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research › faculty-labs › richard-lloyd-lab
… infection triggers of integrated stress responses and Type 1 Diabetes. Enteroviruses such as poliovirus and … play prominent roles in the integrated stress response. We found that enterovirus 3Cpro cleaves a protein G3BP1 that is … now emerging as platforms that activate innate immunity. We found that G3BP1 nucleation of stress granules activates …
departments › ... › left-ventricular-non-compaction
… Left ventricular noncompaction is characterized by deep trabeculations in the LV … myocardium is a rare congenital cardiomyopathy of children and adults resulting from arrested myocardial development … the latter case, this non-isolated LV noncompaction may be found in combination with septal defects, pulmonic stenosis …
research › ... › fatigue
… The most common and troublesome secondary condition reported by women with … participating in one study. … Fatigue can have a profound impact on the physical, psychological, and social … is such a common, debilitating secondary condition, there remains a dearth of literature on the causes, …
news › an-organic-insecticide-is-more-damaging-to-non-target-insects-than-synthetics
… Very low concentrations of the popular organic insecticide Spinosad have profound effects on beneficial insect species, including vision … impacts on the brain and other tissues. Spinosad is commonly used to control insect pests, including thrips, …
research › faculty-labs › matthew-rasband-lab
… Dr. Rasband's team is discovering the functional organization of … ion channel/receptor clustering in the nervous system are found at the synapse, the node of Ranvier, and the axon … the identification and characterization of synaptic protein components and complexes has led to remarkable advances in …
news › genomic-assessment-of-cancer-predisposition-landscape-of-pediatric-rhabdomyosarcoma
… Rhabdomyosarcoma (RMS) is a highly malignant tumor and the most common soft tissue sarcoma in … patient age. In tumor subtype analysis, the team found that patients with embryonal RMS were significantly …
news › microbes-may-hold-the-key-for-treating-neurological-disorders
… When we think about the causes of neurological disorders and how to treat them, we think about targeting the brain. … the gut may contribute to certain symptoms associated with complex neurological disorders. The findings, published in … treat them. Dr. Mauro Costa-Mattioli , professor and Cullen Foundation Endowed Chair in neuroscienc e and director of …
news › circadian-clock-in-heart-failure
… Disrupting circadian rhythms, which change naturally on a 24-hour cycle, has … investigated the function of the protein Rev-erbα/β, a key component of the circadian clock, on heart disease … and lipids, during both the awake and sleep hours. They found that the Rev-erbα/β gene is highly expressed only …
research › ... › projects
… Genetically engineered mouse models (GEMMs). Retroviral transformation and transplantation of mouse hematopoietic stem cells using oncogenes found in leukemia patients Patient-derived xenografts (PDXs) … kinase inhibitors (TKIs) have dramatically improved outcomes for CML patients, yet they fall short of a cure. Most …
departments › ... › influenza-virus-flu
… been seen before - suddenly appeared. The novel virus, commonly called swine flu, is named influenza A (H1N1). … birds, pigs, and horses. Type B influenza is normally found only in humans, and type C is mostly found in humans, … 60 million Americans became infected with the H1N1 virus, 265,000 Americans were hospitalized and 12,000 deaths …
