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… Regulation of Hematopoietic Stem Cells and Development of Hematologic Malignancies … the hematopoietic (blood-forming) stem cell (HSC) that resides in the bone marrow. Despite decades of work, little is known about the factors or mechanisms that regulate them. We are using HSCs as a paradigm to understand the …
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… “All work and no play makes Jack a dull boy All work and no play makes Jack a dull boy All work and no play makes Jack a … creativity. And remember to take pictures. Activities include lab lunches to celebrate accepted papers, funded grants, … Tom Cooper Lab Activities …
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… The William's lab isn't currently recruiting for positions at this time. … We have opportunities for graduate students to join the lab and participate in our research. … Graduate Students … Williams Lab Job Openings …
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… axis, but how is this coordination achieved at the molecular level? We are working to identify ‘molecular translators’ that allow complex spatial cues to be interpreted by an embryo’s … Such asymmetry is apparent within zebrafish embryo explants, which recapitulate axial extension in culture, but …
research › ... › publications
… Alaniz Emig A, Williams MLK. Generation of Naïve Blastoderm Explants from Zebrafish Embryos. J Vis Exp. 2021 … Yin, Paul Gontarz, and Lilianna Solnica-Krezel. Gon4l regulates notochord boundary formation and cell polarity … axis extension by repressing adhesion genes. Nature Communications . 2018 April 3; 9(1):1319. View article …
research › ... › publications
… Chem. 2012 Feb 3;287(6):4014-22. doi: 10.1074/jbc.M111.312264. Epub 2011 Nov 10. PMID:22074915 Hou S, Horrigan FT, Xu … doi: 10.1074/jbc.M109.027789. Epub 2009 Jun 26. PMID:19561088 Horrigan FT, Hoshi T. Integration of an … activation of the Slo1 BK channel. J Gen Physiol. 2005 Jul;126(1):7-21. Epub 2005 Jun 13. PMID:15955873 Zhang G, …
research › ... › lab-members
… Postdoctoral Fellow (2016-2023) Current position: Senior Scientist, Nitto … Graduate Student (2014-2020) Postdoctoral Fellow (2021-2023) Current position: Postdoctoral Fellow, Baylor College of Medicine … Graduate Student (2016-2019) Postdoctoral Fellow (2020) Current …
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… contributor to human disease. The overarching goal of our lab is to explain how variants in the human genome may lead to disease. We develop robust statistical models -- combining biophysics, machine learning, and comparative … and other DNA binding proteins are the most direct regulators of gene expression. It is generally assumed that …
research › ... › research-areas
… Our laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases, the function of Math1 in neurodevelopment, and how MECP2 mutations cause postnatal … we found that mutant Ataxin-1 has to be in its native complexes (that contain Capicua) to make its pathogenic …