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news › study-reveals-epigenetic-vulnerability-of-acute-myeloid-leukemia
… Acute myeloid leukemia (AML) is an aggressive blood cancer that … accumulation of white blood cells. Because of the poor outcomes of this disease, researchers across the globe have … a class of experimental drugs. These drugs target a protein complex called SWI/SNF, which many cells use to make DNA …
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… the newborn period, skeletal muscle growth is significantly compromised. Nutritional rehabilitation after weaning does … for long-term cardiovascular dysfunction. We found that, compared to males, young adult females that had been … disproportionately smaller and dysfunctional hearts with compromised maximal exercise capacity. With progressive …
research › ... › publications
… Putluri, N., Perini, G., Coarfa, C., & Barbieri, E. 2022. MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma . Nat Commun , 13(1): 3728. Kellman, B. P., Richelle, A., Yang, J. … genes through network-based multi-omics integration . Nat Commun , 13(1): 2455. Mohammad, M. A ., Didelija, I. C., …
news › ai-used-to-reduce-intrapartum-stillbirths-and-early-neonatal-deaths-in-malawi
… professionals in the United States to promote safe outcomes for mothers and babies. The deployment of this … promising results for future opportunities in low-income settings. Fetal monitoring is standard in high-income settings but very limited in low-income countries like …
news › heart-disease-remains-the-leading-cause-of-death-worldwide
… believe these numbers will be impacted by COVID-19 in the coming years. Virani chairs the committee made up of expert volunteers working on behalf of … Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. He also is …
news › circadian-clock-gene-rev-erb-linked-to-dawn-phenomenon-in-type-2-diabetes
… at Rev-erb gene expression in patients with type 2 diabetes comparing a group with dawn phenomenon to a group without it … “We are interested in this gene because it is a ‘druggable’ component of the circadian clock with potential applications … area called the suprachiasmatic nucleus that is mainly composed of GABA neurons. An unexpected finding “We observed …
news › mouse-model-closely-reproduces-human-fatty-liver-disease
… University. The disease has both genetic and nutritional components, which have been hard to understand in human … expertise developing chimeric mouse models, those that combine both human and murine cells, we developed mice with … All the analyses pointed at cholesterol metabolism being changed in this model in a way that closely replicates what …
news › unraveling-the-complexity-of-vitamin-b12-diseases
… and collaborating institutions has shed new light into the complexity of vitamin B12 diseases. The scientists studied … the same gene but are clinically distinct from the most common genetic vitamin B12 disorder. This work suggested … David Watkins, Joel R. Neilson, Perumal Thiagarajan, Jeremy B. A. Green, Anna Malovannaya and James F. Martin. The …
news › model-of-the-human-nose-shows-sars-cov-2-and-rsv-infection
… infection take place. Using nose organoids, which model the complex interactions between human cells and virus, the team … of Texas (CPRIT; RP150578, RP170719), the Dan L. Duncan Comprehensive Cancer Center and the John S. Dunn Gulf Coast …
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… with Heart Failure Javad Razjouyan Physical frailty is common in adults with heart failure and increases the risk for poor health outcomes. Clinicians need tools to identify adults with … will develop and test a new and unique intervention that combines evidence-based care transitions training with …
