and training is critical to the future success of any academic institution, including BCM. One of our primary missions at the PDCMDC is to attract and train the most promising young physicians and scientists and to prepare them for their clinical and research careers.

We need your support to continue funding the fellowship training program (annual cost about $500,000). Your investment in research and training at the PDCMDC will hasten the day when PD and other movement disorders will be effectively ameliorated or even cured. We depend upon your philanthropic partnership, which remains the foundation of our success, to achieve our important goals.

With warm appreciation,

Joseph Jankovic, M.D.