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news › molecular-profile-predicts-tumor-recurrence
… Although typically benign, about one-fifth of meningiomas, the most common … the other hand, a portion of grade I tumors, which are generally cured with surgery, recur despite complete resection … been redefined based on molecular and genetic features, allowing for improved prognostication and potential …
news › tgf-beta-protects-against-uterine-cancer
… , director of the Center for Drug Discovery , Stuart A. Wallace Chair, Robert L. Moody, Sr. Chair and professor of … at Princeton University and their colleagues genetically modified mice to lack ALK5, which mediates TGF-beta … and her colleagues. In this case, the researchers genetically modified mice to lack two other proteins, Smad2 and …
research › ... › drosophila-genetics
… a high-throughput and in vivo genetic validation strategy, allowing us to comprehensively evaluate promising loci from … RNA-interference (RNAi) lines are available for nearly all fly genes, as well as putative overexpression lines for … aggregation and neurotoxicity in vivo. We will initially focus on genes identified by PD GWAS consortia and …
healthcare › specialties › allergy-and-immunology
… a unique, comprehensive treatment option for patients with Allergic and Immunologic conditions in a single location. We diagnose and manage the following Allergic and Immunologic conditions and provide the … examination, perform and analyze the results from the allergy skin testing and other laboratory tests to determine …
news › impact-newborn-genomic-screening
… becomes increasingly popular and accessible, an effort called the BabySeq Project aims to explore the medical, … to gauge how parents respond to this information psychologically and behaviorally, and how useful physicians perceive it to be. “Other …
research › ... › current-lab-members
… helped Dr. Timothy Palzkill build the lab. She has helped all of the trainees and other scientists who have gone through the lab. After 27 years of service, she officially retired during September of 2020 but will always be a … postdoctoral researcher, specializing in the synthesis of small molecules for Zika virus and PROTAC molecules targeting …
research › faculty-labs › david-bates-lab
… is encoded in a one-dimensional array of DNA bases, all major DNA processes (replication, transcription, and … sites (origins, termini, and centromeres) and overall chromosome compactness change dramatically and predictably during the cell cycle. One major … changing the cellular abundance of a type II topoisomerase called Topo IV, a homolog of Human TopoII ( Joshi et al, 2013 …
news › dna-fracturing-rewires-gene-control-in-cancer
… altered DNA methylation affecting hundreds of genes, overall reducing the global level of DNA methylation across … it’s part of the epigenome. The epigenome refers to all the chemical modifications to DNA and associated … involved in the disease, others might be ‘passengers.’” Overall, structural variation was associated with a global …
news › bacteria-help-discover-cancer-causing-protein
… The researchers genetically modified bacteria so they would fluoresce red when DNA … each of the 4,000 genes present in E coli individually and determined which ones made bacteria glow red. “We … the University of Texas at Austin. See a complete list of all the contributors and their affiliations and the …
news › how-keep-germs-out-classrooms
… hands as frequently or as thoroughly as adults do – especially the younger ones,” Valdez said. “Preschool-age children … teenagers tend to put pens or pencils in their mouths and all of those things can harbor germs, especially if they shared them with someone who is ill. It’s very …
