2010 Annual Report — Parkinson's Disease Center and Movement Disorders Clinic

Each year I try to provide a brief overview of the various activities at the Parkinson's Disease Center and Movement Disorders Clinic. Since my last annual report, the PDCMDC has been engaged in a large number of clinical, research, educational and other academic activities consistent with our missions. I want to take this opportunity to express my deep appreciation for the untiring efforts of our physicians, nurses, researchers and support staff over the past year. Their commitment to excellence has enabled the PDCMDC to remain in the forefront of advances in patient care and research. I also want to relate, on behalf of the PDCMDC, best wishes to Dr. Paul Klotman, former chair of medicine at Mount Sinai School of Medicine in New York City, who on Sept. 1, 2010 became the fifth president and chief executive officer of Baylor College of Medicine. We are optimistic that with the new leadership, Baylor will continue to maintain the highest standing among U.S. medical schools.

Accomplishments and Highlights

The following are some of the developments and accomplishments of the PDCMDC over the past year:

This summer, the Department of Neurology underwent extensive renovations of the Neurology Clinic as well as the PDCMDC in Smith Tower, Suite 1801. The feedback from patients and visitors about the new décor has been extremely positive. The renovations have also allowed the addition of neuropsychology and other new faculty and staff to have their presence on Smith 18 which will facilitate more effective services and closer interaction.

We have successfully transitioned to electronic medical records which provides for more efficient and secure sharing of patient information.

We are very pleased that, as of Aug. 1, 2010, Dr. Jimenez-Shahed has re-joined our team as assistant professor of neurology (tenure track). She is ready and eager to see new (and former) patients with Parkinson's disease, Tourette syndrome, and other movement disorders, including patients who are treated with deep brain stimulation. She is looking forward to resuming her active role in the PDCMDC. She currently serves on the Planning Committee and as faculty for the Parkinson's Disease Foundation's Clinical Research Learning Institute, a multi-day educational seminar which aims to train people with Parkinson's to educate and empower the broader community about the importance of Parkinson's clinical research (http://www.pdf.org/crli).

One of the most important and rewarding activities of the PDCMDC is the training of emerging experts in the field of movement disorders. In addition to our own fellows, the PDCMDC fellowship training program has been sought during the past year by international trainees from Australia, Italy, Mexico, Turkey, and other countries. These and other fellows from around the world also attended the 20th annual course "Comprehensive Review of Movement Disorders for the Clinical Practitioner", held in Aspen, Colorado and co-directed by Dr. Jankovic.

Since the last annual report Dr. Jankovic has received the following honors:

- Dr. Jankovic, was selected by the National Institute of Health as the "Great Teacher" and presented a special NIH Clinical Center Grand Rounds on "Treatment of Parkinson's Disease", December 2009.
- Dr. Jankovic received the 2010 Fulbright & Jaworski Faculty Excellence Award for Teaching and Evaluation and has become a member of the Academy of Distinguished Educators, which recognizes the educational scholarship of faculty members involved in all of the educational missions of the Baylor College of Medicine.
- Dr. Jankovic was recognized by the 2010 Baylor College of Medicine Alumni Association Distinguished Faculty Award and delivered a special alumni lecture on "Parkinson's Disease and Movement Disorders: Moving Forward, Breaking Boundaries."
- Dr. Jankovic was invited to serve on the Executive Scientific Advisory Board of the Michael J. Fox Foundation for Parkinson's Research.
- In addition to his membership on several editorial boards, Dr. Jankovic was invited this year to also join the editorial board of Neurotherapeutics and the new Journal of Parkinsonism and the Journal Tremor and other Hyperkinetic Movements.

In addition to lecturing at the annual meeting of the American Academy of Neurology, Dr. Jankovic has also been invited as a speaker in other national and international programs and to present the following special lectures:

- Lecturer, 43rd Annual Recent Advances in Neurology, UCSF, San Francisco. This is the third time Dr. Jankovic was selected as the guest speaker in this highly prestigious CME course, February 2010.
- The Richmond Paine Lectureship, a keynote address at the annual Pediatric Neurology Update, The Children's National Medical Center, The George Washington University, Washington, DC, March 2010.
- 33rd Annual Lewis A. Leavitt, MD Memorial Lectureship, Baylor College of Medicine and University of Texas, Houston, July 2010.
- Invited as a speaker at the European Huntington Disease Network plenary meeting in Prague and as a visiting professor at the First Department of Neurology, Masaryk University, Brno, Czech Republic, September 2010.
- An organizer and an invited speaker at the World Parkinson Congress, Glasgow, Scotland, Scotland, September 2010.
- Visiting professor at the Department of Clinical Neurosciences, Western General Hospital, Edinburgh, Scotland, September 2010.
- A key note lecturer at the "The 1st Therapy Symposium on Movement Disorders for the Modern Clinician: A 2010 Update", Cleveland Clinic, Cleveland, OH, October 2010.

Physicians and scientists at the PDCMDC published over 50 peer-reviewed articles in the past year and presented numerous abstracts at various international meetings.

- Over 20 abstracts were presented by the PDCMDC physicians and scientists at the 14th Annual Movement Disorders Society Congress in Buenos Aires, Argentina, more than any other center in the world!

Dr. Jankovic has recently published or is writing/editing the following textbooks:

- Jankovic J, Tolosa E, eds. Parkinson's Disease and Movement Disorders (and video atlas), Lippincott Williams and Wilkins, Philadelphia, PA;
- Fahn S, Jankovic J. Principles and Practice of Movement Disorders, (along with DVD of hundreds of patients with a variety of movement disorders), Churchill Livingstone, Elsevier, Philadelphia, PA;
- Daroff RB, Fenichel GM, Jankovic J, Mazziotta J, eds. Neurology in Clinical Practice, Butterworth-Heinemann (Elsevier), Philadelphia, PA;
- Jankovic J (chief editor), Albanese A, Atassi MZ, Dolly JO, Hallett M, Mayer N. Botulinum Toxin. Therapeutic Clinical Practice and Science. Saunders (Elsevier), Philadelphia, PA;
- Singer HS, Mink JW, Gilbert DL, Jankovic J. Movement Disorders in Children, Butterworth-Heinemann (Elsevier), Philadelphia, PA;
- Jankovic J, Editor. Movement Disorders. Neurologic Clinics, W. B. Saunders, Elsevier, Philadelphia, PA;
- Albanese A, Jankovic J, Eds. Hyperkinetic Movement Disorders. Wiley-Blackwell, Oxford, UK; and 
- Black K, Jankovic J, eds. Tourette syndrome: 125th Anniversary. Mov Disord Supplement.

Dr. Jankovic is currently the principal investigator on dozens of clinical studies, including the Parkinson's Progression Markers Initiative, funded by the Michael J. Fox Foundation for Parkinson's Research, and a new CERE-120 trial which investigates the role of gene delivery of the trophic factor neurturin via adeno-associated type-2 vector in the striatum and substantia nigra of moderately advanced Parkinson's patients.

This year, Dr. Ondo, associate director of the PDCMDC, lectured at the American Academy of Neurology, The World Parkinson Congress, and the Association of Sleep Professionals World Congress, as well as numerous Grand Rounds and other formal lectures. He wrote and edited the book "Movement Disorders in Clinical Practice" along with Ray Chaudhuri, and numerous medical articles in peer reviewed journals, while maintaining a busy clinical practice in the Department of Neurology.

I am also very proud of our research manager, Christine Hunter, R.N., who also serves as a member of the planning committee of the PDFCRLI. Christine has been recently elected to the executive committee of the Huntington Study Group and has been recognized by the national Huntington Disease Association of America and by the Tourette Syndrome Association of Texas for her inspiring leadership in research and patient services.

In addition to the clinical research activities, our Parkinson Disease Research Laboratory, co-directed by Wei-Dong Le, M.D., Ph.D., and supported by grants from NIH, The Michael J. Fox Foundation for Parkinson's Research, The Diana Helis Henry Medical Research Foundation, and other sources, has made remarkable advances in the understanding of mechanisms of neurodegeneration. Through these research efforts we may be able to identify disease pathways and develop novel neuroprotective drugs.

I hope that this partial list of our accomplishments and accolades serves to highlight the remarkable progress we are making in our search for better understanding and treatment of neurodegenerative and movement disorders. These achievements would not be possible without the support and leadership of our chair, Dr. Eli M. Mizrahi, to whom I express my deep gratitude. Your investment in research at the PDCMDC will hasten the day when Parkinson's disease and other movement disorders will be effectively ameliorated or even cured.

With warm appreciation,

Joseph Jankovic, M.D.