About the Core
The Gene Vector Core was founded in 1997 as the Adenovirus Vector Production Core. Over the years, we have extended our expertise to other popular viral vector systems. Our core has been one of BCM Advanced Technology Cores since October 2013. More recently, the Vector Development Laboratory merged with our group, and we have expanded our services to offer AAV, first-generation adenovirus (FGAd), helper-dependent adenovirus (HDAd), Lentivirus (LV), Retrovirus (RV), and G-deleted Rabies (RaV). In addition, we have a variety of supporting services available such as subcloning, plasmid preparation, viral titration, and other Quality Controls assays.
Our services are available to all national and international institutions (non-profit and profit).
Vectors Production
There is no single viral vector system fit for all purposes. Professional consultation is provided by a group of experienced staff, dedicated to the production of viral vectors for use in basic research. We can prepare viral vectors to Good Laboratory Practice standards. The preclinical data generated by agents produced by the GLP practice can be valuable in the later development of clinical trials in gene therapy.
To help investigators choose the optimum vector system for their proposed application, the Core has many in-stock vectors containing a range of reporters, which will provide essential information about transduction.
All our viral vectors are produced and purified following Standard Operating Procedures. Infectious titers and other quality control assays may be subject to an additional charge. The core has various expression cassettes and basic transfer vectors for expressing your genes including shRNA and gRNA. Many plasmids developed in the Core have been deposited to Addgene. There is no additional charge for standard packaging plasmids and helper viruses.