2011 Annual Report — Parkinson's Disease Center and Movement Disorders Clinic

The primary goal of this annual report is to provide a brief overview of the various activities at the Parkinson's Disease Center and Movement Disorders Clinic. Consistent with our mission, the PDCMDC has continued to be engaged in a large number of clinical, research, educational and other academic activities. Since its establishment in 1977, the physicians at the PDCMDC have evaluated over 35,000 patients with Parkinson's disease  and a variety of other movement disorders, referred not only from the southwest region of the USA, but from all over the world. Our team of researchers, including Joohi Jimenez-Shahed, M.D., assistant professor, Christine Hunter, R.N., research manager, and five movement disorder fellows, is currently conducting 45 clinical trials and other research projects approved by Baylor's Institutional Review Board for Human Research. I want to take this opportunity to express my deep appreciation for the untiring efforts of our physicians, nurses, researchers and support staff over the past year. Their commitment to excellence has enabled the PDCMDC to remain in the forefront of advances in patient care and research.

Accomplishments and Highlights

The following is a sample of our activities, transitions, and accomplishments during the past year.

The 18th floor of the Smith Tower, which houses the PDCMDC and the Department of Neurology clinic, has been completely renovated and now also features 45 fabulous photographs graciously donated by the renowned photographer and a patient with PD, Robert Flatt.

This has been an exceptionally productive year for the PDCMDC as reflected by presentations of 15 abstracts at the annual meeting of the American Academy of Neurology (AAN), Honolulu, Hawaii, April '11, and 24 abstracts at the annual Movement Disorders Congress, Toronto, Canada, June '11, more than any other movement disorder group in the world. The primary aim of the these presentations is to summarize and share some of the research findings discovered at the PDCMDC and its Parkinson's Research Laboratory at BCM on a variety of disorders such as PD, Huntington disease, Tourette syndrome, dystonia, tremors and other movement disorders.

During the past year Dr. Jankovic received several prestigious recognitions, including:

- The 2011 Dystonia Medical Research Foundation Distinguished Service Award.
- Appointment by the President of the AAN to membership on the Science Committee and as a chair of the AAN Movement Disorders Research Award Subcommittee.
- Appointment to editorial boards of the following journals: Neurotherapeutics, Tremor and Other Hyperkinetic Movements, Journal of Parkinson's Disease (these are in addition to more than a dozen of other editorial boards on which Dr. Jankovic already serves).
- In the inaugural issue of the Journal of Parkinson's Disease, Dr. Jankovic was listed among the top 20 most cited PD researchers since 1985.
- Dr. Jankovic has been selected by the National Institutes of Health to serve on a task force to develop common data elements to be used in future research on Huntington disease.
- Dr. Jankovic was elected as vice-president of the International Neurotoxin Association.

In addition to running the annual course, "Comprehensive Review of Movement Disorders for the Clinical Practitioner", in Aspen, Colo., now in its 21st consecutive year (see video), Dr. Jankovic has been directly involved in numerous other educational programs:

- Co-chair and faculty of the annual meeting of the National Parkinson Foundation Centers and Chapters Leadership Conference, Houston, Texas, Dec. '10.
- Chair and faculty of the 4th and 5th Annual Johns Hopkins Dystonia and Spasticity Practicum, Houston, Texas, Dec. '10 and Dec. '11, respectively.
- Chair and faculty of the Continuing Medical Education course, "Treatment Of Parkinsonism And Hyperkinesias (T.R.O.P.H.Y)", Houston, Texas, Jan. '11.
- Chair and faculty of "Dopamine Transporter Imaging in Neurological Practice" CME Course, sponsored by the Movement Disorders Society, Houston, Texas, Dec. '11.

Dr. Jankovic chairs the Fundraising Committee and serves on the Program Committee of World Parkinson Congress (WPC), planned for Montreal, Canada, Oct. '13.

Dr. Jankovic co-chaired the Maimonides Medical Society Dinner, Houston, Texas, April '11.

During the past year, Dr. Jankovic was an invited lecturer in the following medical schools: Wake Forest University Medical School, Bowman Gray Campus, Winston-Salem, N.C.; Beth Israel Medical Center, Albert Einstein College of Medicine, New York, N.Y.; University of Cincinnati, Ohio; Cornell University, Ithaca, N.Y.; University of Arizona; and University of Catania, Italy.

In addition to authoring over 50 peer-reviewed articles or book chapters, Dr. Jankovic was also invited to contribute an article on Tourette syndrome to a special 25th anniversary issue of the journal, Movement Disorders.

Dr. Jankovic has published the following books with 2011 or 2012 copyright:

- Fahn S, Jankovic J, Hallett M. Principles and Practice of Movement Disorders, Churchill Livingstone, Elsevier, Philadelphia, PA, 2011:1-548. (Includes online videos and references).
- Albanese A, Jankovic J, Eds. Hyperkinetic Movement Disorders. Wiley-Blackwell, Oxford, UK, 2011 (in press).
- Hallett M, Cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V. Psychogenic Movement Disorders and Other Related Conversion Disorders, Cambridge University Press, Cambridge, UK, 2011 (in press).
- Daroff RB, Fenichel GM, Jankovic J, Maziotta J, eds. Bradley's Neurology in Clinical Practice, 6th Edition, Butterworth-Heinemann (Elsevier), Philadelphia, PA, 2012 (in press).
- Morris J, Jankovic J. Neurological Clinical Examination: a concise guide. Hodder & Stoughton Limited, London, UK, 2012 (in press).

Work being done at the PDCMDC has also been featured in the media. For example, PDCMDC participation in a landmark biomarker study, referred to as PPMI, was highlighted in a KPRC-TV segment. The study is supported by the Michael J. Fox Foundation for Parkinson's Research.

Drs. Jankovic and Joohi Jimenez-Shahed were speakers at the annual educational symposium of the Houston Area Parkinson Society.

Dr. Jimenez-Shahed and Christine Hunter, R.N. continue to serve on the planning committee for the Parkinson's Disease Foundation's Clinical Research Learning Institute, a program in which participants gain knowledge and advocacy skills to encourage participation in clinical research on PD. Dr. Jimenez-Shahed presented a program at Parkinson Disease Foundation Educational Series in Florham Park, N.J. in Oct. '10. She also lectured to the Texas Association of Neurologic Surgeons on Deep Brain Stimulation in Movement Disorders in Feb. '11. She addressed the International Medical Health Organization at their 8th Annual Convention in Houston, Texas on the topic of PD in April '11.

Christine Hunter, R.N. was an invited speaker for the Movement Disorders Congress in Toronto, Canada on the Education Challenges in Newly Diagnosed persons with PD.

Christine Hunter, R.N. attended the National Huntington Disease Society of America (HDSA) Convention in Minneapolis where she co-chaired the Activity Center at the meeting with the largest attendance in history of HDSA. She also represents HDSA and the PDCMDC on a newly formed Task Force with Mental Health America to begin to promote the integration of Mental Health Services and Neurological Disorders. Christine also serves on the annual Run2CureHD Planning Committee for the 10th annual event held Oct. 15, 2011 in Sugarland, Texas

.After 16 years of service, Dr. William Ondo resigned from the PDCMDC as of Sept. 2, 2011. We thank him for his academic and research contributions as well as his patient care and wish him well in his future endeavors. We are currently actively recruiting new faculty not only to replace Dr. Ondo but also to expand and strengthen our clinical, research and educational activities.

I hope that this partial list of our activities and accomplishments serves to highlight the remarkable progress we are making in our search for better understanding and treatment of neurodegenerative and movement disorders and to train new physicians and researchers to carry on the mission of the PDCMDC. These achievements would not be possible without the support of our chair, Dr. Eli Mizrahi, to whom I express my deep gratitude. Your investment in research at the PDCMDC will hasten the day when PD and other movement disorders will be effectively ameliorated or even cured.

With warm appreciation,

Joseph Jankovic, M.D.